Investigating antimalarial drug interactions of emetine dihydrochloride hydrate using CalcuSyn-based interactivity calculations. [PDF]
PLoS ONE, 2017 The widespread introduction of artemisinin-based combination therapy has contributed to recent reductions in malaria mortality. Combination therapies have a range of advantages, including synergism, toxicity reduction, and delaying the onset of ...
Holly Matthews +4 more
doaj +8 more sources
Complete attenuation of Plasmodium falciparum sporozoites by atovaquone–proguanil [PDF]
EMBO Molecular MedicineTo develop a Plasmodium falciparum (Pf) vaccine that precludes replication inside the host for improved vaccine safety, we tested chemo-attenuation (CVac) of sporozoites (SPZ) with atovaquone–proguanil (AP). In mice, P.
Steffen Borrmann +39 more
doaj +2 more sources
Atovaquone-proguanil and reduced digestive cancer risk: a Toxoplasma gondii connection [PDF]
Gut MicrobesEmerging evidence suggests microbial pathogens contribute to digestive cancer risk. Atovaquone – proguanil (A-P), an antimalarial with antiparasitic activity, has been associated with a reduced risk of colorectal cancer (CRC).
Ariel Israel +6 more
doaj +2 more sources
Atovaquone/proguanil-induced autoimmune-like hepatitis. [PDF]
Hepatol Commun, 2017 We report a novel association between the commonly used antimalarial medication atovaquone/proguanil and drug‐induced autoimmune‐like hepatitis. The patient developed severe liver disease fulfilling biochemical, immunologic, and histologic criteria for the diagnosis of autoimmune hepatitis after the inadvertent rechallenge with the offending drug ...
Terziroli Beretta-Piccoli B +6 more
europepmc +3 more sources
Splenic accumulation of intact Plasmodium ovale sensu lato-infected red blood cells in a patient presenting with splenic rupture. [PDF]
PLoS Neglected Tropical DiseasesA 35-year-old man had splenic rupture just after starting antimalarial treatment with atovaquone-proguanil followed by artesunate for acute Plasmodium ovale sensu lato infection. Spleen histology showed a 10-fold accumulation of intact P.
Ghania Benabdelmoumen +11 more
doaj +2 more sources
Congenital babesiosis in China: first molecularly confirmed case of vertical transmission of Babesia microti [PDF]
Emerging Microbes and InfectionsCongenital babesiosis is rarely reported globally. We report a 74-day-old male infant presented with fever, pallor, and severe, life-threatening haemolytic anaemia (haemoglobin: 45 g/L).
Junwen Liu +10 more
doaj +2 more sources
Treatment of avian malaria in captive African penguins (Spheniscus demersus) by the combination of atovaquone and proguanil hydrochloride [PDF]
International Journal of Veterinary Science and MedicineAvian malaria, a vector-borne disease caused by Plasmodium spp., poses significant threats to various bird populations, particularly captive penguins like the endangered African penguin (Spheniscus demersus).
Rossella Samarelli +9 more
doaj +2 more sources
Evaluation of in vitro drug-drug interactions of ivermectin and antimalarial compounds [PDF]
Malaria JournalBackground Ivermectin is lethal to Anopheles mosquitoes and a novel approach to malaria transmission control. Ivermectin could be co-administered with antimalarial drugs in mass drug administration, seasonal malaria chemoprevention, or other ...
Phornpimon Tipthara +3 more
doaj +2 more sources
Acute malaria infection after atovaquone-proguanil prophylaxis. [PDF]
J Travel Med, 2017 Minta AA, Tan KR, Mace KE, Arguin PM.
europepmc +4 more sources
BMC Medicine, 2022 Background Individuals with a family history of colorectal cancer (CRC) are at a high risk of developing CRC. Preclinical studies suggest that the anti-malaria drug proguanil and atovaquone might play a role in preventing CRC, but population-based ...
Naiqi Zhang +3 more
doaj +1 more source