Results 11 to 20 of about 3,667 (197)
Absence of an interaction between artesunate and atovaquone - proguanil
European Journal of Clinical Pharmacology, 1999 Atovaquone plus proguanil is a new, well-tolerated and highly effective antimalarial drug. In order to protect it from the development of resistance, it may be deployed in combination with an artemisinin derivative. To investigate whether artesunate affects the pharmacokinetics of atovaquone plus proguanil, and to provide preliminary information ...
M Van Vugt +2 more
exaly +4 more sources
Malarone treatment failure and
Malaria Journal, 2002 We report the first in vitro and genetic confirmation of Malarone® (GlaxoSmithKline; atovaquone and proguanil hydrochloride) resistance in Plasmodium falciparum acquired in Africa.
Warhurst David C +4 more
doaj +3 more sources
BMC Medicine, 2022 Background Individuals with a family history of colorectal cancer (CRC) are at a high risk of developing CRC. Preclinical studies suggest that the anti-malaria drug proguanil and atovaquone might play a role in preventing CRC, but population-based ...
Naiqi Zhang +3 more
doaj +2 more sources
Marked increase in etravirine and saquinavir plasma concentrations during atovaquone/proguanil prophylaxis [PDF]
Malaria Journal, 2011 The case of a 32-year-old Caucasian female with multi-drug resistant HIV-1 subtype B infection treated with a salvage regimen including maraviroc, raltegravir, etravirine and unboosted saquinavir who started atovaquone/proguanil prophylaxis, is reported.
Ivanovic Jelena +8 more
doaj +2 more sources
Brazilian Journal of Infectious DiseasesThe efficacy and safety of a fixed-dose combination of atovaquone and proguanil hydrochloride (MalaroneTM) were compared with chloroquine or pyrimethamine/sulfadoxine in patients with acute falciparum malaria in northern Peru.
A. Llanos-Cuentas +4 more
doaj +2 more sources
Atovaquone-proguanil for treating uncomplicated Plasmodium falciparum malaria. [PDF]
Cochrane Database Syst Rev, 2021 BackgroundThe World Health Organization (WHO) in 2015 stated atovaquone‐proguanil can be used in travellers, and is an option in malaria‐endemic areas in combination with artesunate, as an alternative treatment where first‐line artemisinin‐based ...
Blanshard A, Hine P.
europepmc +2 more sources
Plasmodium falciparum Malaria and Atovaquone-Proguanil Treatment Failure
Emerging Infectious Diseases, 2008 We noticed overrepresentation of atovaquone-proguanil therapeutic failures among Plasmodium falciparum–infected travelers weighing >100 kg. We report here 1 of these cases, which was not due to resistant parasites or impaired drug bioavailability.
Rémy Durand +7 more
doaj +2 more sources
Treatment of avian malaria in captive African penguins (Spheniscus demersus) by the combination of atovaquone and proguanil hydrochloride [PDF]
International Journal of Veterinary Science and MedicineAvian malaria, a vector-borne disease caused by Plasmodium spp., poses significant threats to various bird populations, particularly captive penguins like the endangered African penguin (Spheniscus demersus).
Rossella Samarelli +9 more
doaj +2 more sources
Drugs, 2003 Atovaquone/proguanil is a fixed-dose combination tablet of two antimalarial agents and is highly effective for the prevention of Plasmodium falciparum malaria. In combination with proguanil, the ability of atovaquone to inhibit parasitic mitochondrial electron transport is markedly enhanced. Both atovaquone and proguanil are active against hepatic (pre-
McKeage, K, Scott, L
openaire +3 more sources
Brazilian Journal of Infectious Diseases, 2001 The efficacy and safety of a fixed-dose combination of atovaquone and proguanil hydrochloride (MalaroneTM) were compared with chloroquine or pyrimethamine/sulfadoxine in patients with acute falciparum malaria in northern Peru.
Llanos-Cuentas A. +4 more
doaj +1 more source