Results 31 to 40 of about 3,499 (203)

Severity of imported malaria: protective effect of taking malaria chemoprophylaxis [PDF]

, 2013
BACKGROUND: Although chemoprophylaxis remains an important strategy for preventing malaria in travellers, its effectiveness may be compromised by lack of adherence. Inappropriate use of chemoprophylaxis is likely to increase the risk of acquiring malaria,
Jaap J van Hellemond, Klaske Vliegenthart-Jongbloed, Mariana de Mendonça Melo, Marlies E van Wolfswinkel, Perry JJ van Genderen, Rob Koelewijn   +5 more
core   +2 more sources

Detection of atovaquone-proguanil resistance conferring mutations in Plasmodium falciparum cytochrome b gene in Luanda, Angola

Malaria Journal, 2006
Background The fixed dose combination atovaquone-proguanil is a recently introduced antimalarial for treatment and prophylaxis of Plasmodium falciparum malaria. It is highly effective with a good tolerability profile and a convenient prophylactic regimen.
Varandas Luís, Bom Joana, Quinhentos Vatúsia, Benchimol Carla, Nogueira Fátima, Pimentel Sónia, do Rosário Virgílio, Bernardino Luís   +7 more
doaj   +1 more source

Lead optimisation of dehydroemetine for repositioned use in malaria [PDF]

, 2020
Drug repositioning offers an effective alternative to de novo drug design to tackle the urgent need for novel anti-malarial treatments. The anti-amoebic compound, emetine dihydrochloride, has been identified as a potent in-vitro inhibitor of the multi ...
Abubaker, M, Bryce, RA, Burusco, KK, Fernández-Álvaro, E, Gutnov, A, Matthews, H, Nirmalan, NJ, Panwar, P, Wilkinson, JA   +8 more
core   +3 more sources

Different mutation patterns of atovaquone resistance to Plasmodium falciparum in vitro and in vivo: rapid detection of codon 268 polymorphisms in the cytochrome b as potential in vivo resistance marker

Malaria Journal, 2003
Background Resistance of Plasmodium falciparum to atovaquone in vitro and in vivo has been associated to mutations in the parasite cytochrome b gene. Methods Cultures were sequentially subjected to increasing doses of atovaquone alone or in combination ...
Salanti Ali, Alifrangis Michael, Schwöbel Babett, Jelinek Tomas   +3 more
doaj   +1 more source

In vivo assessment of drug efficacy against Plasmodium falciparum malaria: duration of follow-up. [PDF]

, 2004
To determine the optimum duration of follow-up for the assessment of drug efficacy against Plasmodium falciparum malaria, 96 trial arms from randomized controlled trials (RCTs) with follow-up of 28 days or longer that were conducted between 1990 and 2003
Stepniewska, K, Taylor, W R J, Mayxay, M, Price, R, Smithuis, F, Guthmann, J P, Barnes, K, Myint, H Y, Adjuik, M, Olliaro, P, Pukrittayakamee, S, Looareesuwan, S, Hien, T T, Farrar, J, Nosten, F, Day, N P J, White, N J   +16 more
core   +2 more sources

Plasmodium falciparum Malaria and Atovaquone-Proguanil Treatment Failure

Emerging Infectious Diseases, 2008
We noticed overrepresentation of atovaquone-proguanil therapeutic failures among Plasmodium falciparum–infected travelers weighing >100 kg. We report here 1 of these cases, which was not due to resistant parasites or impaired drug bioavailability.
Rémy Durand, Virginie Prendki, Johann Cailhol, Véronique Hubert, Pascal Ralaimazava, Laurent Massias, Olivier Bouchaud, Jacques Le Bras   +7 more
doaj   +1 more source

A randomized feasibility trial comparing four antimalarial drug regimens to induce Plasmodium falciparum gametocytemia in the controlled human malaria infection model. [PDF]

, 2018
BACKGROUND: Malaria elimination strategies require a thorough understanding of parasite transmission from human to mosquito. A clinical model to induce gametocytes to understand their dynamics and evaluate transmission-blocking interventions (TBI) is ...
Adjalley, Bolscher, Bousema, Bousema, Bousema, Bousema, Butcher, Cheng, Ciuca, Delves, Duffier, Eichner, Farid, Gonçalves, Graumans, Griffin, Griffin, Hermsen, Kafsack, Lasonder, Laurens, Lensen, Moonen, Méndez, Nilsson, Ouédraogo, Pasay, Pett, Ponnudurai, Ponnudurai, Reuling, Sauerwein, Schneider, Shute, Sinden, Staedke, Stone, Stone, Stone, Stone, Team SD, Wells, White, White, Witkowski, World Health Organization, World Health Organization, WWARN Gametocyte Study Group   +47 more
core   +10 more sources

Ototoxicity of artemether/lumefantrine in the treatment of falciparum malaria: a randomized trial

Malaria Journal, 2008
Background Due to increasing drug resistance, artemisinin-based combination chemotherapy (ACT) has become the first-line treatment of falciparum malaria in many endemic countries. However, irreversible ototoxicity associated with artemether/lumefantrine (
Krause Eike, Girma Tsinuel, Mamo Yoseph, Berens-Riha Nicole, Miranda Isabel, Eshetu Teferi, Gürkov Robert, Schmidt Michael, Hempel John-Martin, Löscher Thomas   +9 more
doaj   +1 more source

Atovaquone and proguanil hydrochloride compared with chloroquine or pyrimethamine/sulfadoxine for treatment of acute Plasmodium falciparum malaria in Peru

Brazilian Journal of Infectious Diseases
The efficacy and safety of a fixed-dose combination of atovaquone and proguanil hydrochloride (MalaroneTM) were compared with chloroquine or pyrimethamine/sulfadoxine in patients with acute falciparum malaria in northern Peru.
A. Llanos-Cuentas, P. Campos, M. Clendenes, C. J. Canfield, D. B. A. Hutchinson   +4 more
doaj   +1 more source

Confirmation of emergence of mutations associated with atovaquone-proguanil resistance in unexposed Plasmodium falciparum isolates from Africa

Malaria Journal, 2006
Background In vitro and in vivo resistance of Plasmodium falciparum to atovaquone or atovaquone-proguanil hydrochloride combination has been associated to two point mutations in the parasite cytochrome b (cytb) gene (Tyr268Ser and Tyr268Asn).
Kyle Dennis E, Sowunmi Akintunde, Sarr Ousmane, Milner Danny, Folarin Onikepe A, Gbotosho Grace O, Happi Christian T, Milhous Wilbur K, Wirth Dyann F, Oduola Ayoade MJ   +9 more
doaj   +1 more source