Results 51 to 60 of about 3,667 (197)

Effects of piperaquine, chloroquine, and amodiaquine on drug uptake and of these in combination with dihydroartemisinin against drug-sensitive and -resistant Plasmodium falciparum strains

, 2007
Piperaquine is being developed as a long-acting component in artemisinin combination therapies. It was highly active in vitro and drug interaction studies showed that dihydroartemisinin combinations with piperaquine, chloroquine, and amodiaquine were ...
Adagu, IS, Warhurst, David C, Fivelman, Quinton L, Fivelman, QL, Adagu, Ipemida S, Warhurst, DC   +5 more
core   +1 more source

PBPK‐Led Assessment of Antimalarial Drug Concentrations in Breastmilk: A Strategy for Optimal Use of Prediction Methods to Guide Decision Making in an Understudied Population

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 4, Page 738-750, April 2025.
ABSTRACT Treatment of breastfeeding mothers with malaria is challenging due to the lack of information describing drug exposure in milk and the daily dose to the breastfed infant. Physiologically based pharmacokinetic (PBPK) modeling was used to predict milk‐to‐plasma (M/P) ratios, infant daily doses (IDD) and relative infant doses (RID) for five ...
Lisa M. Almond, Khaled Abduljalil, Amita Pansari, Beata Kusmider, Hannah M. Jones, Karen Rowland Yeo, Iain Gardner, Muhammad Faisal, Anne Claire Marrast, Myriam El Gaaloul, Jörg J. Möhrle, Nada Abla   +11 more
wiley   +1 more source

Constant-ratio combination of atovaquone and proguanil.

, 2017
The dose-response curves for atovaquone (ATQ), proguanil (PG) and the constant-ratio combination of the two drugs (a). Ring stage parasites were treated for 72 hours and analysed using the SG-FCM method.
Jon Deakin (3813211), May Rajab (3813214), Holly Matthews (242183), Maryam Idris-Usman (3813217), Niroshini J. Nirmalan (1275435)   +4 more
core   +1 more source

Deciphering Hepatic Dilemmas: A Case of Acute Hepatitis Following Malaria Treatment

Case Reports in Gastrointestinal Medicine, Volume 2025, Issue 1, 2025.
Malaria can be a life‐threatening disease, but it rarely presents with acute hepatitis. This case reports the medical course of a 55‐year‐old African woman afflicted with P. falciparum malaria, recently treated in Cameroon, who presented with jaundice and transaminitis. Her liver biopsy indicated cholestatic hepatitis.
Sydney Lovrien, Erin Quist, Dayana Maita Coronel, Ashwani K. Singal, Chencheng Xie, Poulami Jha   +5 more
wiley   +1 more source

Gametogenesis in malaria parasites is mediated by the cGMP-dependent protein kinase. [PDF]

, 2008
Malaria parasite transmission requires differentiation of male and female gametocytes into gametes within a mosquito following a blood meal. A mosquito-derived molecule, xanthurenic acid (XA), can trigger gametogenesis, but the signalling events ...
Deng, Wensheng, Baker, David A, Cummings, Ross M., Fivelman, Quinton L, David A Baker, Ross M Cummings, Baker David A, Oliver Billker, Polley Spencer D, Billker Oliver, Billker, Oliver,, Taylor, Cathy J, Fivelman Quinton L, McRobert, Louisa, Spencer D Polley, McRobert Louisa, Polley, Spencer D, Taylor, Cathy J., Billker, Oliver, Taylor Cathy J, Wensheng Deng, Cummings Ross M, Cathy J Taylor, Quinton L Fivelman, Fivelman, Quinton L., Baker, David A., Cummings, Ross M, Louisa McRobert, Deng Wensheng, Polley, Spencer D.   +29 more
core   +1 more source

Lactam Truncation Yields a Dihydroquinazolinone Scaffold with Potent Antimalarial Activity that Targets PfATP4

ChemMedChem, Volume 19, Issue 24, December 16, 2024.
Truncation of the dihydroquinazolinone scaffold produced analogues with potent antimalarial activity against the asexual blood and transmission stages of the malaria parasite's lifecycle by targeting PfATP4. Enhancing the metabolic stability and aqueous solubility remains a challenge to achieve curative efficacy in a mouse model to demonstrate the ...
Trent D. Ashton, Petar P. S. Calic, Madeline G. Dans, Zi Kang Ooi, Qingmiao Zhou, Katie Loi, Kate E. Jarman, Josephine Palandri, Deyun Qiu, Adele M. Lehane, Bikash Maity, Nirupam De, Mufuliat T. Famodimu, Michael J. Delves, Emma Y. Mao, Maria R. Gancheva, Danny W. Wilson, Mrittika Chowdury, Tania F. de Koning‐Ward, Delphine Baud, Stephen Brand, Paul F. Jackson, Alan F. Cowman, Brad E. Sleebs   +23 more
wiley   +1 more source

Effect of SLC22A1 polymorphism on the pharmacokinetics of proguanil in Korean: A semi‐physiologic population pharmacokinetic approach

Clinical and Translational Science, Volume 17, Issue 12, December 2024.
Abstract Proguanil, an antimalarial drug, undergoes hepatic uptake by the polymorphic organic cation transporter 1 (OCT1) and is subsequently metabolized by the cytochrome P‐450 2C19 (CYP2C19) enzyme into its active metabolite, cycloguanil. This study aims to evaluate and mechanistically characterize the effect of genetic polymorphism of SLC22A1, which
Juyoung Khwarg, Eunsol Yang, Chan Song Park, Sang Chun Ji, Kyung‐Sang Yu, SeungHwan Lee   +5 more
wiley   +1 more source

The Plasmodium falciparum sexual development transcriptome: a microarray analysis using ontology-based pattern identification.

, 2005
The sexual stages of malarial parasites are essential for the mosquito transmission of the disease and therefore are the focus of transmission-blocking drug and vaccine development.
Young, Jason A, Baker, David A, Zhou, Yingyao, de la Vega, Patricia, Fivelman, Quinton L, Blair, Peter L, Winzeler, Elizabeth A, Le Roch, Karine G, Carucci, Daniel J   +8 more
core   +1 more source

Activity of piperaquine and other 4-aminoquinoline antiplasmodial drugs against chloroquine-sensitive and resistant blood-stages of Plasmodium falciparum. Role of beta-haematin inhibition and drug concentration in vacuolar water- and lipid-phases. [PDF]

, 2007
Chloroquine (CQ), a 4-aminoquinoline, accumulates in acidic digestive vacuoles of the malaria parasite, preventing conversion of toxic haematin to beta-haematin.
Guy, R Kiplin, Warhurst, David C, Fivelman, Quinton L, Craig, John C, Adagu, Ipemida S, Madrid, Peter B   +5 more
core   +1 more source

Virtue ethics and the unsettled ethical questions in controlled human infection studies

Bioethics, Volume 38, Issue 8, Page 692-701, October 2024.
Abstract Controlled human infection studies (CHIs) involve the intentional infection of human subjects for a scientific aim. Though some past challenge trials have involved serious ethical abuses, in the last few decades, CHIs have had a strong track record of safety.
Jeffrey T. Poomkudy, Seema K. Shah
wiley   +1 more source