Results 61 to 70 of about 3,499 (203)

Drugs that lower the seizure threshold [PDF]

, 2016
Drugs with potential to lower the seizure threshold are numerous and diverse. Whether they contribute to clinically overt seizures depends on the dosage in which they are taken, the time-course of their effects and the susceptibility of the patient ...
Alper, Asenjo Lobos, Benish, Berg, Boison, Cannon, Cardamone, Citraro, Coupland, DeToledo, Foote, Fujimoto, Fukuda, Gayatri, Gholami, Green, Grover, Hill, Ikonomidou-Turski, Jobe, Johannessen Landmark, Kemp, Kumlien, Lauretti, Lertxundi, Lundqvist, Miller, Mink, Nau, Nevin, Park, Raffa, Rantala, Rehni, Rehni, Richens, Sanchez Valiente, Sanchez-Hernandez, Schiemann, Shafaroodi, Sugimoto, Sutter, Tellez-Zenteno, Thundiyil, Varma, Voss, Wallenstein, Whyte, Yoshikawa   +48 more
core   +1 more source

PBPK‐Led Assessment of Antimalarial Drug Concentrations in Breastmilk: A Strategy for Optimal Use of Prediction Methods to Guide Decision Making in an Understudied Population

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 4, Page 738-750, April 2025.
ABSTRACT Treatment of breastfeeding mothers with malaria is challenging due to the lack of information describing drug exposure in milk and the daily dose to the breastfed infant. Physiologically based pharmacokinetic (PBPK) modeling was used to predict milk‐to‐plasma (M/P) ratios, infant daily doses (IDD) and relative infant doses (RID) for five ...
Lisa M. Almond, Khaled Abduljalil, Amita Pansari, Beata Kusmider, Hannah M. Jones, Karen Rowland Yeo, Iain Gardner, Muhammad Faisal, Anne Claire Marrast, Myriam El Gaaloul, Jörg J. Möhrle, Nada Abla   +11 more
wiley   +1 more source

Folic acid treatment of Zambian children with moderate to severe malaria anemia. [PDF]

, 2006
Whether administration of folic acid to children with malaria anemia is helpful is controversial. Therefore, we conducted a randomised, placebo-controlled trial of 14 days of treatment with folic acid (1 mg/d) in Zambian children with malaria anemia ...
Bennett, Steve, Fielding, Katherine, Greenwood, Brian, Malunga, Phidelis, Mulenga, Modest, Shulman, Caroline, Thuma, Philip   +6 more
core   +2 more sources

Deciphering Hepatic Dilemmas: A Case of Acute Hepatitis Following Malaria Treatment

Case Reports in Gastrointestinal Medicine, Volume 2025, Issue 1, 2025.
Malaria can be a life‐threatening disease, but it rarely presents with acute hepatitis. This case reports the medical course of a 55‐year‐old African woman afflicted with P. falciparum malaria, recently treated in Cameroon, who presented with jaundice and transaminitis. Her liver biopsy indicated cholestatic hepatitis.
Sydney Lovrien, Erin Quist, Dayana Maita Coronel, Ashwani K. Singal, Chencheng Xie, Poulami Jha   +5 more
wiley   +1 more source

Atovaquone-proguanil for treating uncomplicated malaria [PDF]

Cochrane Database of Systematic Reviews, 2003
Many conventional treatments for uncomplicated malaria are failing because malaria parasites develop resistance to them. One way to combat this resistance is to treat people with a combination of drugs, such as atovaquone-proguanil.To compare atovaquone-proguanil with other antimalarial drugs (alone or in combination) for treating children and adults ...
A, Osei-Akoto, L, Orton, S P O, Owusu-Ofori   +2 more
openaire   +2 more sources

The antigen presenting potential of Vγ9Vδ2 T-cells during Plasmodium falciparum blood-stage infection. [PDF]

, 2017
During Plasmodium falciparum infections, erythrocyte-stage parasites inhibit dendritic cell maturation and function; compromising development of effective anti-malarial adaptive immunity. Human Vγ9Vδ2 T-cells can act in vitro as APCs and induce αβ T-cell
Behr, Charlotte, Duluc, Dorothée, Duvignaud, Alexandre, Déchanet-Merville, Julie, Eberl, Matthias, Howard, Jennifer, Loizon, Séverine, Malvy, Denis, Mamani-Matsuda, Maria, Mechain, Matthieu, Mercereau-Puijalon, Odile, Moreau, Jean-Francois, Moser, Bernhard, Troye-Blomberg, Marita, Tyler, Christopher J.   +14 more
core   +2 more sources

Lactam Truncation Yields a Dihydroquinazolinone Scaffold with Potent Antimalarial Activity that Targets PfATP4

ChemMedChem, Volume 19, Issue 24, December 16, 2024.
Truncation of the dihydroquinazolinone scaffold produced analogues with potent antimalarial activity against the asexual blood and transmission stages of the malaria parasite's lifecycle by targeting PfATP4. Enhancing the metabolic stability and aqueous solubility remains a challenge to achieve curative efficacy in a mouse model to demonstrate the ...
Trent D. Ashton, Petar P. S. Calic, Madeline G. Dans, Zi Kang Ooi, Qingmiao Zhou, Katie Loi, Kate E. Jarman, Josephine Palandri, Deyun Qiu, Adele M. Lehane, Bikash Maity, Nirupam De, Mufuliat T. Famodimu, Michael J. Delves, Emma Y. Mao, Maria R. Gancheva, Danny W. Wilson, Mrittika Chowdury, Tania F. de Koning‐Ward, Delphine Baud, Stephen Brand, Paul F. Jackson, Alan F. Cowman, Brad E. Sleebs   +23 more
wiley   +1 more source

Effect of SLC22A1 polymorphism on the pharmacokinetics of proguanil in Korean: A semi‐physiologic population pharmacokinetic approach

Clinical and Translational Science, Volume 17, Issue 12, December 2024.
Abstract Proguanil, an antimalarial drug, undergoes hepatic uptake by the polymorphic organic cation transporter 1 (OCT1) and is subsequently metabolized by the cytochrome P‐450 2C19 (CYP2C19) enzyme into its active metabolite, cycloguanil. This study aims to evaluate and mechanistically characterize the effect of genetic polymorphism of SLC22A1, which
Juyoung Khwarg, Eunsol Yang, Chan Song Park, Sang Chun Ji, Kyung‐Sang Yu, SeungHwan Lee   +5 more
wiley   +1 more source

Screening for Mutations Related to Atovaquone/ Proguanil Resistance in Treatment Failures and Other Imported Isolates of Plasmodium falciparum in Europe [PDF]

, 2017
Background. Two single-point mutations of the Plasmodium falciparum cytochrome b gene (Tyr268Asn and Tyr268Ser) were recently reported in cases of atovaquone/proguanil (Malarone) treatment failure.
Alifrangis, Michael, Beran, Jiři, Bisoffi, Zeno, Cuadros, Juan, Cunha, Saraiva da, Ehrhardt, Stephan, Fry, Graham, Gascon, Joaquim, Gjorup, Ida, Grobusch, Martin P., Hatz, Christoph, hlen, Marion Mü, Hoffmann, Gabriele Peyerl, Jelinek, Tomas, Kern, Peter, Kollaritsch, Herwig, Laferl, Hermann, Matteelli, Alberto, McWhinney, Paul, Muehlberger, Nikolai, Richter, Joachim, Schulze, Marco, Wichmann, Ole   +22 more
core  

Virtue ethics and the unsettled ethical questions in controlled human infection studies

Bioethics, Volume 38, Issue 8, Page 692-701, October 2024.
Abstract Controlled human infection studies (CHIs) involve the intentional infection of human subjects for a scientific aim. Though some past challenge trials have involved serious ethical abuses, in the last few decades, CHIs have had a strong track record of safety.
Jeffrey T. Poomkudy, Seema K. Shah
wiley   +1 more source