Results 21 to 30 of about 105,612 (201)

The structural basis for regulation of the glutathione transporter Ycf1 by regulatory domain phosphorylation

Nature Communications, 2022
Ycf1, a C-family member ATP Binding Cassette (ABC) transporter, transports glutathione and glutathione-metal complexes in yeast. Here the authors use cryo-EM and biochemical analysis to show how an intrinsically-disordered regulatory domain (R-domain ...
Nitesh Kumar Khandelwal, Cinthia R. Millan, Samantha I. Zangari, Samantha Avila, Dewight Williams, Tarjani M. Thaker, Thomas M. Tomasiak   +6 more
doaj   +1 more source

Rustless translation [PDF]

, 2012
ATP binding cassette proteins are a large and diverse family of molecular machines and include transmembrane transporter, chromosome maintenance and DNA repair proteins, and translation factors.
Karl-Peter Hopfner, Roy
core   +1 more source

Activation of NLRP3 Inflammasome Promotes Foam Cell Formation in Vascular Smooth Muscle Cells and Atherogenesis Via HMGB1

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
Background This study aimed at investigating whether NLRP3 (the Nod like receptor family, pyrin domain‐containing 3 protein) inflammasome activation induced HMGB1 (high mobility group box‐1 protein) secretion and foam cell formation in human vascular ...
Rui Wang, Weibin Wu, Wen Li, Shuichuan Huang, Zilun Li, Ruiming Liu, Zhen Shan, Chunxiang Zhang, Wen Li, Shenming Wang   +9 more
doaj   +1 more source

An ATP-binding cassette-type cysteine transporter in Campylobacter jejuni inferred from the structure of an extracytoplasmic solute receptor protein [PDF]

, 2005
Campylobacter jejuni is a Gram-negative food-borne pathogen associated with gastroenteritis in humans as well as cases of the autoimmune disease Guillain Barre syndrome. C.
Altekruse, Anthony J. Wilkinson, Axel Müller, Brown, Bryant, Burguiere, Deka, Delaney, During-Olsen, Elena Blagova, Emsley, Fukami-Kobayashi, Gavin H. Thomas, Gouet, Harris, Holland, Hosie, Hosie, James A. Brannigan, Jones, Kaldor, Kazwala, Keith S. Wilson, Kelly, Kertesz, Kraulis, Levdikov, Magnusson, Mark J. Fogg, Martin, Merrell, Merritt, Miller, Murshudov, Newberry, Newcomer, Oh, Oh, Olsen, Palmer, Parkhill, Pawelec, Pawelec, Pei, Pei, Perrakis, Pittman, Richard Horler, Rosef, Schonheyder, Sun, Svedhem, Takahashi, Terwilliger, Vagin, Vargas, Velayudhan, Vladimir M. Levdikov, Walter, Wilkinson, Wyszynska, Yao   +61 more
core   +1 more source

Cryo-EM structures of the ABCA4 importer reveal mechanisms underlying substrate binding and Stargardt disease

Nature Communications, 2021
ABCA4 is an ATP-binding cassette (ABC) transporter that flips N-retinylidenephosphatidylethanolamine (N-Ret-PE) to the cytoplasmic leaflet of photoreceptor membranes. ABCA4 mutations are associated with loss of vision.
Jessica Fernandes Scortecci, Laurie L. Molday, Susan B. Curtis, Fabian A. Garces, Pankaj Panwar, Filip Van Petegem, Robert S. Molday   +6 more
doaj   +1 more source

Boosted coupling of ATP hydrolysis to substrate transport upon cooperative estradiol-17-beta-D-glucuronide binding in a Drosophila ATP binding cassette type-C transporter [PDF]

, 2018
ATP binding cassette type-C (ABCC) transporters move molecules across cell membranes upon hydrolysis of ATP; however, their coupling of ATP hydrolysis to substrate transport remains elusive.
Arányi, Tamás, Karasik, A., Ledwitch, K. V., Roberts, A., Szeri, Flóra, Váradi, András   +5 more
core   +1 more source

Thematic Review Series: Lipid Transfer Proteins ABCG5 and ABCG8: more than a defense against xenosterols

Journal of Lipid Research, 2018
The elucidation of the molecular basis of the rare disease, sitosterolemia, has revolutionized our mechanistic understanding of how dietary sterols are excreted and how cholesterol is eliminated from the body.
Shailendra B. Patel, Gregory A. Graf, Ryan E. Temel   +2 more
doaj   +1 more source

Phosphorylation is required for the pathogen defense function of the Arabidopsis PEN3 ABC transporter. [PDF]

, 2017
The Arabidopsis PEN3 ABC transporter accumulates at sites of pathogen detection, where it is involved in defense against a number of pathogens. Perception of PAMPs by pattern recognition receptors initiates recruitment of PEN3 and also leads to PEN3 ...
Somerville, Shauna, Underwood, William
core   +1 more source

ATP-binding cassette transporter A1: From metabolism to neurodegeneration

Neurobiology of Disease, 2014
ATP-binding cassette transporter A1 (ABCA1) mediates cholesterol efflux to lipid-free apolipoprotein A-I (apoA-I) and apolipoprotein E (apoE). ABCA1 is an essential regulator of high density lipoproteins (HDL) and reverse cholesterol transport — a role ...
Radosveta Koldamova, Nicholas F. Fitz, Iliya Lefterov   +2 more
doaj   +1 more source

ATP-Binding Cassette Transporters, Atherosclerosis, and Inflammation [PDF]

Circulation Research, 2014
Although recent genome-wide association studies have called into question the causal relationship between high-density lipoprotein (HDL) cholesterol levels and cardiovascular disease, ongoing research in animals and cells has produced increasing evidence that cholesterol efflux pathways mediated by ATP-binding cassette (ABC) transporters and HDL ...
Marit, Westerterp, Andrea E, Bochem, Laurent, Yvan-Charvet, Andrew J, Murphy, Nan, Wang, Alan R, Tall   +5 more
openaire   +5 more sources