Results 21 to 30 of about 84,320 (339)

Conservation of structure and mechanism in primary and secondary transporters exemplified by SiaP, a sialic acid binding virulence factor from Haemophilus influenzae [PDF]

, 2006
Extracytoplasmic solute receptors (ESRs) are important components of solute uptake systems in bacteria, having been studied extensively as parts of ATP binding cassette transporters.
Kelly, D.J., Muller, A., Mulligan, C., Severi, E., Thomas, G.H., Watts, A.G., Wilkinson, A.J., Wilson, K.S.   +7 more
core   +2 more sources

ATP Binding Cassette transporters associated with chemoresistance: transcriptional profiling in extreme cohorts and their prognostic impact in a cohort of 281 acute myeloid leukemia patients

Haematologica, 2011
Background A major issue in the treatment of acute myeloid leukemia is resistance to chemotherapeutic drugs. An increasing number of ATP-Binding-Cassette transporters have been demonstrated to cause resistance to cancer drugs.
Christophe Marzac, Edith Garrido, Ruoping Tang, Fanny Fava, Pierre Hirsch, Cinzia De Benedictis, Elise Corre, Simona Lapusan, Jean-Yves Lallemand, Jean-Pierre Marie, Eric Jacquet, Ollivier Legrand   +11 more
doaj   +1 more source

Unidirectional Transport Mechanism in an ATP Dependent Exporter [PDF]

, 2017
ATP-binding cassette (ABC) transporters use the energy of ATP binding and hydrolysis to move a large variety of compounds across biological membranes.
Bernèche, Simon, Seelig, Anna, Xu, Yanyan   +2 more
core   +4 more sources

Boosted coupling of ATP hydrolysis to substrate transport upon cooperative estradiol-17-beta-D-glucuronide binding in a Drosophila ATP binding cassette type-C transporter [PDF]

, 2018
ATP binding cassette type-C (ABCC) transporters move molecules across cell membranes upon hydrolysis of ATP; however, their coupling of ATP hydrolysis to substrate transport remains elusive.
Arányi, Tamás, Karasik, A., Ledwitch, K. V., Roberts, A., Szeri, Flóra, Váradi, András   +5 more
core   +1 more source

Cardiac PET Imaging of ATP Binding Cassette (ABC) Transporters: Opportunities and Challenges

Pharmaceuticals, 2023
Adenosine triphosphate binding cassette (ABC) transporters are a broad family of membrane protein complexes that use energy to transport molecules across cells and/or intracellular organelle lipid membranes. Many drugs used to treat cardiac diseases have
Wanling Liu, Pascalle Mossel, Verena Schwach, Riemer H. J. A. Slart, Gert Luurtsema   +4 more
doaj   +1 more source

Role of ABCG1 and other ABCG family members in lipid metabolism

Journal of Lipid Research, 2001
The molecular cloning and identification of mutations in ATP-binding cassette transporters in hereditary diseases have greatly expanded our knowledge of the normal physiology of intracellular lipid transport processes.
Gerd Schmitz, Thomas Langmann, Susanne Heimerl   +2 more
doaj   +1 more source

A single power stroke by ATP binding drives substrate translocation in a heterodimeric ABC transporter

eLife, 2020
ATP-binding cassette (ABC) transporters constitute the largest family of primary active transporters, responsible for many physiological processes and human maladies.
Erich Stefan, Susanne Hofmann, Robert Tampé   +2 more
doaj   +1 more source

Mutations in the Arabidopsis Peroxisomal ABC Transporter COMATOSE Allow Differentiation between Multiple Functions In Planta: Insights from an Allelic Series [PDF]

, 2008
COMATOSE (CTS), the Arabidopsis homologue of human Adrenoleukodystrophy protein (ALDP), is required for import of substrates for peroxisomal β-oxidation.
Baker, A., Baldwin, J.M., Baldwin, S.A., Dietrich, D., Holdsworth, M.J., Lousa, C.D., Schmuths, H., Theodoulou, F.A.   +7 more
core   +4 more sources

ATP-binding cassette (ABC) transporters in normal and pathological lung

Respiratory Research, 2005
ATP-binding cassette (ABC) transporters are a family of transmembrane proteins that can transport a wide variety of substrates across biological membranes in an energy-dependent manner.
Timmer-Bosscha Hetty, Scheper Rik J, Timens Wim, de Vries Elisabeth GE, van der Deen Margaretha, Postma Dirkje S   +5 more
doaj   +1 more source

Jadomycins: A potential chemotherapy for multi‐drug resistant metastatic breast cancer

Pharmacology Research & Perspectives, 2021
Breast cancer causes the most cancer fatalities in women worldwide. Approximately one‐third of breast cancers metastasize, or spread from primary tumors to other tissues, and have a 70% 5‐year mortality rate.
Esther P. Bonitto, Brendan T. McKeown, Kerry B. Goralski   +2 more
doaj   +1 more source