Results 61 to 70 of about 2,749,588 (276)

Voltage-gated potassium channels as important modulators of glucose-stimulated insulin secretion in pancreatic β-cells: insights from rodent and human studies

Frontiers in Endocrinology
Insulin secretion from pancreatic islet β-cells is governed by both metabolic and electrogenic pathways. The latter involves changes in membrane potential regulated by various potassium channels, including ATP-sensitive K+ (KATP) channels, Ca2+-sensitive
Jing-Jing Xing, Jing-Jing Xing, Chen Chen   +2 more
doaj   +1 more source

The Methanolic Extract from Murraya koenigii L. Inhibits Glutamate-Induced Pain and Involves ATP-Sensitive K+ Channel as Antinociceptive Mechanism

Advances in Pharmacological Sciences, 2016
Murraya koenigii L. is a perennial shrub, belonging to the family Rutaceae. Traditionally, the leaves of this plant are extensively used in treatment of a wide range of diseases and disorders including pain and inflammation.
Nushrat Sharmin Ani, Sudip Chakraborty, Md. Moniruzzaman   +2 more
doaj   +1 more source

The hydroxypropyl‐β‐cyclodextrin‐minoxidil inclusion complex improves the cardiovascular and proliferative adverse effects of minoxidil in male rats: Implications in the treatment of alopecia

Pharmacology Research & Perspectives, 2020
The efficacy of minoxidil (MXD) ethanolic solutions (1%‐5% w/v) in the treatment of androgenetic alopecia is limited by adverse reactions. The toxicological effects of repeated topical applications of escalating dose (0.035%‐3.5% w/v) and of single and ...
Fatima Maqoud, Nicola Zizzo, Antonietta Mele, Nunzio Denora, Giuseppe Passantino, Rosa Scala, Annalisa Cutrignelli, Antonella Tinelli, Valentino Laquintana, Flavia laForgia, Sergio Fontana, Massimo Franco, Angela Assunta Lopedota, Domenico Tricarico   +13 more
doaj   +1 more source

Do anionic phospholipids serve as cofactors or second messengers for the regulation of activity of cloned ATP-sensitive K+ channels? [PDF]

, 2003
The regulation of ion channels by anionic phospholipids is currently very topical. An outstanding issue is whether phosphatidylinositol 4,5-diphosphate and related species act as true second messengers in signaling or behave in a manner analogous to an ...
Quinn, KV, Giblin, JP, Clapp, LH, Tinker, A, Cui, Y   +4 more
core  

DNA‐Templated 2D Heterostructures as Phototriggered Dynamic Nanohybrids: From Releasing Molecular Loads to Controlling Enzyme Biocatalytic Function

Advanced Functional Materials, EarlyView.
DNA strands are employed both as dynamic linkers and nanoscale templates for the integration of Ag2S nanoparticles on MoS2, which in turn imparted photothermal responsiveness; this feature permits the selective cargo (fluorophore, quantum dots or an enzyme) release from the MoS2 surface in response to local heat induced by light irradiation.
Kai Chen, Haosen Miao, Weiying Hong, Matteo Palma   +3 more
wiley   +1 more source

ATP-Sensitive Potassium Channel and Hormone/Neuropeptide

Folia Endocrinologica Japonica, 1995
ATP-sensitive potassium channels (KATP) are the ion channels which are closely associated with cellular metabolism. A number of chemical compounds which block KATP facilitate the release of hormones or neuropeptides. For example, KATP-blocking agents such as antidiabetic sulfonylureas and imidazolines stimulate insulin secretion from pancreatic beta ...
openaire   +3 more sources

The distribution and function of the ATP-sensitive potassium channel subunit Kir6.1 in cardiac and skeletal muscle cell lines. [PDF]

, 2007
ATP-sensitive potassium channels (KAtp) are present in the plasma membrane of a number of tissues but are also present on endomembranes such as the endoplasmic reticulum (ER) and mitochondria.
Ng, K-E.
core  

Leptin-dependent Phosphorylation of PTEN Mediates Actin Restructuring and Activation of ATP-sensitive K+ Channels [PDF]

, 2009
Leptin activates multiple signaling pathways in cells, including the phosphatidylinositol 3-kinase pathway, indicating a degree of cross-talk with insulin signaling. The exact mechanisms by which leptin alters this signaling pathway and how it relates to
Miller, L.C., Sutherland, C., Sutherland, Calum, Gallagher, J., Miller, Lisa C., Ashford, M.L.J., Ning, K., Laidlaw, Hilary A., Watterson, Kenneth R., Sutherland, Calum; id_orcid, Laidlaw, H.A., Ning, Ke, Ashford, Michael L. J.; id_orcid, Watterson, K.R., Gallagher, Jennifer, Ashford, Michael L.J.   +15 more
core   +1 more source

Intermediate Resistive State in Wafer‐Scale Vertical MoS2 Memristors Through Lateral Silver Filament Growth for Artificial Synapse Applications

Advanced Functional Materials, EarlyView.
In MOCVD MoS2 memristors, a current compliance‐regulated Ag filament mechanism is revealed. The filament ruptures spontaneously during volatile switching, while subsequent growth proceeds vertically through the MoS2 layers and then laterally along the van der Waals gaps during nonvolatile switching.
Yuan Fa, Milan Buttberg, Ke Ran, Rana Walied Ahmad, Dennis Braun, Lukas Völkel, Jimin Lee, Sofía Cruces, Bart Macco, Bárbara Canto, Holger Lerch, Thorsten Wahlbrink, Holger Kalisch, Michael Heuken, Andrei Vescan, Joachim Mayer, Zhenxing Wang, Ilia Valov, Stephan Menzel, Max C. Lemme   +19 more
wiley   +1 more source

Kir6.1, a component of an ATP-sensitive potassium channel, regulates natural killer cell development

Frontiers in Immunology
IntroductionInvolved in immunity and reproduction, natural killer (NK) cells offer opportunities to develop new immunotherapies to treat infections and cancer or to alleviate pregnancy complications. Most current strategies use cytokines or antibodies to
Natalie Samper, Lilja Hardardottir, Delphine M. Depierreux, Soomin C. Song, Ayano Nakazawa, Ivan Gando, Tomoe Y. Nakamura, Andrew M. Sharkey, Carla R. Nowosad, Stefan Feske, Francesco Colucci, William A. Coetzee, William A. Coetzee, William A. Coetzee   +13 more
doaj   +1 more source