Results 61 to 70 of about 45,380 (194)

Structure based analysis of KATP channel with a DEND syndrome mutation in murine skeletal muscle

Scientific Reports, 2021
Developmental delay, epilepsy, and neonatal diabetes (DEND) syndrome, the most severe end of neonatal diabetes mellitus, is caused by mutation in the ATP-sensitive potassium (KATP) channel.
Shoichiro Horita, Tomoyuki Ono, Saul Gonzalez-Resines, Yuko Ono, Megumi Yamachi, Songji Zhao, Carmen Domene, Yuko Maejima, Kenju Shimomura   +8 more
doaj   +1 more source

Participação de canais de potássio no desenvolvimento do processo inflamatório e nas alterações cardiovasculares que ocorrem durante a sepse/choque séptico [PDF]

, 2009
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em Farmacologia.O óxido nítrico (NO) é um dos principais mediadores da vasodilatação e hiporeatividade a vasoconstritores que ocorre
Sordi, Regina de
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ATP-sensitive potassium channel (K_ATP channel) expression in the normal canine pancreas and in canine insulinomas

BMC Veterinary Research, 2005
Background Pancreatic beta cells express ATP-sensitive potassium (KATP) channels that are needed for normal insulin secretion and are targets for drugs that modulate insulin secretion. The KATP channel is composed of two subunits: a sulfonylurea receptor
Kidder Aimee C, Hiskett Erin K, Donley Vicky R, Schermerhorn Thomas   +3 more
doaj   +1 more source

KCNE1 and KCNE2 provide a checkpoint governing voltage-gated potassium channel α-subunit composition [PDF]

, 2011
Voltage-gated potassium (Kv) currents generated by N-type α-subunit homotetramers inactivate rapidly because an N-terminal ball domain blocks the channel pore after activation.
Abbott, G., Xu, Xianghua, Geoffrey W. Abbott, Kanda, Vikram A, Abbott, Geoffrey W, Anthony Lewis, Vikram A. Kanda, Xianghua Xu, Lewis, Anthony, Kanda, Vikram A., Xianghua, X., Kanda, V., Abbott, Geoffrey W.   +12 more
core   +1 more source

KATP channels in cerebral hemodynamics: a systematic review of preclinical and clinical studies

Frontiers in Neurology
Cumulative evidence suggests that ATP-sensitive potassium (KATP) channels act as a key regulator of cerebral blood flow (CBF). This implication seems to be complicated, since KATP channels are expressed in several vascular-related structures such as ...
Hassan Ali Suleiman Daoud, Lili Kokoti, Mohammad Al-Mahdi Al-Karagholi, Mohammad Al-Mahdi Al-Karagholi, Mohammad Al-Mahdi Al-Karagholi   +4 more
doaj   +1 more source

Mitochondrial potassium channel opener diazoxide preserves neuronal-vascular function after cerebral ischemia in newborn pigs

, 1999
Background and Purpose-N-Methyl-D-aspartate (NMDA) elicits neuronally mediated cerebral arteriolar vasodilation that is reduced by ischemia/reperfusion (I/R).
David W. Busija, Perciaccante, J. V., Ferenc Domoki, James V. Perciaccante, Domoki, Ferenc, Bari, Ferenc, Ferenc Bari, Roland Veltkamp, Veltkamp, R.   +8 more
core   +1 more source

ATP-sensitive and inwardly rectifying potassium channels in smooth muscle

, 1997
The properties and roles of ATP-sensitive (K(ATP)) and inwardly rectify (K(IR)) potassium channels are reviewed. Potassium channels regulate the membrane potential of smooth muscle, which controls calcium entry through voltage-dependent calcium channels,
Nelson, M. T.; id_orcid, Standen, N. B., Quayle, J. M.   +2 more
core   +2 more sources

ATP-Sensitive Potassium Channel

The aim of this chapter is to delve comprehensively into ATP-sensitive potassium (KATP) channel, which is a ubiquitous class of potassium ion channels located in the biological membrane to sense intracellular nucleotide (ATP/ADP) concentration and mediate potassium efflux in various cell types (and mitochondria), thus functions as a link between ...
Hua-Qian Yang, Shuhan Che, Jianyi Huo, Qianqian Yang   +3 more
openaire   +1 more source

The distribution and function of the ATP-sensitive potassium channel subunit Kir6.1 in cardiac and skeletal muscle cell lines.

, 2007
ATP-sensitive potassium channels (KAtp) are present in the plasma membrane of a number of tissues but are also present on endomembranes such as the endoplasmic reticulum (ER) and mitochondria.
Ng, K-E.
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Do anionic phospholipids serve as cofactors or second messengers for the regulation of activity of cloned ATP-sensitive K+ channels?

, 2003
The regulation of ion channels by anionic phospholipids is currently very topical. An outstanding issue is whether phosphatidylinositol 4,5-diphosphate and related species act as true second messengers in signaling or behave in a manner analogous to an ...
Quinn, KV, Giblin, JP, Clapp, LH, Tinker, A, Cui, Y   +4 more
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