Results 51 to 60 of about 45,380 (194)

Potassium channels in prostate and colonic cancer

, 2007
Large conductance Ca2+-activated K+ channels in human prostate cancer The KCNMA1 gene encoding the alpha-subunit of BK channels is amplified and BK channel expression is enhanced in late-stage, metastatic and hormone-refractory human prostate cancer ...
Ousingsawat, Jiraporn
core   +1 more source

Cromakalim (BRL 34915) restores in vitro the membrane potential of depolarized human skeletal muscle fibres [PDF]

, 1989
The purpose of the present study was to analyze the effects of cromakalim (BRL 34915), a potent drug from a new class of drugs characterized as K+ channel openers, on the electrical activity of human skeletal muscle.
Lehmann-Horn, Frank, Grafe, Peter, Spuler, A.   +2 more
core   +1 more source

Increase of ATP-sensitive potassium (K_ATP) channels in the heart of type-1 diabetic rats

Cardiovascular Diabetology, 2012
Background An impairment of cardiovascular function in streptozotocin (STZ)-diabetic rats has been mentioned within 5 days-to-3 months of induction. ATP-sensitive potassium (KATP) channels are expressed on cardiac sarcolemmal membranes.
Chen Zhih-Cherng, Cheng Yung-Ze, Chen Li-Jen, Cheng Kai-Chun, Li Yin-, Cheng Juei-   +5 more
doaj   +1 more source

The reversible effects of free fatty acids on sulfonylurea-stimulated insulin secretion are related to the expression and dynamin-mediated endocytosis of KATP channels in pancreatic β cells

Endocrine Connections, 2022
Objective: Lipotoxicity-induced pancreatic β cell-dysfunction results in decreased insulin secretion in response to multiple stimulus. In this study, we i nvestigated the reversible effects of palmitate (PA) or oleate (OA) on insulin secretion and the ...
Chenmin Wei, Zichen Zhang, Qi Fu, Yunqiang He, Tao Yang, Min Sun   +5 more
doaj   +1 more source

Simulating PIP2-Induced Gating Transitions in Kir6.2 Channels

Frontiers in Molecular Biosciences, 2021
ATP-sensitive potassium (KATP) channels consist of an inwardly rectifying K+ channel (Kir6.2) pore, to which four ATP-sensitive sulfonylurea receptor (SUR) domains are attached, thereby coupling K+ permeation directly to the metabolic state of the cell ...
Michael Bründl, Sarala Pellikan, Anna Stary-Weinzinger   +2 more
doaj   +1 more source

Kir6.1, a component of an ATP-sensitive potassium channel, regulates natural killer cell development

Frontiers in Immunology
IntroductionInvolved in immunity and reproduction, natural killer (NK) cells offer opportunities to develop new immunotherapies to treat infections and cancer or to alleviate pregnancy complications. Most current strategies use cytokines or antibodies to
Natalie Samper, Lilja Hardardottir, Delphine M. Depierreux, Soomin C. Song, Ayano Nakazawa, Ivan Gando, Tomoe Y. Nakamura, Andrew M. Sharkey, Carla R. Nowosad, Stefan Feske, Francesco Colucci, William A. Coetzee, William A. Coetzee, William A. Coetzee   +13 more
doaj   +1 more source

Upregulation of ATP-Sensitive Potassium Channels as the Potential Mechanism of Cardioprotection and Vasorelaxation Under the Action of Pyridoxal-5-Phosphate in Old Rats

Journal of Cardiovascular Pharmacology and Therapeutics, 2023
Background: The aging process is accompanied by the weakening of the protective systems of the organism, in particular by the decrease in the expression of ATP-sensitive potassium (K ATP ) channels and in the synthesis of H 2 S.
Ruslan B. Strutynskyi PhD, DSc, Nataliіa A. Strutynska PhD, Oksana O. Piven PhD, DSc, Lidiia A. Mys PhD, Yulia V. Goshovska PhD, Raisa A. Fedichkina PhD, Iryna Y. Okhai (postgraduate), Vladyslav R. Strutynskyi PhD student, Victor E. Dosenko MD, PhD, DSc, Pawel Dobrzyn PhD, DSc, Vadim F. Sagach MD, PhD, DSc   +10 more
doaj   +1 more source

ATP-Sensitive Potassium Channel and Hormone/Neuropeptide

Folia Endocrinologica Japonica, 1995
ATP-sensitive potassium channels (KATP) are the ion channels which are closely associated with cellular metabolism. A number of chemical compounds which block KATP facilitate the release of hormones or neuropeptides. For example, KATP-blocking agents such as antidiabetic sulfonylureas and imidazolines stimulate insulin secretion from pancreatic beta ...
openaire   +3 more sources

N-glycosylation-dependent control of functional expression of background potassium channels K2P3.1 and K2P9.1

, 2013
Two-pore domain potassium (K2P) channels play fundamental roles in cellular processes by enabling a constitutive leak of potassium from cells in which they are expressed, thus influencing cellular membrane potential and activity.
Roncoroni, Laura, Lowry, Eleanor, Johnson, Daniel, O'Kelly, Ita, Williams, Sarah, Mant, Alexandra   +5 more
core   +1 more source

Molecular Bases of Brain Preconditioning

Frontiers in Neuroscience, 2017
Preconditioning of the brain induces tolerance to the damaging effects of ischemia and prevents cell death in ischemic penumbra. The development of this phenomenon is mediated by mitochondrial adenosine triphosphate-sensitive potassium (KATP+) channels ...
Oleg G. Deryagin, Svetlana A. Gavrilova, Khalil L. Gainutdinov, Khalil L. Gainutdinov, Anna V. Golubeva, Vyatcheslav V. Andrianov, Vyatcheslav V. Andrianov, Guzel G. Yafarova, Guzel G. Yafarova, Sergey V. Buravkov, Vladimir B. Koshelev   +10 more
doaj   +1 more source