Results 41 to 50 of about 1,799,367 (292)

Targeting the Key Enzymes of Abnormal Fatty Acid β-oxidation as a Potential Strategy for Tumor Therapy

Frontiers in Bioscience-Landmark, 2022
Fatty acid metabolism has attracted extensive attention for its key role in the occurrence and development of tumors. Fatty acids not only participate in the biosynthesis of phospholipids in the membrane to overcome the demand for rapidly proliferating ...
Hongdan Chen, Zeyu Yang, Yiceng Sun, Supeng Yin, Mi Tang, Fan Zhang   +5 more
doaj   +1 more source

Nanoscale ATP-Responsive Zeolitic Imidazole Framework-90 as a General Platform for Cytosolic Protein Delivery and Genome Editing.

Journal of the American Chemical Society, 2019
Metal-organic frameworks (MOFs) are an emerging class of nanocarriers for drug delivery, owing to their tunable chemical functionality. Here we report ATP-responsive zeolitic imidazole framework-90 (ZIF-90) as a general platform for cytosolic protein ...
Xiaoti Yang, Qiao Tang, Ying Jiang, Meining Zhang, Ming Wang, L. Mao   +5 more
semanticscholar   +1 more source

Temperature-dependent release of ATP from human erythrocytes: Mechanism for the control of local tissue perfusion [PDF]

, 2012
Copyright @ 2012 The AuthorsThis article has been made available through the Brunel Open Access Publishing Fund.Human limb muscle and skin blood flow increases significantly with elevations in temperature, possibly through physiological processes that ...
Abraham, Akyurekli, Baar, Barcroft, Bazett, Bergfeld, Black, Cheng, Coade, Cripps, Denning, Deussen, Dill, Duc, Dufour, Ellsworth, Feliciano, Fischer, González-Alonso, González-Alonso, González-Alonso, Gordon, Gorman, Gorman, Gourine, Green, He, José González-Alonso, Kameljit K. Kalsi, Keller, Kirby, Kirby, Llaudet, Locovei, Malinauskas, Mortensen, Mortensen, Mortensen, Niimi, Olearczyk, Pearson, Ray, Rosenmeier, Rowell, Ruiter, Saltin, Schrage, Scott-Ward, Sheppard, Sprague, Sprague, Sridharan, Sterling, Tu, Williamson, Yegutkin, Yegutkin, Zimmermann, Zimmermann   +58 more
core   +2 more sources

Intracellular Adenosine Triphosphate (ATP) Concentration: A Switch in the Decision Between Apoptosis and Necrosis

Journal of Experimental Medicine, 1997
Apoptosis and necrosis are considered conceptually and morphologically distinct forms of cell death. Here, we report that demise of human T cells caused by two classic apoptotic triggers (staurosporin and CD95 stimulation) changed from apoptosis to ...
M. Leist, B. Single, A. Castoldi, Simone Kühnle, P. Nicotera   +4 more
semanticscholar   +1 more source

Self‐Calibrating Ratiometric DNA Aptamer Probe for Quantitative ATP Imaging in Living Cells

Chemistry – A European Journal, EarlyView.
We developed the RFA–ECHO probe, an internally calibrated ATP sensor that remains responsive across millimolar ATP levels. Its self‐correcting Cy5/ECHO ratio ensures accurate quantification independent of probe uptake. Compared with FRET‐based sensors, it yields a robust ratiometric shift, distinguishing high‐ATP cancer cells from normal ones, enabling
Yunsong Xu, Kunihiko Morihiro, Rui Cong, Samruddhi Maheshwar Patil, Idoia Wille, Akimitsu Okamoto   +5 more
wiley   +1 more source

Intranasal Mitochondrial Transplantation Restores Mitochondrial Function and Modulates Glial–Neuronal Interactions in a Genetic Parkinson’s Disease Model of UQCRC1 Mutation

Cells
The intranasal delivery of exogenous mitochondria is a potential therapy for Parkinson’s disease (PD). The regulatory mechanisms and effectiveness in genetic models remains uncertain, as well as the impact of modulating the mitochondrial permeability ...
Jui-Chih Chang, Chin-Hsien Lin, Cheng-Yi Yeh, Mei-Fang Cheng, Yi-Chieh Chen, Chi-Han Wu, Hui-Ju Chang, Chin-San Liu   +7 more
doaj   +1 more source

Tomato Spotted Wilt Virus Reprogrammes Host Glycolysis to Facilitate Proliferation by a Phase‐Separated Co‐Aggregate of Nucleocapsid Protein and Phosphoglycerate Kinase

Plant Biotechnology Journal, EarlyView.
ABSTRACT Efficient viral proliferation within the host is a critical step in pathogenicity and requires adenosine triphosphate (ATP). The replication, movement and immune evasion of many plant viruses within their hosts are associated with phase separation (PS)‐derived aggregates formed by viral components.
Guangcheng Zu, Zhifu Xing, Jiao Li, Tangbing Yang, Huan Wu, Qiangsheng Ge, Yanju Wang, Baoan Song, Runjiang Song   +8 more
wiley   +1 more source

A new type of Na+-driven ATP synthase membrane rotor with a two-carboxylate ion-coupling motif [PDF]

, 2013
: The anaerobic bacterium Fusobacterium nucleatum uses glutamate decarboxylation to generate a transmembrane gradient of Na+. Here, we demonstrate that this ion-motive force is directly coupled to ATP synthesis, via an F1Fo-ATP synthase with a novel Na ...
Faraldo-Gómez, José D., Iglesias-Cans, Marina, Krah, Alexander, Leone, Vanessa, M. Cook, Gregory, Matthies, Doreen, Meier, Thomas, Schulz, Sarah, Yildiz, Özkan   +8 more
core   +3 more sources

Distinct profiles of mitochondrial bioenergetics and redox balance in left atrial and ventricular myocardium in the healthy rat heart

Experimental Physiology, EarlyView.
Abstract The left ventricle (LV) is the primary pumping chamber of the heart, generating high systolic pressure to sustain systemic circulation. LV contractile dysfunction is a hallmark of various cardiovascular diseases and is associated with mitochondrial dysfunction, characterised by decreased oxidative phosphorylation (OXPHOS) capacity and ...
Tingting Fang, Alex Chan, Janice Chew‐Harris, Toan Pham   +3 more
wiley   +1 more source

Elleborus in Anglo-Saxon England, 900–1100: Tunsingwyrt and Wodewistle [PDF]

, 2013
This article examines the meanings of the Latin word elleborus in later Anglo-Saxon England. They prove to have varied, from Ælfric’s implicit assertion around 1000 that elleborus had no vernacular Old English counterpart, to the association by the ...
Hall, ATP
core