Results 41 to 50 of about 26,623 (99)

Closing a Key Gap in DSCSA Compliance with Credentialing

Blockchain in Healthcare Today, 2023
In this session, the Open Credentialing Initiative (OCI) introduces the concept and practical application of electronic credentials. The audience will learn about their use in the context of DSCSA and how they enable timely compliance with the DSCSA ...
Bob Celeste, David Kessler
doaj   +1 more source

Deficiency of Microglial‐Derived Spp1 Exacerbates Age‐Related Memory Decline by Impairing Mitochondrial Complex I Function

Aging Cell, Volume 25, Issue 2, February 2026.
Microglia‐derived Spp1 regulates OXPHOS via the AKT/Complex I pathway to mitigate age‐related memory decline. (Graphical Abstract was created using BioRender). ABSTRACT Age‐related memory decline is a hallmark of brain aging and a primary risk factor for neurodegenerative disorders.
Meiling Wang, Yumin Chang, Aojie He, Jing Yang, Ang Li, Hongqin Wang, Kah‐Leong Lim, Xing Guo, Chengwu Zhang, Li Lu   +9 more
wiley   +1 more source

A new electoral bottom-up model of institutional governance

Scientific Reports
The sustainable governance of Global Risky Commons (GRC)—global commons in the presence of a sizable risk of overall failure—is ubiquitous and requires a global solution. A prominent example is the mitigation of the adverse effects of global warming.
Carlos M. Garrido, Francisco C. Santos, Elias Fernández Domingos, Ana M. Nunes, Jorge M. Pacheco   +4 more
doaj   +1 more source

KIAA0753 promotes glucose and energy metabolism in osteoblasts inhibited by diabetes

陆军军医大学学报
Objective To explore the effect of KIAA0753 on glucose and energy metabolism in mouse embryonic osteoblast precursor cell line MC3T3-E1. Methods The GSE182286 datasets of patients with Joubert syndrome acquired from the Gene Expression Comprehensive ...
LI Mengxue, LI Mengxue, WANG Jichun, WANG Jichun, LI Letai   +4 more
doaj   +1 more source

Photo‐Empowered Macrophage‐Based Drug Delivery System Overcomes Motility Suppression and Significantly Enhances Deep Tumor Drug Delivery

Advanced Science, Volume 13, Issue 5, 27 January 2026.
This study develops a photo‐empowered macrophage‐based (PEM) drug delivery system that provides a novel and effective solution for restoring cellular motility to enhance drug delivery and overcome hypoxia‐induced multidrug resistance. The construction of the PEM system fully exploits the unique biological properties of macrophages and the energy ...
Zhaoming Fu, Xin Cui, Shanshan Liu, Lu Gao, Yingang Sun, Yujun Chen, Mianlong Li, Yuxin Fan, Jing Kuang, Wen Song, Feifan Zhou   +10 more
wiley   +1 more source

Quercetin and histamine effects of the content of superoxide anion and ATP in the blood plasma of rats

Біологічні студії, 2023
Background. Histamine is one of the versatile biogenic amines with multiple roles in the immune response and allergic disorders. Histamine and ATP can act as ligands in the body.
Nataliya Harasym, Victoria Grondzal, Nataliia Bodnarchuk, Alina Zyn, Svitlana Mandzynets, Anastasiia Heneha   +5 more
doaj   +1 more source

ATP Cellotoxicity, ATP-Induced Cell Death and ATP Depletion

International Journal of Public Health and Medical Research
This paper delves into three pivotal themes concerning adenosine triphosphate (ATP): ATP cytotoxicity, ATP-induced cell death, and ATP depletion. Initially, we scrutinize ATP's involvement in cytotoxicity, with a specific focus on elucidating the mechanisms underlying cell demise triggered by augmented extracellular ATP concentrations. Subsequently, we
Haoling Zhang, Haolong Zhang, Rui Zhao, Doblin Sandai, Zhijing Song, Zhongwen Zhang, Wei Wang   +6 more
openaire   +1 more source

The Three Pillars of ATP Production in Mammalian Sperm: Integrating Gluconeogenesis Into the Metabolic Framework

Reproductive Medicine and Biology, Volume 25, Issue 1, January/December 2026.
ABSTRACT Purpose Mammalian sperm require a large amount of ATP to sustain motility. While glycolysis and oxidative phosphorylation (OXPHOS) are established ATP sources, they cannot fully explain motility maintenance under glucose‐deprived conditions.
Kosei Oishi, Reiji Tokito, Yasushi Yumura, Manabu Yoshida, Kaoru Yoshida, Masatsugu Asada, Koyuki Mikami, Hiroyuki Watanabe, Yuki Muranishi, Yasuyuki Kurihara   +9 more
wiley   +1 more source

Characterization of the phosphotransacetylase-acetate kinase pathway for ATP production in Porphyromonas gingivalis

Journal of Oral Microbiology, 2019
Acetyl phosphate (AcP) is generally produced from acetyl coenzyme A by phosphotransacetylase (Pta), and subsequent reaction with ADP, catalyzed by acetate kinase (Ack), produces ATP.
Yasuo Yoshida, Mitsunari Sato, Takamasa Nonaka, Yoshiaki Hasegawa, Yuichiro Kezuka   +4 more
doaj   +1 more source

A Systematic Review of the Expression, Signalling and Function of P2 Receptors in Primary Bone Cancer

Frontiers in Bioscience-Landmark, 2022
Primary bone cancers are rare malignant diseases with significant morbidity and mortality. The treatment regimen relies on a combination of surgery (often involving amputation), chemotherapy and radiotherapy with outcomes dependent on localization of the
Luke Tattersall, Dan C Gagui, Victoria L Tippett, Norain B Ab Latif, Karan M Shah, Alison Gartland   +5 more
doaj   +1 more source