Results 51 to 60 of about 1,799,367 (292)

Extracellular ATP drives systemic inflammation, tissue damage and mortality [PDF]

, 2014
Systemic inflammatory response syndromes (SIRS) may be caused by both infectious and sterile insults, such as trauma, ischemia-reperfusion or burns. They are characterized by early excessive inflammatory cytokine production and the endogenous release of ...
Brouckaert, Peter, Cauwels, Anje, Rogge, Elke, Shiva, S, Vandendriessche, Benjamin   +4 more
core   +1 more source

Formoterol Acting via β2-Adrenoreceptor Restores Mitochondrial Dysfunction Caused by Parkinson’s Disease-Related UQCRC1 Mutation and Improves Mitochondrial Homeostasis Including Dynamic and Transport

Biology
Formoterol, a β2-adrenergic receptor (β2AR) agonist, shows promise in various diseases, but its effectiveness in Parkinson’s disease (PD) is debated, with unclear regulation of mitochondrial homeostasis.
Jui-Chih Chang, Huei-Shin Chang, Yi-Chun Chao, Ching-Shan Huang, Chin-Hsien Lin, Zhong-Sheng Wu, Hui-Ju Chang, Chin-San Liu, Chieh-Sen Chuang   +8 more
doaj   +1 more source

Energetic microdomains and the vascular control of neuronal and muscle excitability: Toward a unified model

The Journal of Physiology, EarlyView.
Abstract figure legend The capillary–mitochondria–ion channel (CMIC) axis scales structural resources to match functional workload. (Left) In settings of restricted energetic capacity (e.g. cortical neurons), sparse capillary networks and modest mitochondrial pools set a lower energetic ceiling, sufficient to support phasic, low‐workload excitability. (
L. Fernando Santana, Scott Earley
wiley   +1 more source

Madness, Medication--and Self-Induced Hallucination? Elleborus (and Woody Nightshade) in Anglo-Saxon England, 700-900 [PDF]

, 2013
This article studies what Anglo-Saxons in around 700--900 understood by the Latin plant-name elleborus, looking particularly at Aldhelm's Latin riddle Elleborus, which suggests that the word was understood to denote woody nightshade (Solanum dulcamara ...
Hall, ATP
core  

α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease

Nature Communications, 2018
Protein aggregation causes α-synuclein to switch from its physiological role to a pathological toxic gain of function. Under physiological conditions, monomeric α-synuclein improves ATP synthase efficiency.
M. H. Ludtmann, Plamena R. Angelova, M. Horrocks, Minee L. Choi, M. Rodrigues, Artyom Y. Baev, A. V. Berezhnov, Z. Yao, Daniel Little, B. Banushi, A. Al-Menhali, Rohan T. Ranasinghe, Daniel R. Whiten, Ratsuda Yapom, K. S. Dolt, Michael J. Devine, P. Gissen, T. Kunath, Morana Jaganjac, E. Pavlov, D. Klenerman, A. Abramov, S. Gandhi   +22 more
semanticscholar   +1 more source

Deficiency of Microglial‐Derived Spp1 Exacerbates Age‐Related Memory Decline by Impairing Mitochondrial Complex I Function

Aging Cell, Volume 25, Issue 2, February 2026.
Microglia‐derived Spp1 regulates OXPHOS via the AKT/Complex I pathway to mitigate age‐related memory decline. (Graphical Abstract was created using BioRender). ABSTRACT Age‐related memory decline is a hallmark of brain aging and a primary risk factor for neurodegenerative disorders.
Meiling Wang, Yumin Chang, Aojie He, Jing Yang, Ang Li, Hongqin Wang, Kah‐Leong Lim, Xing Guo, Chengwu Zhang, Li Lu   +9 more
wiley   +1 more source

Jón the Fleming: Low German in Thirteenth-Century Norway and Fourteenth-Century Iceland [PDF]

, 2014
Low German influence is one of the most prominent characteristics of Old Norse in the later medieval period, but the processes whereby this took place are little evidenced.
Hall, ATP
core  

Coexpression of rat P2X2 and P2X6 subunits in Xenopus oocytes. [PDF]

, 2000
Transcripts for P2X(2) and P2X(6) subunits are present in rat CNS and frequently colocalize in the same brainstem nuclei. When rat P2X(2) (rP2X(2)) and rat P2X(6) (rP2X(6)) receptors were expressed individually in Xenopus oocytes and studied under ...
Burnstock, G, King, B F, Spyer, K M, Thomas, T, Townsend-Nicholson, A, Wildman, Scott S.P.   +5 more
core   +1 more source

A new electoral bottom-up model of institutional governance

Scientific Reports
The sustainable governance of Global Risky Commons (GRC)—global commons in the presence of a sizable risk of overall failure—is ubiquitous and requires a global solution. A prominent example is the mitigation of the adverse effects of global warming.
Carlos M. Garrido, Francisco C. Santos, Elias Fernández Domingos, Ana M. Nunes, Jorge M. Pacheco   +4 more
doaj   +1 more source

Comportamento do sistema de aterramento de LDs 69 kV com estruturas de concreto sob descargas atmosféricas

Revista Principia, 2013
Este trabalho analisa o comportamento do sistema de aterramento de Linhas de Distribuição de 69kV com estruturas de concreto dotadas de cabo para-raios quando submetidas a descargas atmosféricas. Neste estudo, foram modelados com a utilização do software
Antonio dos Santos Dália, Franklin Martins Pamplona, José Tavares de Oliveira   +2 more
doaj   +1 more source