Results 51 to 60 of about 26,623 (99)

P2X7 receptor antagonism suppresses epileptiform‐like activity in an inflammation‐primed human iPSC‐derived neuron model of drug‐resistant epilepsy

British Journal of Pharmacology, Volume 183, Issue 2, Page 296-312, January 2026.
Background and Purpose Neuroinflammation is increasingly recognised to contribute to drug‐resistant epilepsy. Activation of ATP‐gated P2X7 receptors has emerged as an important upstream mechanism, and increased P2X7 receptor expression is present in the seizure focus in rodent models and patients. Pharmacological antagonists of P2X7 receptors attenuate
Jaideep Kesavan, Yitao Wang, Klaus Dinkel, Michael Hamacher, Jochen H. M. Prehn, David C. Henshall, Tobias Engel   +6 more
wiley   +1 more source

The Role of Heat Shock Protein 70 kDa in Asthma

Journal of Asthma and Allergy, 2021
Marina Shevchenko,1 Ekaterina Servuli,1,2 Zarema Albakova,1,3 Leonid Kanevskiy,1 Alexander Sapozhnikov1,3 1Department of Immunology, Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia; 2Department of ...
Shevchenko M, Servuli E, Albakova Z, Kanevskiy L, Sapozhnikov A   +4 more
doaj  

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

FEBS Letters, Volume 599, Issue 23, Page 3524-3536, December 2025.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura, Lixiang Wang, Nao Hasuzawa, Ayako Nagayama, Sawako Moriyama, Kenji Ashida, Yoshinori Moriyama, Masatoshi Nomura, Ken Yamamoto   +8 more
wiley   +1 more source

Comportamento do sistema de aterramento de LDs 69 kV com estruturas de concreto sob descargas atmosféricas

Revista Principia, 2013
Este trabalho analisa o comportamento do sistema de aterramento de Linhas de Distribuição de 69kV com estruturas de concreto dotadas de cabo para-raios quando submetidas a descargas atmosféricas. Neste estudo, foram modelados com a utilização do software
Antonio dos Santos Dália, Franklin Martins Pamplona, José Tavares de Oliveira   +2 more
doaj   +1 more source

Reagentless Real‐Time ATP Monitoring with New DNA Aptamers

Small, Volume 21, Issue 48, December 3, 2025.
A new aptamer is discovered via in vitro selection that binds to adenosine triphosphate (ATP) with high affinity (KD = 0.7 µm) and rejects closely related analogs including adenosine diphosphate (ADP), adenosine monophosphate (AMP), and adenosine. A fluorescent molecular beacon based on the aptamer enables continuous analyte monitoring in cell culture ...
Adara Bacon, Obtin Alkhamis, Caleb Byrd, Jacob Perry, Juan Canoura, Yi Xiao   +5 more
wiley   +1 more source

Beneficial effects of PerformLyteTM, a prodosomed phytonutrient-enriched electrolyte formulation, in enhancing neuro-muscular synergy, immune competence, cellular aerobic glycolysis and sports performance [PDF]

BIO Web of Conferences
An optimised sports nutrition formulation achieving the correct blend of electrolytes with antioxidants and vitamins is integral towards meeting the demanding performance in professional sports arena.
William Downs Bernard, Banik Samudra P., Morrison Bruce S., Chakraborty Tandra, Bagchi Manashi, Chakraborty Sanjoy, Kushner Steve, Bagchi Debasis   +7 more
doaj   +1 more source

Mitochondrial Dysfunction Contributes to Decompensation in a Zebrafish Model of Isoproterenol‐Induced Heart Failure

Acta Physiologica, Volume 241, Issue 12, December 2025.
ABSTRACT Aim Heart failure is a clinical syndrome where the heart's structural or functional impairment leads to inadequate blood flow to meet the body's metabolic demands. Mitochondrial dysfunction is increasingly recognized as a central contributor underlying the contractile impairment observed in the failing heart.
Manuel Vicente, Aaron García‐Blázquez, Antonio Martínez‐Sielva, Jussep Salgado‐Almario, Joaquín Jordán, Beatriz Domingo, Juan Llopis   +6 more
wiley   +1 more source

Effect of Transcutaneous Acupoint Electrical Stimulation on Urinary Retention and Urinary ATP in Elderly Patients After Laparoscopic Cholecystectomy: A Prospective, Randomized, Controlled Clinical Trial

Clinical Interventions in Aging, 2022
Yanfang Zhang, Lirong Gong, Yuan Zhang, Shuan Dong, Jia Shi, Xiangyun Li, Yan Guo, Simeng He, Xiaoyang Wu, Shasha Liu, Huayang Liu, Lantian Zhang, Jianbo Yu Department of Anesthesiology and Critical Care Medicine, Tianjin Nankai Hospital, Tianjin Medical
Zhang Y, Gong L, Zhang Y, Dong S, Shi J, Li X, Guo Y, He S, Wu X, Liu S, Liu H, Zhang L, Yu J   +12 more
doaj  

ATP Hydrolysis by α‐Synuclein Amyloids is Mediated by Enclosing β‐Strand

Advanced Science, Volume 12, Issue 44, November 27, 2025.
Pathological amyloids have been considered chemically inert until recently. Here it is shown that α‐synuclein amyloids catalyze the hydrolysis of the universal energy molecule, ATP. The cryo‐EM structure of the complex reveals an additional β‐strand (purple) that encloses the ATP‐binding site. Within the cavity, several lysine residues are required for
Lukas Frey, Fiamma Ayelen Buratti, Istvan Horvath, Shraddha Parate, Ranjeet Kumar, Roland Riek, Pernilla Wittung‐Stafshede   +6 more
wiley   +1 more source

BIOREMEDIATION OF CADMIUM CONTAMINATED WATER: BACTERIAL ACCUMULATION AND SURFACE COMPLEXITY BY REVIBACILLUS AGRI C15 AND BREVIBACILLUS AGRI C15 CDR [PDF]

مجلة الأنبار للعلوم الزراعية
Brevibacillus agri C15 and Brevibacillus agri C15 CdR have been reported as a tool for do uptake of cadmium (Cd). Nevertheless, it is unclear whether these strains contrast in their adsorption behaviors and surface complexation could be one of the ...
N. M. T. Jebril, A. K. Murad, R. Boden
doaj   +1 more source