Results 51 to 60 of about 1,767,276 (258)

Reagentless Real‐Time ATP Monitoring with New DNA Aptamers

Small, EarlyView.
A new aptamer is discovered via in vitro selection that binds to adenosine triphosphate (ATP) with high affinity (KD = 0.7 µm) and rejects closely related analogs including adenosine diphosphate (ADP), adenosine monophosphate (AMP), and adenosine. A fluorescent molecular beacon based on the aptamer enables continuous analyte monitoring in cell culture ...
Adara Bacon, Obtin Alkhamis, Caleb Byrd, Jacob Perry, Juan Canoura, Yi Xiao   +5 more
wiley   +1 more source

Formoterol Acting via β2-Adrenoreceptor Restores Mitochondrial Dysfunction Caused by Parkinson’s Disease-Related UQCRC1 Mutation and Improves Mitochondrial Homeostasis Including Dynamic and Transport

Biology
Formoterol, a β2-adrenergic receptor (β2AR) agonist, shows promise in various diseases, but its effectiveness in Parkinson’s disease (PD) is debated, with unclear regulation of mitochondrial homeostasis.
Jui-Chih Chang, Huei-Shin Chang, Yi-Chun Chao, Ching-Shan Huang, Chin-Hsien Lin, Zhong-Sheng Wu, Hui-Ju Chang, Chin-San Liu, Chieh-Sen Chuang   +8 more
doaj   +1 more source

Targeting the Key Enzymes of Abnormal Fatty Acid β-oxidation as a Potential Strategy for Tumor Therapy

Frontiers in Bioscience-Landmark, 2022
Fatty acid metabolism has attracted extensive attention for its key role in the occurrence and development of tumors. Fatty acids not only participate in the biosynthesis of phospholipids in the membrane to overcome the demand for rapidly proliferating ...
Hongdan Chen, Zeyu Yang, Yiceng Sun, Supeng Yin, Mi Tang, Fan Zhang   +5 more
doaj   +1 more source

Madness, Medication--and Self-Induced Hallucination? Elleborus (and Woody Nightshade) in Anglo-Saxon England, 700-900 [PDF]

, 2013
This article studies what Anglo-Saxons in around 700--900 understood by the Latin plant-name elleborus, looking particularly at Aldhelm's Latin riddle Elleborus, which suggests that the word was understood to denote woody nightshade (Solanum dulcamara ...
Hall, ATP
core  

Coexpression of rat P2X2 and P2X6 subunits in Xenopus oocytes. [PDF]

, 2000
Transcripts for P2X(2) and P2X(6) subunits are present in rat CNS and frequently colocalize in the same brainstem nuclei. When rat P2X(2) (rP2X(2)) and rat P2X(6) (rP2X(6)) receptors were expressed individually in Xenopus oocytes and studied under ...
Burnstock, G, King, B F, Spyer, K M, Thomas, T, Townsend-Nicholson, A, Wildman, Scott S.P.   +5 more
core   +1 more source

Identification of an ATP-sensitive potassium channel in mitochondria

Nature, 2019
Mitochondria provide chemical energy for endoergonic reactions in the form of ATP, and their activity must meet cellular energy requirements, but the mechanisms that link organelle performance to ATP levels are poorly understood.
Angela Paggio, V. Checchetto, Antonio Campo, R. Menabò, Giulia Di Marco, F. Di Lisa, I. Szabó, R. Rizzuto, Diego De Stefani   +8 more
semanticscholar   +1 more source

P2X7 receptor antagonism suppresses epileptiform‐like activity in an inflammation‐primed human iPSC‐derived neuron model of drug‐resistant epilepsy

British Journal of Pharmacology, EarlyView.
Background and Purpose Neuroinflammation is increasingly recognised to contribute to drug‐resistant epilepsy. Activation of ATP‐gated P2X7 receptors has emerged as an important upstream mechanism, and increased P2X7 receptor expression is present in the seizure focus in rodent models and patients. Pharmacological antagonists of P2X7 receptors attenuate
Jaideep Kesavan, Yitao Wang, Klaus Dinkel, Michael Hamacher, Jochen H. M. Prehn, David C. Henshall, Tobias Engel   +6 more
wiley   +1 more source

Comportamento do sistema de aterramento de LDs 69 kV com estruturas de concreto sob descargas atmosféricas

Revista Principia, 2013
Este trabalho analisa o comportamento do sistema de aterramento de Linhas de Distribuição de 69kV com estruturas de concreto dotadas de cabo para-raios quando submetidas a descargas atmosféricas. Neste estudo, foram modelados com a utilização do software
Antonio dos Santos Dália, Franklin Martins Pamplona, José Tavares de Oliveira   +2 more
doaj   +1 more source

The OT\u27s Role in an Interprofessional Research Team [PDF]

, 2015
Why Interprofessional Research? The research field receives contributions from multiple disciplines and is inclusive by nature. •Feels natural in our day to day work practices to collaborate with other professions.
Benham, OTD, OTR/L, ATP, Sara, Toth-Cohen, PhD, OTR/L, Susan   +1 more
core   +1 more source

Structure, mechanism, and regulation of the chloroplast ATP synthase

Science, 2018
Protons find a path Adenosine triphosphate (ATP) synthases are dynamos that interconvert rotational and chemical energy. Capturing the complete structure of these multisubunit membrane-bound complexes has been hindered by their inherent ability to adopt ...
Alexander Hahn, J. Vonck, D. Mills, T. Meier, W. Kühlbrandt   +4 more
semanticscholar   +1 more source