Results 51 to 60 of about 1,728,775 (305)

The Role of Heat Shock Protein 70 kDa in Asthma

Journal of Asthma and Allergy, 2021
Marina Shevchenko,1 Ekaterina Servuli,1,2 Zarema Albakova,1,3 Leonid Kanevskiy,1 Alexander Sapozhnikov1,3 1Department of Immunology, Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia; 2Department of ...
Shevchenko M, Servuli E, Albakova Z, Kanevskiy L, Sapozhnikov A   +4 more
doaj  

Quercetin and histamine effects of the content of superoxide anion and ATP in the blood plasma of rats

Біологічні студії, 2023
Background. Histamine is one of the versatile biogenic amines with multiple roles in the immune response and allergic disorders. Histamine and ATP can act as ligands in the body.
Nataliya Harasym, Victoria Grondzal, Nataliia Bodnarchuk, Alina Zyn, Svitlana Mandzynets, Anastasiia Heneha   +5 more
doaj   +1 more source

The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP

Proceedings of the National Academy of Sciences of the United States of America, 2008
Lung cancers caused by activating mutations in the epidermal growth factor receptor (EGFR) are initially responsive to small molecule tyrosine kinase inhibitors (TKIs), but the efficacy of these agents is often limited because of the emergence of drug ...
C. Yun, Kristen E. Mengwasser, A. Toms, M. S. Woo, H. Greulich, Kwok-kin Wong, M. Meyerson, M. Eck   +7 more
semanticscholar   +1 more source

Structural Basis for the Catalytic Mechanism of ATP‐Dependent Diazotase CmaA6

Angewandte Chemie International Edition, EarlyView.
Several diazotases have been reported in recent years, but the detailed catalytic mechanism is unclear. From X‐ray crystallography and Cryo‐EM analysis, we obtained the structure of a diazotase CmaA6, which synthesizes 3‐diazocoumaric acid. Kinetic analysis and computational analysis indicated that CmaA6 catalyzes diazotization via an unprecedented ...
Seiji Kawai, Masayuki Karasawa, Yoshitaka Moriwaki, Tohru Terada, Yohei Katsuyama, Yasuo Ohnishi   +5 more
wiley   +1 more source

ATP synthesis and storage [PDF]

Purinergic Signalling, 2012
Since 1929, when it was discovered that ATP is a substrate for muscle contraction, the knowledge about this purine nucleotide has been greatly expanded. Many aspects of cell metabolism revolve around ATP production and consumption. It is important to understand the concepts of glucose and oxygen consumption in aerobic and anaerobic life and to link ...
Jan M. Suski, Jan M. Suski, Saverio Marchi, Paolo Pinton, Simone Patergnani, Angela Bononi, Carlotta Giorgi, Massimo Bonora, Elena De Marchi, Federica Poletti, Sonia Missiroli, Alessandro Rimessi, Mariusz R. Wieckowski   +12 more
openaire   +3 more sources

Non‐ionotropic NMDAR signalling activates Panx1 to induce P2X4R‐dependent long‐term depression in the hippocampus

The Journal of Physiology, EarlyView.
Abstract figure legend Stimulation of the Shaffer collateral pathway at 3 Hz activates non‐ionotropic NMDA receptors. This subsequently leads to Src kinase mediated phosphorylation of pannexin‐1 (Panx1), which releases ATP from the postsynaptic cell. ATP acts as a ligand for P2X4 receptors to induce long‐term depression (LTD). Abstract In recent years,
Allison C. Nielsen, Connor L. Anderson, Carina Ens, Andrew K. J. Boyce, Roger J. Thompson   +4 more
wiley   +1 more source

Formoterol Acting via β2-Adrenoreceptor Restores Mitochondrial Dysfunction Caused by Parkinson’s Disease-Related UQCRC1 Mutation and Improves Mitochondrial Homeostasis Including Dynamic and Transport

Biology
Formoterol, a β2-adrenergic receptor (β2AR) agonist, shows promise in various diseases, but its effectiveness in Parkinson’s disease (PD) is debated, with unclear regulation of mitochondrial homeostasis.
Jui-Chih Chang, Huei-Shin Chang, Yi-Chun Chao, Ching-Shan Huang, Chin-Hsien Lin, Zhong-Sheng Wu, Hui-Ju Chang, Chin-San Liu, Chieh-Sen Chuang   +8 more
doaj   +1 more source

Identification of an ATP-sensitive potassium channel in mitochondria

Nature, 2019
Mitochondria provide chemical energy for endoergonic reactions in the form of ATP, and their activity must meet cellular energy requirements, but the mechanisms that link organelle performance to ATP levels are poorly understood.
Angela Paggio, V. Checchetto, Antonio Campo, R. Menabò, Giulia Di Marco, F. Di Lisa, I. Szabó, R. Rizzuto, Diego De Stefani   +8 more
semanticscholar   +1 more source

Physiology and Robustness of Yeasts Exposed to Dynamic pH and Glucose Environments

Biotechnology and Bioengineering, Volume 122, Issue 7, Page 1656-1668, July 2025.
The authors investigated how three Saccharomyces cerevisiae strains respond to dynamic substrate and pH oscillations using dynamic microfluidic single‐cell cultivation (dMSCC) and intracellular biosensors. By combining performance and robustness analysis of selected intracellular parameters, growth and morphological analysis, the authors identified ...
Luca Torello Pianale, Luisa Blöbaum, Alexander Grünberger, Lisbeth Olsson   +3 more
wiley   +1 more source

The molecular mechanism of ATP synthesis by F1F0-ATP synthase

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2002
ATP synthesis by oxidative phosphorylation and photophosphorylation, catalyzed by F1F0-ATP synthase, is the fundamental means of cell energy production. Earlier mutagenesis studies had gone some way to describing the mechanism. More recently, several X-ray structures at atomic resolution have pictured the catalytic sites, and real-time video recordings
Alan E. Senior, Sashi Nadanaciva, Joachim Weber   +2 more
openaire   +3 more sources