Results 61 to 70 of about 26,623 (99)

Host Translational Control by Stress Granules Promotes Mycobacterium tuberculosis Pathogenesis

MedComm, Volume 6, Issue 11, November 2025.
During Mycobacterium tuberculosis infection, stress granules (SGs) formed in macrophages sequester key signaling and metabolic regulators such as mTORC1 components (mTOR, Raptor) and mitochondrial complex I subunits (Ndufa12), leading to suppressed cap‐dependent translation, reduced mitochondrial activity, and impaired innate immune responses.
Jaewhan Kim, Sang‐Hun Son, Ji‐Ae Choi, Junghwan Lee, Seoyeon Jo, Soo‐Na Cho, Doan Tam Nguyen, Doyi Son, Kee K. Kim, Chang‐Hwa Song   +9 more
wiley   +1 more source

The effectiveness of human SAGE medium compared to other conventional culture media on the ovine early embryonic development, in vitro [PDF]

Iraqi Journal of Veterinary Sciences
Developing an optimal in vitro embryo culture medium with high blastocyst rates and good-quality embryos remains challenging and controversial, as most culture media directly impact mammalian embryonic development.
Saif O. Al-Hafedh, Fatin Cedden, Ahmed O. Gatea   +2 more
doaj   +1 more source

Astrocytic Connexin43 Channels Are Essential for Breathing Pattern Stabilization in the preBötzinger Complex

CNS Neuroscience &Therapeutics, Volume 31, Issue 11, November 2025.
Both pharmacological blockade and genetic knockdown of astrocytic connexin43 channels in the preBötzinger complex induce a high‐frequency breathing pattern, thereby enhancing respiratory motor output. This effect is mediated by astrocytic activation and subsequent ATP release, which activates P2Y1 receptors on somatostatin‐expressing preBötzinger ...
Xue Zhao, Luo Shi, Yongqiang Chen, Hongxiao Yu, Xiaoyi Wang, Xinyi Jing, Tianjiao Deng, Ke Zhao, Xiang Zhang, Yixian Liu, Fang Yuan, Sheng Wang   +11 more
wiley   +1 more source

Fondová schémata jako možná řešení finanční udržitelnosti dánského penzijního systému

Trendy v podnikání, 2020
The financial sustainability of pension systems is one of the crucial topics in the context of population aging. The issue of financial sustainability is primarily associated with public unfunded pension schemes, where there is an increase in future ...
Jan Pokorný, Pavlína Hejduková
doaj   +1 more source

Neurobiology of mitochondrial dynamics in sleep

The Journal of Physiology, Volume 603, Issue 22, Page 6747-6762, November 15, 2025.
Abstract figure legend In neurons, variations in sleep history are accompanied by alterations in mitochondrial dynamics, including changes in size, fission and fusion events, the emergence of extra‐large and ‘hourglass’‐shaped mitochondria, mitophagy, and modifications in intracristal space volume and in the number of contact sites between mitochondria
Raffaele Sarnataro
wiley   +1 more source

Aberrant Mitochondrial Metabolism in Alzheimer's Disease Links Energy Stress with Ferroptosis

Advanced Science, Volume 12, Issue 37, October 6, 2025.
Alves et al. reveal how energy loss and oxidative stress, two major features of Alzheimer's disease, are connected. Mitochondria controls the flux of the antioxidant glutathione (GSH), via facilitating both its production and consumption. Energy restriction limits GSH synthesis, conferring vulnerability to cell death by ferroptosis, implicated as a ...
Francesca Alves, Darius Lane, Adam Wahida, Md. Jakaria, Pawel Kalinowski, Adam Southon, Abdel Ali Belaidi, Teresa Samperi‐Esteve, Triet Phu Minh Nguyen, Peng Lei, Marcus Krueger, Stefan Mueller, Marcus Conrad, Puja Agarwal, Sue E Leurgans, Julie Schneider, Ashley I. Bush, Scott Ayton   +17 more
wiley   +1 more source

Novel Anthraquinone Chlorination Contributes to Pigmentation and ATP Formation in Thermomyces dupontii

Microbial Biotechnology, Volume 18, Issue 10, October 2025.
This diagram illustrates the chlorination of anthraquinones and its biological functions in Thermomyces dupontii, elucidating how chlorination‐mediated fungal pigmentation promotes energy production and stress adaptation. (1) Extracellular Fenton Chemistry: Involves superoxide anion (O2−) and ferrous ion (Fe2+), which are two fundamental elements for ...
Donglou Wang, Gang Dai, Jiangbo He, Huiwen Si, Chunhua Liao, Wenjie Wang, Zhangxin Zuo, Shuhong Li, Xuemei Niu   +8 more
wiley   +1 more source

Técnica para identificar faltas transitorias y permanentes en líneas de transmisión, utilizando la transformada Wavelet

Revista Facultad de Ingeniería Universidad de Antioquia, 2009
En el presente documento, se presenta un algoritmo que permite distinguir de forma clara y precisa, las faltas transitorias de las permanentes. Adicionalmente se determina el instante de extinción del arco secundario, para así evitar o controlar de forma
Miguel Martínez
doaj  

Arabidopsis thaliana Cyclic Nucleotide‐Gated Channel 19 is involved in root extracellular ATP and Pep1 signalling

New Phytologist, Volume 248, Issue 5, Page 2192-2197, December 2025.
Youzheng Ning, Bryony C. I. C. Jacobs, Clementine Langlet, Limin Wang, Zhizhong Song, Adeeba M. Dark, Elsa Matthus, Sebastian Eves‐van den Akker, Taufiq Rahman, Julia M. Davies   +9 more
wiley   +1 more source

Cellular adenylate energy charge and adenine nucleotides in brain tissue during hypoglycemia in newly born BALB/c mice pups

Exploration of Medicine
Aim: Hypoglycemia occurs in the neonatal period but the exact pathophysiology of the resulting brain injury at the cellular level is not well known. Therefore, a neonatal murine model was developed with insulin-induced hypoglycemia, to analyze the in ...
Hassib Narchi, Priyadharshini Yuvaraju, Junu A. George, Richard L. Jayaraj, Radhakrishnan Subramanian   +4 more
doaj   +1 more source