Results 131 to 140 of about 40,880 (280)

Impaired ATP‐binding cassette transporter A1‐mediated sterol efflux from oxidized LDL‐loaded macrophages

FEBS Letters, 2005
We investigated the interaction of oxidized low density lipoprotein (OxLDL) with the ATP‐binding cassette A1 (ABCA1) pathway in J774 macrophages. Cellular efflux to apolipoprotein AI (apo‐AI) of OxLDL‐derived cholesterol was lower than efflux of cholesterol derived from acetylated low density lipoprotein (AcLDL).
FAVARI, Elda, ZIMETTI, Francesca, BORTNICK A. E., ADORNI, Maria Pia, ZANOTTI, Ilaria, CANAVESI M., BERNINI, Franco   +6 more
openaire   +3 more sources

Robust passive and active efflux of cellular cholesterol to a designer functional mimic of high density lipoprotein

Journal of Lipid Research, 2015
The ability of HDL to support macrophage cholesterol efflux is an integral part of its atheroprotective action. Augmenting this ability, especially when HDL cholesterol efflux capacity from macrophages is poor, represents a promising therapeutic strategy.
Andrea J. Luthi, Nicholas N. Lyssenko, Duyen Quach, Kaylin M. McMahon, John S. Millar, Kasey C. Vickers, Daniel J. Rader, Michael C. Phillips, Chad A. Mirkin, C.Shad Thaxton   +9 more
doaj   +1 more source

Lonicera caerulea Berry Polyphenols Regulate Cholesterol Metabolism in Rats With Type 2 Diabetes by Activating SIRT1 Expression in Macrophages and Reducing Foaming

Food Frontiers, Volume 7, Issue 1, January 2026.
1. Dietary LCBP supplementation in T2DM rats can improve abnormal cholesterol metabolism. 2. LCBP inhibits the formation of foam cells of macrophages of T2DM rats. 3. LCBP activated SIRT1 by enhanced the regulation of miR‐33/SREBP2 and ABCA1, but this effect was not dependent on SIRT1. 4.
Suwen Liu, Wenhong Jiang, Hanchen Li, Xuli Wang, Jiancheng Ma, Lina Dong   +5 more
wiley   +1 more source

Prion infection impairs cholesterol metabolism in neuronal cells [PDF]

, 2013
Conversion of prion protein (PrPC) into a pathological isoform (PrPSc) during prion infection occurs in lipid rafts and is dependent on cholesterol.
Bukrinsky, Michael I., Coleman, Bradley M., Cui, Huanhuan L., Ellett, Laura, Guo, Belinda, Hill, Andrew F., Lawson, Victoria A., Meikle, Peter J., Mukhamedova, Nigora, Scicluna, Benjamin, Sviridov, Dmitri   +10 more
core   +3 more sources

Lactobacillus plantarum CUL66 can impact cholesterol homeostasis in Caco-2 enterocytes [PDF]

, 2016
Hypercholesterolemia drives the development of cardiovascular disease, the leading cause of mortality in western society. Supplementation with probiotics that interfere with cholesterol metabolism may provide a contribution to disease prevention ...
Calvente, D. Lama, Garaiova, I., Michael, D. R., Moss, Joe W. E., Plummer, S. F., Ramji, Dipak   +5 more
core   +1 more source

A high cholesterol diet accelerates Alzheimer's progression by promoting fibrotic damage in rats

Brain Disorders
The literature documents the ability of oxysterols and TGFβ to cause fibrotic damage in the brain. Our study explores the potential mechanisms of oxysterol interactions with fibrotic mediators in Alzheimer's disease.
Ashmita Das, Durlav Chowdhury, Dilip Sharma, Rahul Manna, Surendra H. Bodakhe   +4 more
doaj   +1 more source

PXR induces CYP27A1 and regulates cholesterol metabolism in the intestine

Journal of Lipid Research, 2007
Mitochondrial sterol 27-hydroxylase (CYP27A1) catalyzes oxidative cleavage of the sterol side chain in the bile acid biosynthetic pathway in the liver and 27-hydroxylation of cholesterol in most tissues. Recent studies suggest that 27-hydroxycholesterol (
Tiangang Li, Wenling Chen, John Y.L. Chiang   +2 more
doaj   +1 more source

Ceramide Enhances Cholesterol Efflux to Apolipoprotein A-I by Increasing the Cell Surface Presence of ATP-binding Cassette Transporter A1*

Journal of Biological Chemistry, 2003
It is widely accepted that functional ATP-binding cassette transporter A1 (ABCA1) is critical for the formation of nascent high density lipoprotein particles.
S. Witting, J. N. Maiorano, W. Davidson
semanticscholar   +1 more source

Different cellular traffic of LDL-cholesterol and acetylated LDL-cholesterol leads to distinct reverse cholesterol transport pathwayss⃞

Journal of Lipid Research, 2007
Endocytosis of LDL and modified LDL represents regulated and unregulated cholesterol delivery to macrophages. To elucidate the mechanisms of cellular cholesterol transport and egress under both conditions, various primary macrophages were labeled and ...
Ming-Dong Wang, Robert S. Kiss, Vivian Franklin, Heidi M. McBride, Stewart C. Whitman, Yves L. Marcel   +5 more
doaj   +1 more source

Diversification and expression of the PIN, AUX/LAX, and ABCB families of putative auxin transporters in \u3cem\u3ePopulus\u3c/em\u3e [PDF]

, 2012
Intercellular transport of the plant hormone auxin is mediated by three families of membrane-bound protein carriers, with the PIN and ABCB families coding primarily for efflux proteins and the AUX/LAX family coding for influx proteins. In the last decade
Carraro, Nicola, Clouse, Ronald Matthew, Knöller, Anne Sophie, Spicer, Rachel, Tisdale-Orr, Tracy Elizabeth   +4 more
core   +1 more source