Negative-feedback regulation of ATP release: ATP release from cardiomyocytes is strictly regulated during ischemia [PDF]
Biochemical and Biophysical Research Communications, 2011 Extracellular ATP acts as a potent agonist on cardiomyocytes, inducing a broad range of physiological responses via P2 purinoceptors. Its concentration in the interstitial space within the heart is elevated during ischemia or hypoxia due to its release from a number of cell types, including cardiomyocytes.
Kunugi, Satohiko +4 more
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Microglial migration mediated by ATP-induced ATP release from lysosomes [PDF]
Cell Research, 2012 Microglia are highly motile cells that act as the main form of active immune defense in the central nervous system. Attracted by factors released from damaged cells, microglia are recruited towards the damaged or infected site, where they are involved in degenerative and regenerative responses and phagocytotic clearance of cell debris. ATP release from
Ying, Dou +10 more
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Sphingosine 1-phosphate is released from the cytosol of rat platelets in a carrier-mediated manner
Journal of Lipid Research, 2006 Sphingosine 1-phosphate (S1P) is accumulated in platelets and released on stimulation by thrombin or Ca2+. Thrombin-stimulated S1P release was inhibited by staurosporin, whereas Ca2+-stimulated release was not.
Nobuyoshi Kobayashi +6 more
doaj +1 more source
Renal epithelial cells can release ATP by vesicular fusion
Frontiers in Physiology, 2013 Renal epithelial cells have the ability to release nucleotides as paracrine factors. In the intercalated cells of the collecting duct, ATP is released by connexin30 (cx30), which is selectively expressed in this cell type.
Randi G Bjaelde +4 more
doaj +1 more source
Purinergic responses of chondrogenic stem cells to dynamic loading [PDF]
Journal of the Serbian Chemical Society, 2013 In habitually loaded tissues, dynamic loading can trigger ATP (adenosine 5’- triphosphate) release to extracellular environment, and result in calcium signaling via ATP binding to purine P2 receptors1.
Gađanski Ivana +1 more
doaj +1 more source
New platelet functional method for identification of pathogenic antibodies in HIT patients
Platelets, 2017 Heparin-induced thrombocytopenia (HIT) is a thrombotic complication of heparin therapy. The most used functional method for HIT diagnosis is serotonin release assay (SRA).
M. L. Guarino +6 more
doaj +1 more source
Altered ATP release and metabolism in dorsal root ganglia of neuropathic rats
Molecular Pain, 2008 Background Adenosine 5'-triphosphate (ATP) has a ubiquitous role in metabolism and a major role in pain responses after tissue injury. We investigated the changes in basal and KCl-evoked ATP release from rat dorsal root ganglia (DRG) after peripheral ...
Omoto Kevin S +8 more
doaj +1 more source
CO2-Induced ATP-Dependent Release of Acetylcholine on the Ventral Surface of the Medulla Oblongata. [PDF]
PLoS ONE, 2016 Complex mechanisms that detect changes in brainstem parenchymal PCO2/[H+] and trigger adaptive changes in lung ventilation are responsible for central respiratory CO2 chemosensitivity.
Robert T R Huckstepp +2 more
doaj +1 more source
Mechanisms of ATP Release by Inflammatory Cells [PDF]
International Journal of Molecular Sciences, 2018 Extracellular nucleotides (e.g., ATP, ADP, UTP, UDP) released by inflammatory cells interact with specific purinergic P2 type receptors to modulate their recruitment and activation. The focus of this review is on stimuli and mechanisms of extracellular nucleotide release and its consequences during inflammation.
Michel Dosch +3 more
openaire +3 more sources
ATP Release from Human Airway Epithelial Cells Exposed to Staphylococcus aureus Alpha-Toxin
Toxins, 2016 Airway epithelial cells reduce cytosolic ATP content in response to treatment with S. aureus alpha-toxin (hemolysin A, Hla). This study was undertaken to investigate whether this is due to attenuated ATP generation or to release of ATP from the cytosol ...
Romina Baaske +6 more
doaj +1 more source