Results 31 to 40 of about 837,065 (393)
mBio, 2023 Coiled-coil-helix-coiled-coil-helix (CHCH) domains consist of two pairs of cysteine residues that are oxidized to form disulfide bonds upon mitochondrial import.
Madelaine M. Usey, Diego Huet
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Reversible Thiol Oxidation Inhibits the Mitochondrial ATP Synthase in Xenopus Laevis Oocytes
Antioxidants, 2020 Oocytes are postulated to repress the proton pumps (e.g., complex IV) and ATP synthase to safeguard mitochondrial DNA homoplasmy by curtailing superoxide production. Whether the ATP synthase is inhibited is, however, unknown.
James Cobley +4 more
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Quick guide: ATP synthase [PDF]
Current Biology, 2001 Also known as… F1Fo ATP synthase, F1Fo ATPase, F-type ATPase. F1 denotes the soluble catalytic headgroup where ATP synthesis and hydrolysis occur, and Fo is the ion-translocating membrane domain (see Fig. 1Fig. 1).Fig. 1An illustration of the E. coli F1Fo. F1 is made up of five different subunits, with a stoichiometry α3β3γδe, and the composition of Fo
Ignacio Arechaga, Phil C. Jones
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Structure of the dimeric ATP synthase from bovine mitochondria
Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance Adenosine triphosphate (ATP), the fuel of life, is produced in inner membranes of the mitochondria of eukaryotic cells by an embedded molecular machine with a rotary action, called ATP synthase. Single ATP synthases associate into dimers and
T. Spikes, M. G. Montgomery, J. Walker
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ATP Synthase and Mitochondrial Bioenergetics Dysfunction in Alzheimer’s Disease
International Journal of Molecular Sciences, 2021 Alzheimer’s Disease (AD) is the most common neurodegenerative disorder in our society, as the population ages, its incidence is expected to increase in the coming decades.
S. Patro +8 more
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Assembling the mitochondrial ATP synthase [PDF]
Proceedings of the National Academy of Sciences, 2018 Mitochondria are known as the powerhouses of the cell. The F1Fo-ATP synthase of the mitochondrial inner membrane produces the bulk of cellular ATP. The respiratory chain complexes pump protons across the inner membrane into the intermembrane space and thereby generate a proton-motive force that drives the ATP synthase.
Jiyao Song +2 more
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Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance Mitochondria are the powerhouses of eukaryotic cells. Pairs of molecular machines with a rotary action, called ATP synthase, are embedded in their inner membranes and produce adenosine triphosphate, ATP, the fuel of life.
T. Spikes, M. G. Montgomery, J. Walker
semanticscholar +1 more source
Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1998 A model is presented in which ion translocation through the F0 part of the ATP synthase drives the rotation of the ring of c subunits (rotor) versus the a subunit (stator). The coupling ion binding sites on the rotor are accessible from the cytoplasm of a bacterial cell except for the c subunit at the interface to the stator.
Peter Dimroth +2 more
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A new type of Na+-driven ATP synthase membrane rotor with a two-carboxylate ion-coupling motif [PDF]
, 2013 : The anaerobic bacterium Fusobacterium nucleatum uses glutamate decarboxylation to generate a transmembrane gradient of Na+. Here, we demonstrate that this ion-motive force is directly coupled to ATP synthesis, via an F1Fo-ATP synthase with a novel Na ...
Faraldo-Gómez, José D. +8 more
core +3 more sources
Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance As the world tackles the COVID-19 pandemic, other widespread infectious diseases, including tuberculosis (TB), take their toll on humans, and those with TB are more likely to die from COVID-19 infection.
M. G. Montgomery +3 more
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