Results 81 to 90 of about 33,070 (201)

CXC Chemokine‐Driven Vascular Reprogramming: Modulating Tumor Vasculature to Boost Therapeutic Response

Advanced Science, EarlyView.
Tumor vascular remodeling is discussed from a chemokine‐centered perspective. This review summarizes the bidirectional, temporal, and tissue‐specific roles of CXC chemokines in regulating vascular function and immune accessibility. A functional vascular normalization score is introduced as a conceptual framework to integrate dynamic vascular and immune
Hongdan Chen, Yinde Huang, Juntong Wu, Ziying Yi, Yao Li, Zeyu Yang, Fan Zhang, Chong Li   +7 more
wiley   +1 more source

Chemotactic Cues for NOTCH1-Dependent Leukemia [PDF]

, 2018
The NOTCH signaling pathway is a conserved signaling cascade that regulates many aspects of development and homeostasis in multiple organ systems.
Amadori, Alberto, Piovan, Erich, Tosello, Valeria, Zanovello, Paola   +3 more
core   +1 more source

ACKR2 in hematopoietic precursors as a checkpoint of neutrophil release and anti-metastatic activity

Nature Communications, 2018
The atypical chemokine receptor ACKR2 regulates immune responses. Here the authors confirm that ACKR2 depletion promotes primary tumor growth but show it has an anti-metastatic effect in mouse models of breast cancer by affecting myeloid differentiation ...
Matteo Massara, Ornella Bonavita, Benedetta Savino, Nicoletta Caronni, Valeria Mollica Poeta, Marina Sironi, Elisa Setten, Camilla Recordati, Laura Crisafulli, Francesca Ficara, Alberto Mantovani, Massimo Locati, Raffaella Bonecchi   +12 more
doaj   +1 more source

Sjögren Disease—B Cells at the Brink: From Autoimmunity to Lymphomagenesis and the Rise of Novel B Cell–Targeted Therapies

Arthritis &Rheumatology, EarlyView.
Sjögren disease (SjD) is a common systemic autoimmune disorder characterized by inflammation of the exocrine glands, resulting in dryness. Patients frequently exhibit extraglandular manifestations affecting various organ systems. To date, there are no US Food and Drug Administration (FDA)‐approved disease‐modifying therapies for SjD. In this review, we
Rachael A. Gordon, Sara S. McCoy
wiley   +1 more source

CXCL14 Preferentially Synergizes With Homeostatic Chemokine Receptor Systems

Frontiers in Immunology, 2020
Reflecting their importance in immunity, the activity of chemokines is regulated on several levels, including tissue and context-specific expression and availability of their cognate receptor on target cells. Chemokine synergism, affecting both chemokine
Ariadni Kouzeli, Paul J. Collins, Mieke Metzemaekers, Max Meyrath, Martyna Szpakowska, Marc Artinger, Sofie Struyf, Paul Proost, Andy Chevigne, Daniel F. Legler, Matthias Eberl, Bernhard Moser   +11 more
doaj   +1 more source

Cross-genetic determination of maternal and neonatal immune mediators during pregnancy. [PDF]

, 2018
BACKGROUND:The immune system plays a fundamental role in development during pregnancy and early life. Alterations in circulating maternal and neonatal immune mediators have been associated with pregnancy complications as well as susceptibility to ...
Ashwood, Paul, Croen, Lisa A, DeLorenze, Gerald N, Heuer, Luke S, Jones, Karen L, Kharrazi, Martin, Traglia, Michela, Van de Water, Judy, Weiss, Lauren A, Yolken, Robert   +9 more
core  

Concepts of GPCR-controlled navigation in the immune system

, 2019
G-protein-coupled receptor (GPCR) signaling is essential for the spatiotemporal control of leukocyte dynamics during immune responses. For efficient navigation through mammalian tissues, most leukocyte types express more than one GPCR on their surface ...
Boneschansker L, Brandt SL, Chan EC, Filippo K, Freedman NJ, Hjorto GM, Hons M, Katakai T, Kitayama J, Lemos C, Ley K, Miyabe Y, Moussavi‐Harami SF, Proudfoot AEI, Purvanov V, Rot A, Scheiermann C, Schwarz J, Sokol CL, Sotsios Y, Steury MD, Takeda A, Thiriot A, Tomhave ED, Wang Y, Yanagihara S, Zhang Y   +26 more
core   +1 more source

Chemokine Receptors and Phagocyte Biology in Zebrafish

Frontiers in Immunology, 2020
Phagocytes are highly motile immune cells that ingest and clear microbial invaders, harmful substances, and dying cells. Their function is critically dependent on the expression of chemokine receptors, a class of G-protein-coupled receptors (GPCRs ...
Frida Sommer, Vincenzo Torraca, Annemarie H. Meijer   +2 more
doaj   +1 more source

Harnessing Natural Compounds in Psoriasis: Targeting Cellular Pathways for Effective Therapy

Phytotherapy Research, EarlyView.
Natural compounds act on key cellular pathways in psoriasis by suppressing keratinocyte hyperproliferation, modulating Th17/IL‐17‐mediated immune responses, and reducing oxidative stress. These multi‐target effects highlight their potential as safer adjunctive therapies alongside conventional treatments.
Hye Jin Lee, Yu Jin So, Il‐Joo Jo, Ji Yong Jang, Tae Han Yook, Jun Ho Lee, Sung Wook Kim, Kangwook Lee, Soo Jung Park, Gabsik Yang   +9 more
wiley   +1 more source

Functional characterization of a short peptidoglycan recognition protein from Chinese giant salamander (Andrias davidianus) [PDF]

, 2017
This work was supported by the National Natural Science Foundation of China (Grant no. 31302221, 31172408 and 31272666) and Jiangsu Province (Grant no.
Chang, Mingxian, Nie, Pin, Qi, Zhitao, Qiao, Guo, Ren, Shisi, Wang, Zisheng, Xu, Qiaoqing, Zhang, Qihuan, Zou, Jun   +8 more
core   +1 more source