Results 121 to 130 of about 28,527 (253)

Autoimmunity and Periodontitis

Journal of Periodontal Research, EarlyView.
In a microbe‐driven inflammatory environment, peptidyl‐arginine deiminase (PAD) enzymes from neutrophils and Porphyromonas gingivalis citrullinate both microbial and self‐antigens. B cell presentation of citrullinated or self‐mimicking epitopes activates T cells that assist B cells in antibody isotype switching, affinity maturation, epitope spreading ...
Massimo Costalonga, Vivek Thumbigere‐Math, Mark C. Herzberg   +2 more
wiley   +1 more source

Atypical chemokine receptor CCRL2 is overexpressed in prostate cancer cells

The Journal of Biomedical Research, 2019
Atypical chemokine receptors have recently emerged as important molecular players in health and diseases; they affect chemokine availability and function and impact a multitude of pathophysiological events, including the tumorigenesis process. This family of atypical receptors comprises five members: ACKR1/DARC, ACKR2/D6, ACKR3/CXCR7, ACKR4/CCRL1, and ...
Reyes, Niradiz, Benedetti, Ines, Rebollo, Juan, Correa, Oscar, Geliebter, Jan   +4 more
openaire   +2 more sources

The Atypical Receptor CCRL2 (C-C Chemokine Receptor-Like 2) Does Not Act As a Decoy Receptor in Endothelial Cells

Frontiers in Immunology, 2017
C-C chemokine receptor-like 2 (CCRL2) is a non-signaling seven-transmembrane domain (7-TMD) receptor related to the atypical chemokine receptor (ACKR) family.
Chiara Mazzotti, Vincenzo Gagliostro, Daniela Bosisio, Annalisa Del Prete, Annalisa Del Prete, Laura Tiberio, Marcus Thelen, Silvano Sozzani, Silvano Sozzani   +8 more
doaj   +1 more source

Adjunctive Therapies in Periodontitis: Current Concepts and the Future

Journal of Periodontal Research, EarlyView.
This graphical abstract summarizes the translational pathway from preclinical research to clinical implementation of adjunctive therapies for periodontitis, highlighting key barriers, innovative therapeutic strategies, and emerging tools that aim to bridge experimental discoveries with patient care.
Rafael Scaf de Molon, Joao Paulo Steffens, Erica Dorigatti de Avila, Wim Teughels, Thomas E. Van Dyke   +4 more
wiley   +1 more source

Association Between Oral Lichen Planus and Non‐Oral Cancers: A Multicentre Case–Control SIPMO Study

Oral Diseases, EarlyView.
ABSTRACT Objectives This multicentre case–control study aimed to investigate the potential association between oral lichen planus (OLP) and extraoral cancers. The secondary objective included the identification of risk factors for this association. Methods The study was conducted between January 2023 and June 2024 and included 21 Italian Oral Medicine ...
Gioele Gioco, Anna Schiavelli, Alessandra Majorana, Elena Bardellini, Silvio Abati, Andrea Sardella, Francesco Spadari, Matteo Pellegrini, Dorina Lauritano, Raffaele Borgia, Monica Pentenero, Samuele Sutera, Paolo Giacomo Arduino, Alessio Gambino, Roberto Broccoletti, Matteo Biasotto, Giulia Ottaviani, Lorenzo Azzi, Alessandro D'Aiuto, Davide Bartolomeo Gissi, Andrea Gabusi, Andrea Santarelli, Marco Mascitti, Paolo Vescovi, Gloria Bortolotti, Maddalena Manfredi, Marco Meleti, Grazia Zino, Umberto Romeo, Gianluca Tenore, Gianfranco Favia, Luisa Limongelli, Massimo Petruzzi, Francesca Dimilito, Lorenzo Lo Muzio, Maria Eleonora Bizzoca, Giuseppina Campisi, Vera Panzarella, Stefania Leuci, Rosario Serpico, Alberta Lucchese, Giuseppe Colella, Giacomo Oteri, Antonia Marcianò, Gaetano Isola, Alessandro Polizzi, Amerigo Giudice, Elena Calabria, Umberto Mariani, Daniela Adamo, Federica Canfora, Filippo Graziani, Marco Nisi, Michele Giuliani, Luisa Ritrovato, Federica De Micheli, Cosimo Rupe, Francesco Scilla, Romeo Patini, Massimo Cordaro, Michele Davide Mignogna, Carlo Lajolo, SIPMO (Italian Society of Oral Pathology and Medicine)   +62 more
wiley   +1 more source

Expression of the chemokine decoy receptor D6 mediates dendritic cell function and promotes corneal allograft rejection [PDF]

, 2014
Purpose To identify the role of chemokine receptor 6 (D6) expression by dendritic cells (DCs) and its role in corneal transplant immunity. Methods: Flow cytometry analysis was used to assess the expression level of the D6 chemokine receptor in different ...
Chauhan, Sunil K., Dana, Reza, Hajrasouliha, Amir R., Lee, Hyung K., Sadrai, Zahra   +4 more
core  

Heparan Sulfate: A Ubiquitous Glycosaminoglycan with Multiple Roles in Immunity

, 2015
Heparan sulfate (HS) is a highly acidic linear polysaccharide with a very variable structure. It is ubiquitously expressed on cell surfaces and in the extracellular matrix and basement membrane of mammalian tissues.
Parish, Christopher, Simon Davis, David Anak   +1 more
core   +1 more source

Immune modulation by virus-encoded secreted chemokine binding proteins [PDF]

, 2015
Chemokines are chemoattractant cytokines that mediate the migration of immune cells to sites of infection which play an important role in innate and adaptive immunity. As an immune evasion strategy, large DNA viruses (herpesviruses and poxviruses) encode
Alcamí, Antonio, Heidarieh, Haleh, Hernáez, Bruno   +2 more
core   +1 more source

The role of acquired host immunity in periodontal diseases

Periodontology 2000, EarlyView.
Abstract The aim of this narrative review is to relate the contribution of European researchers to the complex topic of the host immune system in periodontal disease, focusing on acquired immunity. Other chapters in this volume will address the genetics and autoantibody responses and other forms of immunity to periodontal disease.
Denis F. Kinane, David F. Lappin, Shauna Culshaw   +2 more
wiley   +1 more source

RIPK3 restricts viral pathogenesis via cell death-independent neuroinflammation [PDF]

, 2017
Receptor-interacting protein kinase-3 (RIPK3) is an activator of necroptotic cell death, but recent work has implicated additional roles for RIPK3 in inflammatory signaling independent of cell death.
Daniels, Brian P., Gale, Michael, Loo, Yueh-Ming, Martinez, Jennifer, Oberst, Andrew, Oguin III, Thomas H., Olsen, Tayla M., Orozco, Susana, Snyder, Annelise G., Tait, Stephen W.G.   +9 more
core   +1 more source