Correction to “International Union of Pharmacology. LXXXIX. Update on the Extended Family of Chemokine Receptors and Introducing a New Nomenclature for Atypical Chemokine Receptors” [PDF]
Pharmacol Rev, 2014 Graham Gj, Sparre-Ulrich Ah, Murphy Pm
europepmc +3 more sources
Frontiers in Immunology, 2023 Atypical chemokine receptors (ACKRs) form a small subfamily of receptors (ACKR1–4) unable to trigger G protein-dependent signaling in response to their ligands.
Martyna Szpakowska +10 more
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Structural basis of ligand interaction with atypical chemokine receptor 3 [PDF]
Nature Communications, 2017 AbstractChemokines drive cell migration through their interactions with seven-transmembrane (7TM) chemokine receptors on cell surfaces. The atypical chemokine receptor 3 (ACKR3) binds chemokines CXCL11 and CXCL12 and signals exclusively through β-arrestin-mediated pathways, without activating canonical G-protein signalling. This receptor is upregulated
Martin Gustavsson +10 more
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Prospects for targeting ACKR1 in cancer and other diseases
Frontiers in Immunology, 2023 The chemokine network is comprised of a family of signal proteins that encode messages for cells displaying chemokine G-protein coupled receptors (GPCRs).
Kyler S. Crawford, Brian F. Volkman
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Emerging Roles of the Atypical Chemokine Receptor 3 (ACKR3) in Cardiovascular Diseases
Frontiers in Endocrinology, 2022 Chemokines, and their receptors play a crucial role in the pathophysiology of cardiovascular diseases (CVD). Chemokines classically mediate their effects by binding to G-protein-coupled receptors.
Vincent Duval +4 more
doaj +1 more source
Atypical chemokine receptor 1 on nucleated erythroid cells regulates hematopoiesis [PDF]
Nature Immunology, 2017 Healthy individuals of African ancestry have neutropenia that has been linked with the variant rs2814778(G) of the gene encoding atypical chemokine receptor 1 (ACKR1). This polymorphism selectively abolishes the expression of ACKR1 in erythroid cells, causing a Duffy-negative phenotype.
Johan Duchêne +17 more
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Phosphoproteomic mapping of CCR5 and ACKR2 signaling properties
Frontiers in Molecular Biosciences, 2022 ACKR2 is an atypical chemokine receptor which is structurally uncoupled from G proteins and is unable to activate signaling pathways used by conventional chemokine receptors to promote cell migration.
Alessandro Vacchini +16 more
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Atypical Chemokine Receptors in Renal Inflammation [PDF]
Nephron Experimental Nephrology, 2010 Chemokines are structurally related proteins which form a large family of chemotactic cytokines. They provide a general communication system for cells and regulate lymphocyte migration. These proteins orchestrate the formation of microenvironments in lymphoid tissue, promote lymphoid organogenesis and help foster vascular and lymphatic angiogenesis. In
Segerer, S, Jedlicka, J, Wüthrich, R P
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Beyond Cell Motility: The Expanding Roles of Chemokines and Their Receptors in Malignancy
Frontiers in Immunology, 2020 The anti-tumor activities of some members of the chemokine family are often overcome by the functions of many chemokines that are strongly and causatively linked with increased tumor progression.
Dina Morein +2 more
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Role of Atypical Chemokines and Chemokine Receptors Pathways in the Pathogenesis of COPD [PDF]
Current Medicinal Chemistry, 2021 Chronic obstructive pulmonary disease (COPD) represents a heightened inflammatory response in the lung generally resulting from tobacco smoking-induced recruitment and activation of inflammatory cells and/or activation of lower airway structural cells.
Francesco Nucera +10 more
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