Results 21 to 30 of about 24,341 (292)

Eculizumab for Atypical Hemolytic–Uremic Syndrome [PDF]

New England Journal of Medicine, 2009
To the Editor: Atypical hemolytic–uremic syndrome is a disease of uncontrolled complement activation associated with a high mortality rate, and most cases progress to end-stage renal disease.1 About 50% of patients with this syndrome carry mutations in genes encoding complement proteins.2 Complement inhibition has been suggested for the treatment of ...
Michael Kirschfink, Oliver Witzke, Jens Nürnberger, Andreas Kribben, Mato Nagel, Hideo A. Baba, Anabelle Opazo Saez, Andreas R. Janecke, Lothar Bernd Zimmerhackl, Thomas Philipp, Udo Vester   +10 more
openalex   +3 more sources

Atypical hemolytic uremic syndrome [PDF]

Hematology, 2016
AbstractAtypical hemolytic uremic syndrome (aHUS) is a thrombotic microangiopathy (TMA) that affects multiple organs and the kidneys in particular. aHUS can be sporadic or familial and is most commonly caused by dysregulation of the alternative complement pathway.
Arif Asif, Ali Nayer
openaire   +6 more sources

Atypical Hemolytic-Uremic Syndrome: Genetic Basis, Clinical Manifestations, and a Multidisciplinary Approach to Management

Journal of Multidisciplinary Healthcare, 2023
Hemolytic uremic syndrome (HUS) is a thrombotic microangiopathy (TMA) defined by the triad of hemolytic anemia, thrombocytopenia, and acute kidney injury.
Keval Yerigeri, S. Kadatane, Kai Mongan, Olivia Boyer, Linda Burke, S. Sethi, Christoph Licht, R. Raina   +7 more
semanticscholar   +1 more source

Hemolytic Uremic Syndrome: A Case Report

Journal of Nepal Medical Association, 2023
Thrombotic microangiopathy is a pathological condition comprised of microvascular thrombosis involving any body organ leading to thrombocytopenia, coombs-negative hemolytic anemia, and end-organ damage.
Sandesh Gaire, Mandira Shrestha, Chaitanya Darshan Bhattarai, Susajjan Dhungana, Surakshya Gyawali, Arun Bajgain   +5 more
doaj   +1 more source

CFH and CFHR structural variants in atypical Hemolytic Uremic Syndrome: Prevalence, genomic characterization and impact on outcome

Frontiers in Immunology, 2023
Introduction Atypical hemolytic uremic syndrome (aHUS) is a rare disease that manifests with microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure, and is associated with dysregulation of the alternative complement pathway.
R. Piras, E. Valoti, M. Alberti, E. Bresin, C. Mele, M. Breno, L. Liguori, R. Donadelli, M. Rigoldi, A. Benigni, G. Remuzzi, M. Noris   +11 more
semanticscholar   +1 more source

Atypical Hemolytic Uremic Syndrome [PDF]

Seminars in Nephrology, 2013
Hemolytic uremic syndrome (HUS) is a triad of microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure. The atypical form of HUS is a disease characterized by complement overactivation. Inherited defects in complement genes and acquired autoantibodies against complement regulatory proteins have been described.
Kavanagh D, Goodship TH, Richards A
openaire   +4 more sources

Case series: coronavirus disease 2019 infection as a precipitant of atypical hemolytic uremic syndrome: two case reports

Journal of Medical Case Reports, 2021
Background Atypical hemolytic uremic syndrome is an exceedingly rare thrombotic microangiopathy caused by accelerated activation of the alternative complement pathway.
Christine J. Kurian, Zachary French, Patrick Kukulich, Matthew Lankiewicz, Sushil Ghimire, Omar H. Maarouf, Sanaa Rizk, Ruben Rhoades   +7 more
doaj   +1 more source

Atypical hemolytic uremic syndrome in the era of terminal complement inhibition: an observational cohort study

Blood, 2023
Key Points • We prove in genotype-matched complement-mediated aHUS cohorts that C5 inhibition results in a statistical improvement in ESKD-free survival.• We demonstrate that biallelic pathogenic mutations in EXOSC3 cause eculizumab nonresponsive aHUS.
V. Brocklebank, Patrick R. Walsh, K. Smith-Jackson, T. Hallam, K. Marchbank, V. Wilson, Theophile Bigirumurame, T. Dutt, Emma K Montgomery, M. Malina, Edwin K.S. Wong, Sally Johnson, N. Sheerin, D. Kavanagh, Richard Caroline Neil Stanley Suzanne Ravindra Declan Colm Holt Jones Ashman Fan Forbes Rajakariar De Freitas, Richard Holt, Caroline Jones, Neil Ashman, Stanley Fan, Suzanne Forbes, R. Rajakariar, Declan de Freitas, Colm Magee, Jennifer Hanko, David Milford, M. Muorah, Alexander J. Howie, Jyoti Baharani, Indranil Dasgupta, Russell Roberts, Adam MacDiarmaid-Gordon, Andrew Fry, Nicholas Torpey, Mary Waldron, Atif Awan, Tara Raftery, Laura Ratcliffe, Enric Vilar, Joel Newman, Dale Seviar, Stephen D. Marks, Lesley Rees, Faidra Veligratli, Aoife Waters, Paramit Chowdhury, James Pattison, Caroline Booth, Nicole Williams, Richard Corbett, Beena Amin, Matthew Pickering, Kate Bramham, Mohamed Al-Hamed, Anita Hill, Andrew Mooney, Eric Finlay, Amanda Newnham, Pallavi Yadav, Amrit Kaur, Nicholas Plant, Mohan Shenoy, Lye Wai Choong, A. Helps, Robert McLemon, Thalakunte M Muniraju, Izhar Khan, Dana Kidder, Neal Padmanabhan, Zoe Cousland, Jonathan Price, Alison Taylor, Claudine Jennings, Sohail Ahmad, Paul Mead, Mona Aslam, Charlotte Bebb, Catherine Byrne, Alastair Ferraro, Martin Christian, Jonathan Evans, Jon Jin Kim, Andrew Lunn, Meeta Mallik, Phil Mason, David Mole, Janet Craze, Nicholas Sangala, Mark Uniacke, Ellon McGregor, Stewart Lambie, N. Bhandary, Oliver Flossmann, M. Mohteshamzadeh, A. Abeyaratne, Coralie Bingham, Rhian L. Clissold, Lucy Smyth, John Connolly, Ben Reynolds, John Neary, Joanne Bell, Sarah Roxburgh, Joyce Popoola, Rosie Donne, Nicholas Fardon, Arif Khwaja, Shareen Siddiqi, Gurinder Kumar, Steve Kardasz, Iain Moore, D. Tez, Jamie Willows, Rachel Davison, John Harty, William Wong, Andrew J. Williams, Daniel Gale, Richard J. Coward, C. Inward, Martin Mráz, Waqar Ayub, Andrew Short, David Lappin, Richard Baines, Girish Bommayya, Kris Houlberg, Imran Saif, Rodney Gilbert, Sian Griffin, Graham Smith, Judith Van Der Voort, Jayanthi Chandar, Michael Freundlich, Frank McCarroll, Germaine Wong, P. Laboi, Rebekah Molyneux   +136 more
semanticscholar   +1 more source

Overlapping Atypical Hemolytic Uremic Syndrome and C3 Glomerulopathy with Mutation in CFI in a Japanese Patient: A Case Report

Internal medicine, 2023
A 34-year-old Japanese man presented with blurred vision, headache, nausea, anemia, thrombocytopenia, and severe renal dysfunction. Thrombotic microangiopathy was initially suspected to have been caused by malignant hypertension.
Kosuke Osawa, Shuto Yamamoto, Yukiko Yamano, Ayako Kita, Kota Okamoto, Noritoshi Kato, Yoshitaka Tatematsu, F. Kojima, Masaki Ohya, Shigeo Hara, Shin-ichi Murata, Norimitsu Inoue, S. Maruyama, Shin-Ichi Araki   +13 more
semanticscholar   +1 more source

End-Stage Kidney Disease Resulting from Atypical Hemolytic Uremic Syndrome after Receiving AstraZeneca SARS-CoV-2 Vaccine: A Case Report

Vaccines, 2023
Hemolytic uremic syndrome (HUS) is classically described as a triad of nonimmune hemolytic anemia, thrombocytopenia, and acute kidney injury. Atypical HUS (aHUS) is a rare variant of the disease, and it accounts for 5–10% of the cases.
Mohammed Tawhari, Moustafa S Alhamadh, A. Alhabeeb, Ziyad Almudayfir, Mansoor Radwi   +4 more
semanticscholar   +1 more source