Results 41 to 50 of about 24,341 (292)

Eculizumab is a safe and effective treatment in pediatric patients with atypical hemolytic uremic syndrome [PDF]

, 2016
Atypical hemolytic uremic syndrome (aHUS) is caused by alternative complement pathway dysregulation, leading to systemic thrombotic microangiopathy (TMA) and severe end-organ damage.
Al-Akash, Samhar I, Ardissino, Gianluigi, Bedrosian, Camille L, Evans, Jonathan, Fila, Marc, Greenbaum, Larry A, Henning, Paul, Licht, Christoph, Lieberman, Kenneth V, Maringhini, Silvio, Ogawa, Masayo, Pape, Lars, Rees, Lesley, van de Kar, Nicole CAJ, Vande Walle, Johan   +14 more
core   +2 more sources

Terminal complement inhibitor eculizumab in atypical hemolytic-uremic syndrome.

New England Journal of Medicine, 2013
BACKGROUND Atypical hemolytic-uremic syndrome is a genetic, life-threatening, chronic disease of complement-mediated thrombotic microangiopathy. Plasma exchange or infusion may transiently maintain normal levels of hematologic measures but does not treat
C. Legendre, C. Licht, P. Muus, Lawrence Greenbaum, S. Babu, C. Bedrosian, C. Bingham, D. Cohen, Yahsou Delmas, K. Douglas, F. Eitner, T. Feldkamp, D. Fouque, R. Furman, O. Gaber, M. Herthelius, M. Hourmant, D. Karpman, Y. Lebranchu, C. Mariat, J. Menne, B. Moulin, J. Nürnberger, M. Ogawa, G. Remuzzi, T. Richard, R. Sberro-Soussan, B. Severino, N. Sheerin, A. Trivelli, L. Zimmerhackl, T. Goodship, C. Loirat   +32 more
semanticscholar   +1 more source

Quantifying the economic effects of ravulizumab versus eculizumab treatment in patients with atypical hemolytic uremic syndrome

Journal of Medical Economics, 2022
Aims This study compared the aggregate duration of treatment administration of approved eculizumab and ravulizumab treatment regimens and resultant productivity implications for patients with atypical hemolytic uremic syndrome (aHUS) and their caregivers.
A. Levy, Peter Chen, K. Johnston, Yan Wang, E. Popoff, I. Tomazos   +5 more
semanticscholar   +1 more source

Atypical Hemolytic Uremic Syndrome Occurring After Receipt of mRNA-1273 COVID-19 Vaccine Booster: A Case Report

American Journal of Kidney Diseases, 2022
Atypical hemolytic uremic syndrome (aHUS) is a subtype of thrombotic microangiopathy (TMA) characterized by a dysregulation of the alternative complement pathway.
K. Claes, I. Geerts, W. Lemahieu, A. Wilmer, D. Kuypers, P. Koshy, S. Ombelet   +6 more
semanticscholar   +1 more source

Clinical characteristics and outcomes of a patient population with atypical hemolytic uremic syndrome and malignant hypertension: analysis from the Global aHUS registry

JN. Journal of Nephrology (Milano. 1992), 2022
Introduction Atypical hemolytic uremic syndrome (aHUS) is a rare form of thrombotic microangiopathy (TMA) often caused by alternative complement dysregulation.
J. Halimi, I. Al-Dakkak, K. Anokhina, G. Ardissino, C. Licht, W. Lim, A. Massart, F. Schaefer, J. Walle, E. Rondeau   +9 more
semanticscholar   +1 more source

Hyperfunctional complement C3 promotes C5-dependent atypical hemolytic uremic syndrome in mice [PDF]

, 2019
Atypical hemolytic uremic syndrome (aHUS) is frequently associated in humans with loss-of-function mutations in complement-regulating proteins or gain-of-function mutations in complement-activating proteins.
Atkinson, John P, Barlow, Paul N, Cook, H. T, Cooke, Katie, Denton, Harriet, Kavanagh, David, Liszewski, M. K, Marchbank, Kevin J, Pappworth, Isabel Y, Pickering, Matthew C, Smith-Jackson, Kate, Yang, Yi   +11 more
core   +3 more sources

Genetics of Atypical Hemolytic Uremic Syndrome (aHUS) [PDF]

Seminars in Thrombosis and Hemostasis, 2014
Hemolytic uremic syndrome (HUS) is a rare, life-threatening disease characterized by thrombocytopenia, microangiopathic hemolytic anemia, and acute renal failure. The atypical form of HUS (aHUS), representing 5 to 10% of cases, lacks the association with infection by Shiga toxin producing Escherichia coli strains that characterizes the commonest ...
Rodriguez de Cordoba, Santiago, Subias Hidalgo, Marta, Pinto, Sheila, Tortajada Alonso, Agustín   +3 more
openaire   +4 more sources

Hemolytic uremic syndrome related to Shiga-like toxin-producing Escherichia coli with encephalitis hiding a human herpesvirus-6 infection: a case report

Journal of Medical Case Reports, 2021
Background Cardiac and neurological involvement in hemolytic uremic syndrome are life-threatening complications. The most frequent complications of cardiac involvement in hemolytic uremic syndrome are myocarditis and cardiac dysfunction due to fluid ...
Sophie Mounier, Arthur Gavotto, Julie Tenenbaum, Pierre Meyer, Marc Fila, Julien Baleine   +5 more
doaj   +1 more source

Infection frequently triggers thrombotic microangiopathy in patients with preexisting risk factors : a single-institution experience [PDF]

, 2010
Thrombotic microangiopathies are rare conditions characterized by microangiopathic hemolytic anemia, microthrombi, and multiorgan insult. The disorders, which include hemolytic uremic syndrome and thrombotic thrombocytopenic purpura, are often acute and ...
Catlow, Jamie, Douglas, Kenneth W., Green, Rachel, Pollock, Kevin G.J., Young, David   +4 more
core   +1 more source

Baseline characteristics and evolution of Brazilian patients with atypical hemolytic uremic syndrome: first report of the Brazilian aHUS Registry

Clinical Kidney Journal, 2022
Background Atypical hemolytic uremic syndrome (aHUS) is an ultra-rare disease. Therefore, studies involving large samples are scarce, making registries powerful tools to evaluate cases. We present herein the first analysis of the Brazilian aHUS Registry (
M. Vaisbich, Luís Gustavo Modelli de Andrade, Precil Diego Miranda de Menezes Neves, L. Palma, M. C. D. de Castro, Cassiano Augusto Braga Silva, Maria Izabel Neves de Holanda Barbosa, M. Penido, Oreste Angelo Ferra Neto, R. Sobral, S. M. Miranda, Stanley de Almeida Araújo, I. Pietrobom, H. Takase, C. Ribeiro, Rafael Marques da Silva, César Augusto Almeida de Carvalho, D. Machado, Ana Mateus Simões Teixeira E Silva, A. da Silva, E. R. Russo, Flávio Henrique Soares Barros, J. C. Nasserala, L. S. C. de Oliveira, Lucimary de Castro Sylvestre, Rafael Weissheimer, Sueli de Oliveira Nascimento, Gilson Bianchini, Fellype de Carvalho Barreto, V. Veloso, P. Fortes, V. Colares, J. G. Gomes, André Falcão Pedrosa Leite, Pablo Girardelli Mendonça Mesquita, O. M. Vieira-Neto   +35 more
semanticscholar   +1 more source