Classical and Atypical Scrapie in Sheep and Goats. Review on the Etiology, Genetic Factors, Pathogenesis, Diagnosis, and Control Measures of Both Diseases [PDF]
Animals, 2021 Prion diseases, such as scrapie, are neurodegenerative diseases with a fatal outcome, caused by a conformational change of the cellular prion protein (PrPC), originating with the pathogenic form (PrPSc).
Cristina Acín +2 more
exaly +4 more sources
Atypical Scrapie Isolates Involve a Uniform Prion Species with a Complex Molecular Signature [PDF]
PLoS ONE, 2011 The pathobiology of atypical scrapie, a prion disease affecting sheep and goats, is still poorly understood. In a previous study, we demonstrated that atypical scrapie affecting small ruminants in Switzerland differs in the neuroanatomical distribution ...
Hubert Laude +2 more
exaly +3 more sources
Experimental transmission of ovine atypical scrapie to cattle [PDF]
Veterinary Research, 2023 Classical bovine spongiform encephalopathy (BSE) in cattle was caused by the recycling and feeding of meat and bone meal contaminated with a transmissible spongiform encephalopathy (TSE) agent but its origin remains unknown. This study aimed to determine
Timm Konold +10 more
doaj +2 more sources
PrPres in placental tissue following experimental transmission of atypical scrapie in ARR/ARR sheep is not infectious by Tg338 mouse bioassay [PDF]
PLoS ONE, 2022 Nor98-like atypical scrapie is a sporadic disease that affects the central nervous system of sheep and goats that, in contrast to classical scrapie, is not generally regarded as naturally transmissible.
Robert B. Piel +7 more
doaj +3 more sources
Bona fide atypical scrapie faithfully reproduced for the first time in a rodent model [PDF]
Acta Neuropathologica Communications, 2022 Atypical Scrapie, which is not linked to epidemics, is assumed to be an idiopathic spontaneous prion disease in small ruminants. Therefore, its occurrence is unlikely to be controlled through selective breeding or other strategies as it is done for ...
Enric Vidal +25 more
doaj +2 more sources
Phenotype shift from atypical scrapie to CH1641 following experimental transmission in sheep. [PDF]
PLoS ONE, 2015 The interactions of host and infecting strain in ovine transmissible spongiform encephalopathies are known to be complex, and have a profound effect on the resulting phenotype of disease.
Marion M Simmons +6 more
doaj +2 more sources
PLoS ONE, 2021 Scrapie is a transmissible spongiform encephalopathy that occurs in sheep. Atypical/Nor98 scrapie occurs in sheep that tend to be resistant to classical scrapie and it is thought to occur spontaneously.
Eric Cassmann +2 more
exaly +2 more sources
Atypical/Nor98 Scrapie Infectivity in Sheep Peripheral Tissues [PDF]
PLoS Pathogens, 2011 Atypical/Nor98 scrapie was first identified in 1998 in Norway. It is now considered as a worldwide disease of small ruminants and currently represents a significant part of the detected transmissible spongiform encephalopathies (TSE) cases in Europe ...
François Schelcher +2 more
exaly +2 more sources
Diversity in Neuroanatomical Distribution of Abnormal Prion Protein in Atypical Scrapie
PLoS Pathogens, 2007 Scrapie is a transmissible spongiform encephalopathy (TSE) in sheep and goats. In recent years, atypical scrapie cases were identified that differed from classical scrapie in the molecular characteristics of the disease-associated pathological prion ...
Cord Drögemüller +2 more
exaly +2 more sources
Experimental Oral Transmission of Atypical Scrapie to Sheep [PDF]
Emerging Infectious Diseases, 2011 To investigate the possibility of oral transmission of atypical scrapie in sheep and determine the distribution of infectivity in the animals’ peripheral tissues, we challenged neonatal lambs orally with atypical scrapie; they were then killed at 12 or ...
Marion M. Simmons +10 more
doaj +2 more sources