EFSA Journal, Volume 21, Issue 10, October 2023., 2023 Abstract The Czech Republic submitted a request to the European Commission to be recognised as a Member State with negligible risk of classical scrapie. EFSA has been asked to assess if the Czech Republic in its application has demonstrated for a period of at least 7 years (2015–2021) and proposed for the future, that a sufficient number of ovine and ...
European Food Safety Authority (EFSA) +5 more
wiley +1 more source
Proteinase K-Resistant Material in ARR/VRQ Sheep Brain Affected with Classical Scrapie Is Composed Mainly of VRQ Prion Protein [PDF]
, 2011 Classical scrapie is a prion disease in sheep and goats. In sheep, susceptibility to disease is genetically influenced by single amino acid substitutions.
Bossers, A. +28 more
core +1 more source
Diagnosis in Scrapie: Conventional Methods and New Biomarkers
Pathogens, 2023 Scrapie, a naturally occurring prion disease affecting goats and sheep, comprises classical and atypical forms, with classical scrapie being the archetype of transmissible spongiform encephalopathies.
Diego Sola +12 more
doaj +1 more source
Monitoring of chronic wasting disease (CWD) (IV)
EFSA Journal, Volume 21, Issue 4, April 2023., 2023 Abstract The European Commission requested an analysis of the Chronic Wasting Disease (CWD) monitoring programme in Norway, Sweden, Finland, Iceland, Estonia, Latvia, Lithuania and Poland (9 January 2017–28 February 2022). Thirteen cases were detected in reindeer, 15 in moose and 3 in red deer.
EFSA Panel on Biological Hazards (BIOHAZ) +24 more
wiley +1 more source
Retrospective surveillance of atypical scrapie in Japan [PDF]
, 2008 Recently, atypical scrapie cases have increased mainly in genetically scrapie-resistant sheep in Europe. The characteristics of the abnormal isoform of prion protein (PrP^Sc) and its deposition pattern in the brain differ between atypical and classical ...
IMAMURA, Morikazu +17 more
core +1 more source
Breeding with resistant rams leads to rapid control of classical scrapie in affected sheep flocks [PDF]
, 2011 Susceptibility to scrapie, a transmissible spongiform encephalopathy in sheep, is modulated by the genetic make-up of the sheep. Scrapie control policies, based on selecting animals of resistant genotype for breeding, have recently been adopted by the ...
van Roermund, H.J.W. +19 more
core +1 more source
Differentiation of ruminant transmissible spongiform encephalopathy isolate types, including bovine spongiform encephalopathy and CH1641 scrapie [PDF]
, 2010 With increased awareness of the diversity of transmissible spongiform encephalopathy (TSE) strains in the ruminant population, comes an appreciation of the need for improved methods of differential diagnosis. Exposure to bovine spongiform encephalopathy (
Bossers, A. +12 more
core +1 more source
Animals, 2021 Wasting disease in small ruminants is frequently detected at slaughterhouses. The wasting disorder is manifested by the deterioration of the nutritional and physiological state of the animal indicated by thinness, emaciation, and cachexia.
Alexandra Esteves +22 more
doaj +1 more source
Scrapie prevalence in sheep of susceptible genotype is declining in a population subject to breeding for resistance [PDF]
, 2010 Background Susceptibility of sheep to scrapie infection is known to be modulated by the PrP genotype of the animal. In the Netherlands an ambitious scrapie control programme was started in 1998, based on genetic selection of animals for breeding.
Bossers, A. +18 more
core +1 more source
Incidence of infection in Prnp ARR/ARR sheep following experimental inoculation with or natural exposure to classical scrapie. [PDF]
PLoS ONE, 2014 The prion protein gene (Prnp) is highly influential in determining risk and susceptibility of sheep exposed to classical scrapie. Sheep homozygous for alanine at codon 136 and arginine at codons 154 and 171 (ARR/ARR) of the Prnp gene are historically ...
Martin Jeffrey +5 more
doaj +1 more source