Stage-specific proteomes from onchocerca ochengi, sister species of the human river blindness parasite, uncover adaptations to a nodular lifestyle [PDF]
, 2016 Despite 40 years of control efforts, onchocerciasis (river blindness) remains one of the most important neglected tropical diseases, with 17 million people affected.
Adam +155 more
core +6 more sources
Three Is Better than One: A Multimetal Complex that Triggers Immunogenic Cell Death
Angewandte Chemie, Volume 137, Issue 39, September 22, 2025.A triple metal prodrug that codelivers PtII, RuII, and AuI species triggers a potent immunogenic cell death (ICD) response via combined Type I/II pathways. The tri‐metallic scaffold promotes tumor inhibition, immune memory, and peripheral leukocyte activation, offering a next‐generation chemo‐immunotherapeutic approach (created in BioRender.
Tomer Babu +4 more
wiley +1 more source
Potential Anticancer Activity of Auranofin
Chemical and Pharmaceutical Bulletin, 2019 Gold compounds have a long history of use in medicine. Auranofin was developed more than 30 years ago as an oral therapy for rheumatoid arthritis. Now, however, auranofin is rarely used in clinical practice despite its efficacy for treating rheumatoid arthritis because more novel antirheumatic medications are available.
Isao, Momose +2 more
openaire +5 more sources
Toxins, 2017 The AB-type protein toxin from Pasteurella multocida (PMT) contains a functionally important disulfide bond within its catalytic domain, which must be cleaved in the host cell cytosol to render the catalytic domain of PMT into its active conformation ...
Stefan Carle +4 more
doaj +1 more source
Nitro-fatty acids and cyclopentenone prostaglandins share strategies to activate the Keap1-Nrf2 system: a study using green fluorescent protein transgenic zebrafish [PDF]
, 2011 Nitro-fatty acids are electrophilic fatty acids produced in vivo from nitrogen peroxide that have many physiological activities. We recently demonstrated that nitro-fatty acids activate the Keap1-Nrf2 system, which protects cells from damage owing to ...
Freeman Bruce A. +12 more
core +1 more source
A systematic review and meta-analysis of complementary and alternative medicine in asthma [PDF]
, 2017 Asthma is a chronic, inflammatory lung disease affecting around 235 million people worldwide. Conventional medications in asthma are not curative and patients have significant concerns regarding their side effects. Consequently, many asthma patients turn
Abidi +12 more
core +3 more sources
Contact dermatitis from topical auranofin
Journal of the American Academy of Dermatology, 1995 Auranofin is an organogold complex composed of gold, thiosugar, and triethylphosphine that has been successfully used parenterally in the treatment of rheumatoid arthritis. More recently, a crude 0.18% auranofin ointment was used to treat psoriasis, resulting in clearing of lesions in some patients. 1 To confirm and extend these preliminary findings, a
J G, Marks +5 more
openaire +2 more sources
Heteroleptic Copper(I) Complexes of "Scorpionate" Bis-pyrazolyl Carboxylate Ligand with Auxiliary Phosphine as Potential Anticancer Agents: An Insight into Cytotoxic Mode [PDF]
, 2017 New copper(I) complexes [CuCl(PPh3)(L)] (1: L = LA = 4-carboxyphenyl)bis(3,5-dimethylpyrazolyl)methane; (2: L = LB = 3-carboxyphenyl)bis(3,5-dimethylpyrazolyl)methane) were prepared and characterised by elemental analysis and various spectroscopic ...
Akbarsha, Mohammad Abdulkader +11 more
core +1 more source
Frontiers in Oncology, 2019 Prima-1Met (APR-246) was previously shown to be dependent on glutathione inhibition and on ROS induction in cancer cells with mutated or deleted TP53.
Benoit Tessoulin +15 more
doaj +1 more source