Effects of inhibiting antioxidant pathways on cellular hydrogen sulfide and polysulfide metabolism [PDF]
, 2019 Elaborate antioxidant pathways have evolved to minimize the threat of excessive reactive oxygen species (ROS) and to regulate ROS as signaling entities.
Gao, Yan, Olson, Kenneth R.
core +1 more source
PLoS ONE, 2022 Neisseria gonorrhoeae has been classified by the U.S. Centers for Disease Control and Prevention as an urgent threat due to the rapid development of antibiotic resistance to currently available antibiotics.
Ahmed E. M. Elhassanny +2 more
doaj +2 more sources
Computational and Structural Biotechnology Journal, 2023 Pseudomonas aeruginosa is a leading cause of hospital-acquired infections. Treatment of P. aeruginosa infections is difficult given its multiple virulence mechanisms, intrinsic antibiotic resistance mechanisms, and biofilm-forming ability.
Yingdan Zhang +6 more
doaj +1 more source
Auranofin is highly efficacious against Toxoplasma gondii in vitro and in an in vivo experimental model of acute toxoplasmosis. [PDF]
PLoS Neglected Tropical Diseases, 2014 The mainstay of toxoplasmosis treatment targets the folate biosynthetic pathways and has not changed for the last 50 years. The activity of these chemotherapeutic agents is restricted to one lifecycle stage of Toxoplasma gondii, they have significant ...
Rosa M Andrade +3 more
doaj +1 more source
Adipocytes cause leukemia cell resistance to daunorubicin via oxidative stress response. [PDF]
, 2016 Adipocytes promote cancer progression and impair treatment, and have been shown to protect acute lymphoblastic leukemia (ALL) cells from chemotherapies. Here we investigate whether this protection is mediated by changes in oxidative stress.
Behan, James W +6 more
core +1 more source
Linking genotoxicity and cytotoxicity with membrane fluidity: A comparative study in ovarian cancer cell lines following exposure to auranofin [PDF]
, 2016 publisher: Elsevier articletitle: Linking genotoxicity and cytotoxicity with membrane fluidity: A comparative study in ovarian cancer cell lines following exposure to auranofin journaltitle: Mutation Research/Genetic Toxicology and Environmental ...
Dodd, NJF +4 more
core +2 more sources
Auranofin and Baicalin Inhibit Clostridioides difficile Growth and Sporulation: An In vitro Study
Journal of Pure and Applied Microbiology, 2022 Clostridioides difficile is a principal cause of hospital-acquired gastrointestinal infections, with sporulation and toxin production being key determinants in the disease pathogenesis.
Lamiaa A. Madkour
doaj +1 more source
Novel role for thioredoxin reductase-2 in mitochondrial redox adaptations to obesogenic diet and exercise in heart and skeletal muscle [PDF]
, 2013 Increased fatty acid availability and oxidative stress are physiological consequences of exercise (Ex) and a high-fat, high-sugar (HFHS) diet. Despite these similarities, the global effects of Ex are beneficial, whereas HFHS diets are largely deleterious
Adimora +58 more
core +1 more source
Frontiers in Pharmacology, 2019 Pelvic and abdominal radiotherapy plays an important role in eradication of malignant cells; however, it also results in slight intestinal injury.
Eun Sang Lee +6 more
doaj +1 more source
Recent advances: rheumatology [PDF]
, 2000 No abstract ...
Madhok, R., Kerr, H., Capell, H.A.
core +6 more sources