Results 1 to 10 of about 247,095 (343)

Idiopathic inflammatory myopathies lack neutralising autoantibodies to type- I, II and III interferons. [PDF]

RMD Open
Objective To determine whether autoantibodies against interferons are present and play a role in disease modulation in idiopathic inflammatory myopathies (IIMs).Methods We screened for autoantibodies against a large number of interferons (IFNs) and other
Behere A, Mildner H, Peralta Garcia I, Pérez Bucio C, Lundberg I, Horuluoglu B, Landegren N.   +6 more
europepmc   +2 more sources

VEGF controls microglial phagocytic response to amyloid-β

Frontiers in Cellular Neuroscience, 2023
Microglial cells are well known to be implicated in the pathogenesis of Alzheimer’s disease (AD), due to the impaired clearance of amyloid-β (Aβ) protein.
Priscille de Gea, Sarah Benkeder, Pauline Bouvet, Mélanie Aimard, Naura Chounlamountri, Jérôme Honnorat, Jérôme Honnorat, Le Duy Do, Le Duy Do, Claire Meissirel   +9 more
doaj   +1 more source

Conformation-stabilizing ELISA and cell-based assays reveal patient subgroups targeting three different epitopes of AGO1 antibodies

Frontiers in Immunology, 2022
Autoantibodies (Abs) are biomarkers for many disease conditions and are increasingly used to facilitate diagnosis and treatment decisions. To guarantee high sensitivity and specificity, the choice of their detection method is crucial.
Christian P. Moritz, Christian P. Moritz, Christian P. Moritz, Le-Duy Do, Le-Duy Do, Yannick Tholance, Yannick Tholance, Yannick Tholance, Pierre-Baptiste Vallayer, Véronique Rogemond, Véronique Rogemond, Bastien Joubert, Bastien Joubert, Karine Ferraud, Karine Ferraud, Coralie La Marca, Coralie La Marca, Jean-Philippe Camdessanché, Jean-Philippe Camdessanché, Jean-Philippe Camdessanché, Jean-Philippe Camdessanché, Jean-Philippe Camdessanché, Jérôme Honnorat, Jérôme Honnorat, Jérôme Honnorat, Jean-Christophe Antoine, Jean-Christophe Antoine, Jean-Christophe Antoine, Jean-Christophe Antoine, Jean-Christophe Antoine   +29 more
doaj   +1 more source

Autoantibodies against complement factor B in rheumatoid arthritis

Frontiers in Immunology, 2023
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disorder affecting the joints. Many patients carry anti-citrullinated protein autoantibodies (ACPA).
Alexandra T. Matola, Alexandra T. Matola, Angéla Fülöp, Bernadette Rojkovich, György Nagy, György Nagy, György Nagy, György Nagy, Gabriella Sármay, Mihály Józsi, Mihály Józsi, Barbara Uzonyi, Barbara Uzonyi   +12 more
doaj   +1 more source

The significance of preclinical anti-BP180 autoantibodies

Frontiers in Immunology, 2022
Bullous pemphigoid (BP) is the most common autoimmune subepidermal blistering disease. Although the pathomechanism of BP onset has yet to be elucidated in detail, BP autoantibodies targeting two hemidesmosomal components, BP180 and BP230, are known to ...
Yosuke Mai, Kentaro Izumi, Shoko Mai, Hideyuki Ujiie   +3 more
doaj   +1 more source

Autoantibodies predict type 1 diabetes after gestational diabetes – a 23-year cohort study

Frontiers in Endocrinology, 2023
ObjectiveTo study the predictive value of autoantibodies for type 1 (T1DM) and type 2 (T2DM) diabetes morbidity after gestational diabetes (GDM) in a 23-year follow-up study.DesignProspective population-based cohort study.MethodsWe studied 391 women with
Kaisu Luiro, Anna-Maaria Auvinen, Anna-Maaria Auvinen, Juha Auvinen, Juha Auvinen, Jari Jokelainen, Ilkka Järvelä, Mikael Knip, Mikael Knip, Mikael Knip, Juha S. Tapanainen, Juha S. Tapanainen, Juha S. Tapanainen, Juha S. Tapanainen   +13 more
doaj   +1 more source

Immunoglobulin E and G autoantibodies against eosinophil proteins in children and adults with asthma and healthy subjects

World Allergy Organization Journal, 2023
Background: Autoimmune IgG response has been described in the pathogenesis of asthma in adults, but IgE autoimmunity has been little explored. Considering high levels of blood eosinophils and immunoglobulin E in asthmatic patients, the possibility of IgE
Jorge Sánchez, MD, MSc, EAC, PhD, Andres Sánchez Biol, MSc, Marlon Múnera Biol, PhD, Elizabeth García, MD, EAC, Juan-Felipe López, MD, MSc   +4 more
doaj   +1 more source

Affinity purification of serum-derived anti-IA-2 autoantibodies in type 1 diabetes using a novel MBP-IA-2 fusion protein

Biochemistry and Biophysics Reports, 2023
Autoantibodies targeting epitopes contained within the intracellular domain (IC) of the protein phosphatase-like islet antigen 2 (IA-2) are a common marker of autoimmune type 1 diabetes (T1D), however the isolation of genuine, serum derived anti-IA-2 ...
Thilini Mendis, Barbora Filipova, Jing Jing Wang, Massimo Pietropaolo, Michael W. Jackson   +4 more
doaj   +1 more source

Angiotensin type-1 receptor and ACE2 autoantibodies in Parkinson´s disease

npj Parkinson's Disease, 2022
The role of autoimmunity in neurodegeneration has been increasingly suggested. The renin-angiotensin system (RAS) autoantibodies play a major role in several peripheral inflammatory processes.
Carmen M. Labandeira, Maria A. Pedrosa, Aloia Quijano, Rita Valenzuela, Pablo Garrido-Gil, Mariña Sanchez-Andrade, Juan A. Suarez-Quintanilla, Ana I. Rodriguez-Perez, Jose L. Labandeira-Garcia   +8 more
doaj   +1 more source

Physiological Changes in the Levels of Anti-Cytokine Autoantibodies in Early Pregnancy Are Missing in Pregnant Women with Hashimoto’s Thyroiditis

Journal of Immunology Research, 2023
T helper type 1 (Th1) and inflammatory cytokines play essential roles in early pregnancy and also in the pathogenesis of Hashimoto’s thyroiditis (HT).
Szabina Erdő-Bonyár, Diána Simon, Anna Bajnok, Jasper Nörenberg, Tímea Serény-Litvai, Ákos Várnagy, Kálmán Kovács, Eszter Hantosi, Emese Mezősi, Tímea Berki   +9 more
doaj   +1 more source