A possible ligand of serum origin for the kidney autoantigen of Heymann nephritis. [PDF]
John J. Kanalas, S. P. Makker
openalex +1 more source
Treatment options for immune‐related adverse events associated with immune checkpoint inhibitors
Abstract The immunotherapy revolution with the use of immune checkpoint inhibitors (ICIs) started with the clinical use of the first ICI, ipilimumab, in 2011. Since then, the field of ICI therapy has rapidly expanded — with the FDA approval of 10 different ICI drugs so far and their incorporation into the therapeutic regimens of a range of malignancies.
Yu Hua Chen+3 more
wiley +1 more source
Molecular cloning of cDNA encoding Sm autoantigen: Derivation of a cDNA for a B polypeptide of the U series of small nuclear ribonucleoprotein particles [PDF]
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Bullous Pemphigoid Presenting as Immunoglobulin M Pemphigoid
JEADV Clinical Practice, EarlyView.
D. Didona+5 more
wiley +1 more source
RBM39 Promotes Base Excision Repair to Facilitate the Progression of HCC by Stabilising OGG1 mRNA
Targeting RBM39 attenuates BER via destabilising OGG1 mRNA and potentiates KBrO3‐induced oxidative stress in HCC. Our study represents a valuable treatment strategy combining indisulam and an oxidative stress inducer in HCC. ABSTRACT Targeting base excision repair (BER) has been an attractive strategy in cancer therapeutics.
Hongda An+7 more
wiley +1 more source
Exploration of the blocking effect of Fab fragment of IgG autoantibody on erythrocyte autoantigens
Objective To use Fab segments of autoantibodies to bind to autoantigens on red blood cells in order to block the binding of intact autoantibodies to the autoantigens.
Haitao HUANG, Xuehong WEN
doaj +1 more source
Description and partial characterization of a nucleolar RNA-associated autoantigen defined by a human monoclonal antibody. [PDF]
Nicholas Chiorazzi, Westley H. Reeves
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CRISPR‐Cas systems offer transformative genome editing capabilities for precise manipulation of cellular genes. This enables two main therapeutic avenues: ex vivo modification of patient cells for re‐transplantation or direct in vivo gene targeting via advanced delivery methods.
Bahareh Farasati Far+4 more
wiley +1 more source
Clinical and immunopathological spectrum of immunoglobulin M pemphigoid: a multicenter case series
Summary Background and Objectives Pemphigoid diseases are primarily mediated by IgG or IgA autoantibodies against the cutaneous basement membrane zone (BMZ). Although recent observations suggest the existence of exclusively IgM‐mediated pemphigoid disease, a larger study is lacking.
Kaan Yilmaz+15 more
wiley +1 more source