Results 21 to 30 of about 59,330 (297)

Preclinical Models to Evaluate the Human Response to Autoantigen and Antigen-Specific Immunotherapy in Human Type 1 Diabetes

Frontiers in Endocrinology, 2022
Type 1 Diabetes (T1D) is an autoimmune disease that results from the destruction of pancreatic islet β-cells by auto-reactive T cells. The clinical management of T1D faces the lack of fully predictive biomarkers in its preclinical stage and of antigen ...
Pamela Houeiss, Pamela Houeiss, Christian Boitard, Christian Boitard, Sandrine Luce, Sandrine Luce   +5 more
doaj   +1 more source

B‐cell receptors of EBV‐negative Burkitt lymphoma bind modified isoforms of autoantigens

eJHaem, 2022
Burkitt lymphoma (BL) represents the most aggressive B‐cell‐lymphoma. Beside the hallmark of IG‐MYC‐translocation, surface B‐cell receptor (BCR) is expressed, and mutations in the BCR pathway are frequent.
Theresa Bock, Moritz Bewarder, Onur Cetin, Natalie Fadle, Evi Regitz, Eva C. Schwarz, Jana Held, Sophie Roth, Stefan Lohse, Thorsten Pfuhl, Rabea Wagener, Sigrun Smola, Sören L. Becker, Rainer Maria Bohle, Lorenz Trümper, Reiner Siebert, Martin‐Leo Hansmann, Michael Pfreundschuh, Hans G. Drexler, Markus Hoth, Boris Kubuschok, Klaus Roemer, Klaus‐Dieter Preuss, Sylvia Hartmann, Lorenz Thurner   +24 more
doaj   +1 more source

Oral Dysbiosis and Autoimmunity: From Local Periodontal Responses to an Imbalanced Systemic Immunity. A Review

Frontiers in Immunology, 2020
The current paradigm of onset and progression of periodontitis includes oral dysbiosis directed by inflammophilic bacteria, leading to altered resolution of inflammation and lack of regulation of the inflammatory responses.
Lina J. Suárez, Hernan Garzón, Silie Arboleda, Adriana Rodríguez   +3 more
doaj   +1 more source

Identification of two major autoantigens negatively regulating endothelial activation in Takayasu arteritis

Nature Communications, 2020
The presence of antiendothelial cell antibodies (AECAs) has been documented in Takayasu arteritis (TAK), a chronic granulomatous vasculitis. Here, we identify cell-surface autoantigens using an expression cloning system.
Tomoyuki Mutoh, T. Shirai, T. Ishii, Y. Shirota, F. Fujishima, Fumiaki Takahashi, Y. Kakuta, Y. Kanazawa, A. Masamune, Y. Saiki, H. Harigae, H. Fujii   +11 more
semanticscholar   +1 more source

Neoepitopes in Type 1 Diabetes: Etiological Insights, Biomarkers and Therapeutic Targets

Frontiers in Immunology, 2021
The mechanisms underlying type 1 diabetes (T1D) pathogenesis remain largely unknown. While autoantibodies to pancreatic beta-cell antigens are often the first biological response and thereby a useful biomarker for identifying individuals in early stages ...
Teresa Rodriguez-Calvo, James D. Johnson, Lut Overbergh, Jessica L. Dunne   +3 more
doaj   +1 more source

Dysregulated Levels of Circulating Autoantibodies against Neuronal and Nervous System Autoantigens in COVID-19 Patients

Diagnostics, 2023
Background: COVID-19 is a heterogenous disease resulting in long-term sequela in predisposed individuals. It is not uncommon that recovering patients endure non-respiratory ill-defined manifestations, including anosmia, and neurological and cognitive ...
Yael Lavi, Aristo Vojdani, Gilad Halpert, Kassem Sharif, Yuri Ostrinski, Israel Zyskind, Miriam T Lattin, Jason Zimmerman, Jonathan I Silverberg, Avi Z Rosenberg, Yehuda Shoenfeld, Howard Amital   +11 more
doaj   +1 more source

Integration of IgA and IgG Autoantigens Improves Performance of Biomarker Panels for Early Diagnosis of Lung Cancer*

Molecular & Cellular Proteomics, 2020
Lung cancer (LC) remains the leading cause of mortality from malignant tumors worldwide. To identify biomarkers for early detection of LC, we employed the HuProt array platform and ELISA tests to identify and validate for IgA-bound autoantigens, which ...
Jianbo Pan, Lili Yu, Qingwei Wu, Xiaoqin Lin, Shuang Liu, Shaohui Hu, Christian Rosa, D. Eichinger, Ignacio Pino, Heng Zhu, Jiang Qian, Yi Huang   +11 more
semanticscholar   +1 more source

A rare entity: Sympathetic ophthalmia presumably after blunt trauma to the phthisical eye and optical coherence tomography angiography metrics to monitor response to treatment

Clinical Case Reports, 2020
A blunt trauma to a phthisical eye may elicit sympathetic ophthalmia. Non invasive imaging such as use of optical coherence tomography and angiography metrics of the retinal and choroidal vasculature can help monitor response to the treatment.
Anadi Khatri, Satish Timalsena, Bal Kumar Khatri, Muna Kharel, Sudhir Gautam, Jeena Gurung, Santosh Kafle   +6 more
doaj   +1 more source

Molecular Insights Into the Relationship Between Autoimmune Thyroid Diseases and Breast Cancer: A Critical Perspective on Autoimmunity and ER Stress

Frontiers in Immunology, 2019
The etiopathologies behind autoimmune thyroid diseases (AITDs) unravel misbehavior of immune components leading to the corruption of immune homeostasis where thyroid autoantigens turn foe to the self.
Safikur Rahman, Ayyagari Archana, Arif Tasleem Jan, Durgashree Dutta, Abhishek Shankar, Jihoe Kim, Rinki Minakshi   +6 more
doaj   +1 more source

Review of presentations at the 6th European Lupus Meeting 3-5 March 2005. [PDF]

, 2005
The 6th European Lupus Meeting was held at the Royal College of Physicians of London and was attended by 450 delegates. The conference brought together leading speakers from Europe and North America who reviewed current knowledge and exciting new ...
Bowman, SJ, Giles, IP, Ioannou, Y, Rahman, A   +3 more
core   +1 more source