Life, 2023 Wet age-related macular degeneration (wAMD) is a chronic inflammation-associated neurodegenerative disease affecting the posterior part of the eye in the aging population.
Sreeraj Kuruppilakath Manikandan +6 more
doaj +1 more source
Genetics and Omics Analysis of Autoimmune Skin Blistering Diseases
Frontiers in Immunology, 2019 Autoimmune blistering diseases (AIBDs) of the skin are characterized by autoantibodies against different intra-/extracellular structures within the epidermis and at the basement membrane zone (BMZ). Binding of the antibodies to their target antigen leads
Michael Olbrich +8 more
doaj +1 more source
Anti-Idiotypic mRNA Vaccine to Treat Autoimmune Disorders
Vaccines, 2023 The 80+ existing autoimmune disorders (ADs) affect billions with little prevention or treatment options, except for temporary symptomatic management, leading to enormous human suffering and a monumental financial burden. The autoantibodies formed in most
Sarfaraz K. Niazi
doaj +1 more source
PSR-MAPMS: A new approach for the interpretable prediction of myelin autoantigenic peptides in multiple sclerosis using multi-source propensity scores. [PDF]
Protein SciAbstract Within the central nervous system, the myelin sheath is composed of elements known as myelin autoantigens that are mistakenly targeted by the immune system in multiple sclerosis (MS). This autoimmune attack leads to the destruction of myelin, resulting in the neurological symptoms characteristic of MS. Identifying myelin autoantigenic peptides
Charoenkwan P +3 more
europepmc +2 more sources
Screening of endocrine organ-specific humoral autoimmunity in 47,XXY Klinefelter's syndrome reveals a significant increase in diabetes-specific immunoreactivity in comparison with healthy control men. [PDF]
, 2015 The aim of this study was to evaluate the frequency of humoral endocrine organ-specific autoimmunity in 47,XXY Klinefelter’s syndrome (KS) by investigating the autoantibody profile specific to type 1 diabetes (T1DM), Addison’s disease (AD), Hashimoto ...
ANZUINI, Antonella +7 more
core +1 more source
Hybrid Insulin Peptides Are Autoantigens in Type 1 Diabetes
Diabetes, 2019 We recently established that hybrid insulin peptides (HIPs) are present in human islets and that T cells reactive to HIPs are found in the residual islets of organ donors with type 1 diabetes (T1D).
R. Baker +7 more
semanticscholar +1 more source
Autoantibodies in Systemic Lupus Erythematosus Target Mitochondrial RNA
Frontiers in Immunology, 2019 The mitochondrion supplies energy to the cell and regulates apoptosis. Unlike other mammalian organelles, mitochondria are formed by binary fission and cannot be directly produced by the cell.
Yann Becker +12 more
doaj +1 more source
Arginine mutation alters binding of a human monoclonal antibody to antigens linked to systemic lupus erythematosus and the antiphospholipid syndrome [PDF]
, 2007 Objective: Previous studies have shown the importance of somatic mutations and arginine residues in the complementarity-determining regions (CDRs) of pathogenic anti-double-stranded DNA (anti-dsDNA) antibodies in human and murine lupus, and in studies of
Giles, I. +7 more
core +1 more source
Decoding the relationship between cow’s milk proteins and development of type 1 diabetes mellitus [PDF]
Archives of Endocrinology and MetabolismObjective To analyze in silico the evidence of molecular mimicry between human beta-cell autoantigens and cow’s milk proteins as a potential type 1 diabetes mellitus (T1DM) trigger.
Luís Jesuino de Oliveira Andrade +5 more
doaj +1 more source
Serum thyroid hormone antibodies are frequent in patients with polyglandular autoimmune syndrome type 3, particularly in those who require thyroxine treatment [PDF]
, 2017 Polyglandular autoimmune syndrome (PAS) type 3 consists of autoimmune thyroid disease (AITD) coexisting with ≥1 non-thyroidal autoimmune disease (NTAID) other than Addison’s disease and hypoparathyroidism. We evaluated the prevalence and repertoire of
Benvenga, Salvatore +8 more
core +1 more source