Results 41 to 50 of about 49,748 (241)
Structural and thermodynamic approach to peptide immunogenicity [PDF]
, 2008 In the conventional paradigm of humoral immunity, B cells recognize their cognate antigen target in its native form. However, it is well known that relatively unstable peptides bearing only partial structural resemblance to the native protein can trigger
Ascherman, DP, Camacho, CJ, Katsumata, Y
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Utility of serological markers in inflammatory bowel diseases: Gadget or magic? [PDF]
, 2007 The panel of serologic markers for inflammatory bowel diseases (IBD) is rapidly expanding. Although anti-Saccharomyces cerevisiae antibodies (ASCA) and atypical perinuclear antineutrophil cytoplasmic antibodies (P-ANCA) remain the most widely ...
Altorjay, István +3 more
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Autoimmunity, 2019 Salivary and lacrimal gland involvement is a characteristic feature of primary Sjögren’s syndrome (pSS), where tissue destruction is mediated by mononuclear cell infiltration, resulting in lacrimal and salivary gland impairment.
Kathrine Skarstein +5 more
doaj +1 more source
Impact of Lymphocyte Apoptosis in Diabetes mellitus
Asian Journal of Medical Sciences, 2011 Diabetes mellitus is a metabolic disorder. It is the most common cause of blindness, kidney failure, and amputations in adults and a leading cause of heart disease and stroke.
Awadhesh K Arya
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The Role of Heat Shock Proteins in Type 1 Diabetes
Frontiers in Immunology, 2021 Type 1 diabetes (T1D) is a T-cell mediated autoimmune disease characterized by recognition of pancreatic β-cell proteins as self-antigens, called autoantigens (AAgs), followed by loss of pancreatic β-cells.
Abu Saleh Md Moin +4 more
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CD1a autoreactive T cells recognize natural skin oils that function as headless antigens [PDF]
, 2014 CD1a autoreactive T cells are common in human blood and skin, but the search for natural autoantigens has been confounded by background T cell responses to CD1 proteins and self lipids.
Altman, John D. +11 more
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Frontiers in Pharmacology, 2020 ObjectiveNatural autoantibodies have been implicated to play a key role in the pathogenesis of coronary heart disease (CHD) because they augment autoimmune activation.
Yin Zhang +15 more
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Autoantibodies against retinal proteins in paraneoplastic and autoimmune retinopathy [PDF]
, 2004 BACKGROUND: Autoimmune retinal degeneration may occur in patients who present with sudden or, less commonly, subacute loss of vision of retinal origin, associated with an abnormal ERG, through the action of autoantibodies against retinal proteins.
AH Milam +31 more
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Testosterone Influence on Gene Expression in Lacrimal Glands of Mouse Models of Sjögren Syndrome [PDF]
, 2019 Purpose: Sjögren syndrome is an autoimmune disorder that occurs almost exclusively in women and is associated with extensive inflammation in lacrimal tissue, an immune-mediated destruction and/or dysfunction of glandular epithelial cells, and a ...
Kam, Wendy R. +6 more
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Ribonucleoprotein complexes as autoantigens [PDF]
Current Opinion in Immunology, 1995 Many intracellular proteins and nucleic acids, that are involved in important biosynthetic pathways, are targeted by autoantibodies occurring spontaneously in the sera of patients with systemic autoimmune diseases. Frequently, the autoantigens are assembled into multicomponent complexes containing both nucleic acid(s) and proteins.
Venrooij, W.J. van, Pruijn, G.J.M.
openaire +3 more sources