Genetics and Omics Analysis of Autoimmune Skin Blistering Diseases
Frontiers in Immunology, 2019 Autoimmune blistering diseases (AIBDs) of the skin are characterized by autoantibodies against different intra-/extracellular structures within the epidermis and at the basement membrane zone (BMZ). Binding of the antibodies to their target antigen leads
Michael Olbrich +8 more
doaj +1 more source
Anti-Idiotypic mRNA Vaccine to Treat Autoimmune Disorders
Vaccines, 2023 The 80+ existing autoimmune disorders (ADs) affect billions with little prevention or treatment options, except for temporary symptomatic management, leading to enormous human suffering and a monumental financial burden. The autoantibodies formed in most
Sarfaraz K. Niazi
doaj +1 more source
Heat shock proteins may be a missing link between febrile infection and cancer tumor rejection via autoantigen molecular mimicry [PDF]
arXiv, 2023 Numerous epidemiological studies suggest febrile infections could confer long-term immunity to certain types of cancers, though the precise mechanisms for this phenomenon remain unclear. Systemic heat-shock responses to fever may be key to understanding the overlapping outcomes of immune responses to infection and cancer. To investigate this hypothesis,
arxiv
Hybrid Insulin Peptides Are Autoantigens in Type 1 Diabetes
Diabetes, 2019 We recently established that hybrid insulin peptides (HIPs) are present in human islets and that T cells reactive to HIPs are found in the residual islets of organ donors with type 1 diabetes (T1D).
R. Baker +7 more
semanticscholar +1 more source
Expression of citrulline and homocitrulline residues in the lungs of non-smokers and smokers : implications for autoimmunity in rheumatoid arthritis [PDF]
, 2015 Introduction: Smoking is a well-established risk factor for rheumatoid arthritis (RA), and it has been proposed that smoking-induced citrullination renders autoantigens immunogenic.
Bracke, Ken +8 more
core +2 more sources
Autoantibodies in Systemic Lupus Erythematosus Target Mitochondrial RNA
Frontiers in Immunology, 2019 The mitochondrion supplies energy to the cell and regulates apoptosis. Unlike other mammalian organelles, mitochondria are formed by binary fission and cannot be directly produced by the cell.
Yann Becker +12 more
doaj +1 more source
Autoimmunity, Autoinflammation, and Infection in Uveitis [PDF]
, 2018 Funding/Support: No funding or grant support. Financial Disclosures: John V. Forrester has received an honorarium for lecturing from Janssen (London, UK). Lucia Kuffova has undertaken consultancy work for Abbvie (London, UK). Andrew D.
Dick, Andrew D. +2 more
core +4 more sources
Decoding the relationship between cow’s milk proteins and development of type 1 diabetes mellitus [PDF]
Archives of Endocrinology and MetabolismObjective To analyze in silico the evidence of molecular mimicry between human beta-cell autoantigens and cow’s milk proteins as a potential type 1 diabetes mellitus (T1DM) trigger.
Luís Jesuino de Oliveira Andrade +5 more
doaj +1 more source
Microarray ELISA for Autoantibody Screening in Connective Tissue Diseases [PDF]
Journal of Clinical and Diagnostic Research, 2012 Objective: This study was performed to demonstrate the use of an ELISA-based microarray technology which is termed as ‘PictArrays’, to identify autoantibody expression patterns in patients with symptoms of autoimmune connective tissue disease ...
Sarita Kumble +3 more
doaj
Autoimmunity, 2019 Study objectives: Narcolepsy type 1 (NT1) is a chronic sleep disorder characterized by loss of hypocretin-producing neurons. Increased NT1 incidence was observed in Sweden following mass-vaccination with Pandemrix®.
M. Wallenius +10 more
semanticscholar +1 more source