Results 71 to 80 of about 43,182 (217)

Identification of novel, clinically correlated autoantigens in the monogenic autoimmune syndrome APS1 by proteome-wide PhIP-Seq

eLife, 2020
The identification of autoantigens remains a critical challenge for understanding and treating autoimmune diseases. Autoimmune polyendocrine syndrome type 1 (APS1), a rare monogenic form of autoimmunity, presents as widespread autoimmunity with T and B ...
Sara E Vazquez, Elise MN Ferré, David W Scheel, Sara Sunshine, Brenda Miao, Caleigh Mandel-Brehm, Zoe Quandt, Alice Y Chan, Mickie Cheng, Michael German, Michail Lionakis, Joseph L DeRisi, Mark S Anderson   +12 more
doaj   +1 more source

CD1a autoreactive T cells recognize natural skin oils that function as headless antigens [PDF]

, 2014
CD1a autoreactive T cells are common in human blood and skin, but the search for natural autoantigens has been confounded by background T cell responses to CD1 proteins and self lipids.
Altman, John D., Birkinshaw, Richard W., Cheng, Tan-Yun, de Jong, Annemieke, Gras, Stephanie, Huang, Shouxiong, Kasmar, Anne, Moody, D. Branch, Peña-Cruz, Victor, Rossjohn, Jamie, Ruan, Daniel T., van Rhijn, Ildiko   +11 more
core   +3 more sources

Frequency and stability of populations of CD4+ and CD4+CD25+Foxp3+CD127lo Treg in healthy adults defined by cytometry using monoclonal antibodies to T cell associated molecules

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Monitoring subpopulations of CD4+ T cells in blood, especially regulatory CD4+CD25+Foxp3+CD127loT cells, has the potential to identify tolerance to transplants and defects that cause autoimmunity. CD45RA is expressed by naïve/resting CD4+, not by activated cells.
Nirupama D. Verma, Ranje Al‐atiyah, Prateek Rakesh, Andrew D. Lam, Christopher Chiu, Giang T. Tran, Bruce M. Hall, Suzanne J. Hodgkinson   +7 more
wiley   +1 more source

Evidence for gliadin antibodies as causative agents in schizophrenia. [PDF]

, 2010
Antibodies to gliadin, a component of gluten, have frequently been reported in schizophrenia. Highly immunogenic B cell epitopes along its length are homologous to numerous proteins relevant to schizophrenia, including members of the DISC1 interactome ...
Chris J. Carter
core   +2 more sources

Pathways to Progressive Disability in Multiple Sclerosis: The Role of Glial Cells in Chronic CNS Inflammation

Glia, EarlyView.
ABSTRACT Multiple sclerosis (MS) is the most common non‐infectious inflammatory CNS disease, characterized by progressive neurodegeneration and focal demyelinated lesions. Traditionally considered an autoimmune disease, MS is driven by the immune system's attack on CNS myelin, resulting in cumulative disability.
Volker Siffrin
wiley   +1 more source

Nasal administration of glutamate decarboxylase (GAD65) peptides induces Th2 responses and prevents murine insulin-dependent diabetes. [PDF]

, 1996
We previously demonstrated that a spontaneous Th1 response against glutamate decarboxylase (GAD65) arises in NOD mice at four weeks in age and subsequently T cell autoimmunity spreads both intramolecularly and intermolecularly.
Atkinson, MA, Clare-Salzler, M, Forsthuber, T, Herschenfeld, A, Kaufman, DL, Lehmann, PV, Tian, J   +6 more
core  

Autoantibodies against retinal proteins in paraneoplastic and autoimmune retinopathy [PDF]

, 2004
BACKGROUND: Autoimmune retinal degeneration may occur in patients who present with sudden or, less commonly, subacute loss of vision of retinal origin, associated with an abnormal ERG, through the action of autoantibodies against retinal proteins.
AH Milam, B Lei, CE Thirkill, DM Jacobson, G Adamus, G Adamus, G Adamus, G Adamus, G Adamus, G Adamus, G Adamus, G Ren, G Tezel, Gaoying Ren, Grazyna Adamus, H Ohguro, H Ohguro, I Maruyama, JB Mizener, JL Keltner, JL Keltner, JL Keltner, JR Heckenlively, MA Murphy, MJ Potter, MR Stanford, MS Savchenko, R Peek, R Peek, Richard G Weleber, SM Whitcup, YH Yoon   +31 more
core   +3 more sources

Factors Affecting Nasal Discharge in Chronic Rhinosinusitis Patients

The Laryngoscope, EarlyView.
This study aimed to identify patient‐specific factors influencing the severity of nasal drainage in chronic rhinosinusitis (CRS) patients. It found that postnasal discharge (PND) was the most severe symptom, with female gender, CRS without nasal polyps, prior endoscopic sinus surgery, and allergies significantly associated with severe PND.
Pranav A. Patel, Ethan M. Kallenberger, Shaun A. Nguyen, Jess C. Mace, Alexander N. Duffy, Zachary M. Soler, Timothy L. Smith, Rodney J. Schlosser   +7 more
wiley   +1 more source

Breaking Boundaries: Chronic Diseases and the Frontiers of Immune Microenvironments

Med Research, EarlyView.
ABSTRACT The immune microenvironment includes immune cells, cytokines, extracellular matrix, vesicles, etc. The interactions between these components form a unique local immune microecology. Although immunity serves as the defense against external pathogens, aberrant immune activation often contributes to disease development.
Guoqing Li, Yuxuan Wan, Alan Jiao, Ke Jiang, Gaoyuan Cui, Jinxin Tang, Simin Yu, Zhengang Hu, Songfeng Zhao, Zhenjie Yi, Lifu Long, Yang Yang, Xuehao Cui, Chunrun Qu   +13 more
wiley   +1 more source

An Epigenetics-Based Hypothesis of Autoantigen Development in Systemic Lupus Erythematosus

Epigenomes, 2020
Currently, we have a limited understanding of mechanisms leading to systemic lupus erythematosus, but we know that genetics, environmental factors, and epigenetics contribute to the disease. One common aspect of the various environmental triggers is that
Wesley Brooks
doaj   +1 more source