Results 21 to 30 of about 7,527 (184)

Cell Therapy Approaches for Articular Cartilage Regeneration

Organogenesis, 2023
Articular cartilage is a common cartilage type found in a multitude of joints throughout the human body. However, cartilage is limited in its regenerative capacity.
Meagan J. Makarczyk
doaj   +1 more source

Clinical Outcome 3 Years After Autologous Chondrocyte Implantation Does Not Correlate With the Expression of a Predefined Gene Marker Set in Chondrocytes Prior to Implantation but Is Associated With Critical Signaling Pathways

Orthopaedic Journal of Sports Medicine, 2014
Background: There is a need for tools to predict the chondrogenic potency of autologous cells for cartilage repair. Purpose: To evaluate previously proposed chondrogenic biomarkers and to identify new biomarkers in the chondrocyte transcriptome capable ...
Johan Stenberg PhD, Tommy S. de Windt MD, Jane Synnergren PhD, Lars Hynsjö PhD, Josefine van der Lee MS, Daniel B.F. Saris Prof., Mats Brittberg Prof., Lars Peterson Prof., Anders Lindahl Prof.   +8 more
doaj   +1 more source

Autologous chondrocyte implantation for rheumatoid arthritis of the knee: a case report

Journal of Medical Case Reports, 2009
Introduction Although pharmacologic treatment remains the mainstay for treating rheumatoid arthritis, there is an increasing need for a method that biologically regenerates arthritic knee lesions as patient longevity continually increases.
Kim Seok-Jung, Chang Cheong-Ho, Suh Dong-Sam, Ha Hyun-Kwon, Suhl Kyung-Hwan   +4 more
doaj   +1 more source

Senolytic Peptide FOXO4-DRI Selectively Removes Senescent Cells From in vitro Expanded Human Chondrocytes

Frontiers in Bioengineering and Biotechnology, 2021
Autologous chondrocyte implantation (ACI) is a procedure used to treat articular cartilage injuries and prevent the onset of post-traumatic osteoarthritis.
Yuzhao Huang, Yuzhao Huang, Yuchen He, Meagan J. Makarcyzk, Meagan J. Makarcyzk, Hang Lin, Hang Lin, Hang Lin   +7 more
doaj   +1 more source

Cartilage Integration: Evaluation of the reasons for failure of integration during cartilage repair. A review [PDF]

European Cells & Materials, 2008
Articular cartilage is a challenging tissue to reconstruct or replace principally because of its avascular nature; large chondral lesions in the tissue do not spontaneously heal.
IM Khan, SJ Gilbert, SK Singhrao, VC Duance, CW Archer   +4 more
doaj   +3 more sources

A phase I/IIa clinical trial of third-generation autologous chondrocyte implantation (IK-01) for focal cartilage injury of the knee

Asia-Pacific Journal of Sports Medicine, Arthroscopy, Rehabilitation and Technology, 2022
Background/objective: The purpose of this study was to report the outcomes of a clinical trial conducted in Japan to assess the safety and effectiveness of third-generation autologous chondrocyte implantation (ACI) using IK-01 (CaReS™), which does not ...
Takehiko Matsushita, Tomoyuki Matsumoto, Daisuke Araki, Kanto Nagai, Yuichi Hoshino, Takahiro Niikura, Atsuhiko Kawamoto, Masahiro J. Go, Shin Kawamata, Masanori Fukushima, Ryosuke Kuroda   +10 more
doaj   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Spanish Experience in Autologous Chondrocyte Implantation [PDF]

The Open Orthopaedics Journal,, 2010
Introduction: The Spanish Ministry of Health commissioned the Galician Agency for Health Technology Assessment to monitor and follow-up Autologous Chondrocyte Implantation (ACI) used to treat chondral lesions of the knee in Spain.
Pérez-Cachafeiro, Santiago, Ruano-Raviña, Alberto, Couceiro-Follente, José, Benedí-Alcaine, Jose Antonio, Nebot-Sanchis, Ignacio, Casquete-Román, Ciriaco, Bello-Prats, Santiago, Couceiro-Sánchez, Gonzalo, Blanco, Francisco J.   +8 more
openaire   +2 more sources

Arthroscopic Chondral Defect Repair With Extracellular Matrix Scaffold and Bone Marrow Aspirate Concentrate

Arthroscopy Techniques, 2020
Chondral defects of the knee are prevalent and often encountered during arthroscopic procedures. Despite the limited healing potential of chondral defects, several treatment options have been proposed.
Iciar M. Dávila Castrodad, M.D., Samuel J. Mease, M.D., Erik Werheim, B.S., Vincent K. McInerney, M.D., Anthony J. Scillia, M.D.   +4 more
doaj   +1 more source

Biomimetic Gradient Hydrogels Regulate Osteochondral Regeneration Microenvironment Remodeling via Spatiotemporal Programming Engineering

Advanced Science, EarlyView.
Electric field‑driven continuous gradient hydrogel GHZF4 achieves spatiotemporal growth factor release, modulates immune microenvironment, angiogenesis and osteochondral differentiation. It realizes cell‑free functional osteochondral repair in rat/rabbit models, offering a promising biomimetic strategy for gradient tissue regeneration.
Xiaolian Niu, Shengzhao Xiao, Di Huang, Xuesong Wang, Yanwei Cao, Xiaodan Sun, Nicholas Dunne, Xiaoming Li   +7 more
wiley   +1 more source