Results 221 to 230 of about 1,031,034 (270)

NS1643 enhances the activity of T1019PfsX38 and Q1070X hERG channels associated with long QT syndrome type 2. [PDF]

Pflugers Arch
Al Salmani MK, Al Kharusi A, Al Rawahi M, Albarwani S.   +3 more
europepmc   +1 more source

Optimization of Pyrazole-Based Activators of Kv3.1. [PDF]

ACS Med Chem Lett
Spearing PK, Satpute Janve V, Romaine IM, Jayakodiarachchi N, Guttentag BW, Jana S, Kim K, Denton JS, Lindsley CW, Waterson AG.   +9 more
europepmc   +1 more source

Analysis of sodium self-inhibition of the epithelial sodium channel (ENaC) using classical and medium-throughput automated two-electrode voltage-clamp recordings. [PDF]

Pflugers Arch
Luján López KL, Furtwängler N, Frank CM, Althaus M, Rauh O.   +4 more
europepmc   +1 more source

Optimization of automated patch-clamp technique and comparative analysis with manual patch-clamp: A case study on the TRPV1 channel

Journal of Chinese Pharmaceutical Sciences
openaire   +1 more source

Studying mechanosensitive ion channels with an automated patch clamp [PDF]

European Biophysics Journal, 2014
Patch clamp electrophysiology is the main technique to study mechanosensitive ion channels (MSCs), however, conventional patch clamping is laborious and success and output depends on the skills of the operator. Even though automated patch systems solve these problems for other ion channels, they could not be applied to MSCs.
Armagan Kocer, Jan P Birkner, Christian Wahl-Schott   +2 more
exaly   +5 more sources

Automated whole-cell patch-clamp electrophysiology of neurons in vivo [PDF]

Nature Methods, 2012
Whole-cell patch-clamp electrophysiology of neurons is a gold-standard technique for high-fidelity analysis of the biophysical mechanisms of neural computation and pathology, but it requires great skill to perform. We have developed a robot that automatically performs patch clamping in vivo, algorithmically detecting cells by analyzing the temporal ...
Craig R Forest, Brian Y Chow, Suhasa B Kodandaramaiah   +2 more
exaly   +7 more sources

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A novel method for patch-clamp automation

Pflügers Archiv - European Journal of Physiology, 2006
An increasing demand of the pharmaceutical industry for automated electrophysiological stations for ion channel drug discovery has recently resulted in the development of several commercial platforms for secondary and safety screening of ion channel modulators.
D, Vasilyev, T, Merrill, A, Iwanow, J, Dunlop, M, Bowlby   +4 more
openaire   +2 more sources

Optogenetics and Optical Tools in Automated Patch Clamping

2020
Automated patch clamping (APC) has been used for almost two decades to increase the throughput of electrophysiological measurements, especially in preclinical safety screening of drug compounds. Typically, cells are suctioned onto holes in planar surfaces and a stronger subsequent suction allows access to a whole cell configuration for electrical ...
Kim, Boddum, Peder, Skafte-Pedersen, Jean-Francois, Rolland, Sandra, Wilson   +3 more
openaire   +2 more sources

The Chiptip: A Novel Tool for Automated Patch Clamp

Combinatorial Chemistry & High Throughput Screening, 2009
To facilitate automated patch clamp measurements of ion channels in cells, the development of an all-glass Chiptip pipette is reported that may be combined with the previously described Flip-the-Tip technology. A single measurement requires less than 50 cells, and the addition of drugs for screening can be limited to very low volumes down to 1 microL ...
Albrecht, Lepple-Wienhues, Dirck, Lassen, Alexander, Hümmer, Uwe, Czubayko, Martina, Knirsch, Andjelko, Golubovic   +5 more
openaire   +2 more sources