Results 241 to 250 of about 1,031,034 (270)
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Automated Patch-Clamp Methods for the hERG Cardiac Potassium Channel
2017The human Ether-a-go-go Related Gene (hERG) product has been identified as a central ion channel underlying both familial forms of elongated QT interval on the electrocardiogram and drug-induced elongation of the same QT segment. Indeed, reduced function of this potassium channel involved in the repolarization of the cardiac action potential can ...
Sylvie, Houtmann +4 more
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A device for automated control of pipette internal pressure for patch-clamp recording
Journal of Neuroscience Methods, 2003Formation of a high-resistance seal between the tip of a glass recording pipette and the membrane of the recorded cell is the crucial step in patch clamping, or whole cell recording with patch pipettes. Formation of the seal, and subsequent rupture of the membrane for whole cell recording, requires a specific sequence of changes in pipette internal ...
Philip M, Heyward, Michael T, Shipley
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Optimization of Cav1.2 screening with an automated planar patch clamp platform
Journal of Pharmacological and Toxicological Methods, 2009Ca(v)1.2 channels play an important role in shaping the cardiac action potential. Screening pharmaceutical compounds for Ca(v)1.2 block is very important in developing drugs without cardiac liability. Ca(v)1.2 screening has been traditionally done using fluorescence assays, but these assays have some limitations.
Bharathi, Balasubramanian +5 more
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The suitability of high throughput automated patch clamp for physiological applications
Journal of Physiology, 2022Stephan A. Pless +2 more
exaly
Use of automated patch clamp in cardiac safety assessment: past, present and future perspectives
Journal of Pharmacological and Toxicological Methods, 2021Damian C Bell, Bernard Fermini
exaly
Automated high-throughput patch-clamp techniques
Drug Discovery Today, 2004openaire +2 more sources
Pharmacology of P2X3 and P2X2/3 receptors: An automated patch clamp study
Biophysical Journal, 2023Sirtori, Elena +10 more
openaire +3 more sources