Results 41 to 50 of about 1,031,034 (270)
, 2021 Standard high throughput screening projects using automated patch-clamp instruments often fail to grasp essential details of the mechanism of action, such as binding/unbinding dynamics and modulation of gating.
Mátyás C. Földi (11492557) +6 more
core +1 more source
Automated Electrophysiology Makes the Pace for Cardiac Ion Channel Safety Screening
Frontiers in Pharmacology, 2011 The field of automated patch-clamp electrophysiology has emerged from the tension between the pharmaceutical industry’s need for high-throughput compound screening versus its need to be conservative due to regulatory requirements.
Clemens eMoeller, Harry eWitchel
doaj +1 more source
Automated Patch Clamp on mESC-Derived Cardiomyocytes for Cardiotoxicity Prediction [PDF]
SLAS Discovery, 2011 Cardiovascular side effects are critical in drug development and have frequently led to late-stage project terminations or even drug withdrawal from the market. Physiologically relevant and predictive assays for cardiotoxicity are hence strongly demanded by the pharmaceutical industry.
Sonja, Stoelzle +7 more
openaire +2 more sources
Automated patch clamp supports functional
Blood Red Cells & Iron: Hereditary xerocytosis (HX) is a dominantly inherited hemolytic anemia caused by gain-of-function mutations in the mechanosensitive ion channel PIEZO1.
Kian Haseli +6 more
doaj +1 more source
TraceSpecks: A Software for Automated Idealization of Noisy Patch-Clamp and Imaging Data [PDF]
Biophysical Journal, 2018 Abstract Experimental records of single molecules or ion channels from fluorescence microscopy and patch-clamp electrophysiology often include high-frequency noise and baseline fluctuations that are not generated by the system under investigation and have to be removed.
Shah, Syed Islamuddin +5 more
openaire +2 more sources
Frontiers in Pharmacology, 2011 Ion channels are essential in a wide range of cellular functions and their malfunction underlies many disease states making them important targets in drug discovery.
Sonja eStoelzle +6 more
doaj +1 more source
High-throughput electrophysiological assays for voltage gated ion channels using SyncroPatch 768PE. [PDF]
PLoS ONE, 2017 Ion channels regulate a variety of physiological processes and represent an important class of drug target. Among the many methods of studying ion channel function, patch clamp electrophysiology is considered the gold standard by providing the ultimate ...
Tianbo Li +5 more
doaj +1 more source
Automated Patch Clamp Meets High-Throughput Screening: 384 Cells Recorded in Parallel on a Planar Patch Clamp Module [PDF]
SLAS Technology, 2016 We have developed an automated patch clamp module for high-throughput ion channel screening, recording from 384 cells simultaneously. The module is incorporated into a laboratory pipetting robot and uses a 384-channel pipettor head for application of cells and compounds.
Alison, Obergrussberger +15 more
openaire +2 more sources
Advanced Engineering Materials, EarlyView.CT‐based finite element simulations combined with in situ X‐ray computed tomography are used to analyze insert pull‐out in nickel‐coated polymer foams. Despite variations in material parameters, deformation consistently concentrates within a narrow annular region around the insert.
Yannik Bautz +4 more
wiley +1 more source
Advanced Engineering Materials, EarlyView.More than 10 000 metal‐coated silicon MEMS cantilevers are fabricated and characterized to build a large‐scale experimental dataset spanning multiple vibrational modes. Machine learning algorithms are benchmarked to predict resonance frequency and quality factor, with ensemble based models achieving accuracy approaching experimental uncertainty.
Sina Zare Pakzad +8 more
wiley +1 more source