Results 81 to 90 of about 1,044,066 (265)

Optical electrophysiology for probing function and pharmacology of voltage-gated ion channels

eLife, 2016
Voltage-gated ion channels mediate electrical dynamics in excitable tissues and are an important class of drug targets. Channels can gate in sub-millisecond timescales, show complex manifolds of conformational states, and often show state-dependent ...
Hongkang Zhang, Elaine Reichert, Adam E Cohen   +2 more
doaj   +1 more source

An Extracellular Pore‑Targeting Peptide Defines a Designable Allosteric Site in TRPV2

Advanced Science, EarlyView.
Structure‐guided peptide engineering yields Depiv2, a highly potent and subtype‐selective TRPV2 inhibitor that binds to the extracellular pore and remodels it into a closed, non‐conductive state. Depiv2 suppresses pathological cardiac hypertrophy, establishing the TRPV2 outer pore as a designable interface for selective peptide modulation.
Aiqin Zhu, Hongkun Wang, Jiawei Wang, Xiaolu Liu, Aerziguli Aierken, Lizhen Xu, Ping Liang, Fan Yang   +7 more
wiley   +1 more source

Konzeption eines Patch-on-Chip-Systems für Wirkstofftests und Grundlagenforschung an vernetzten adhärenten Zellen [PDF]

, 2014
Die vorliegende Arbeit befasst sich mit der Konzeption eines neuartigen Patch-Clamp-Systems, mit dem das Verhalten von adhärent wachsenden Zellnetzwerken automatisiert untersucht werden kann.
Tautorat, Carsten (gnd: 1036273342)
core   +1 more source

Unveiling the Interfacial Dynamics of Crosslinked Biodegradable Polycaprolactone Solid Polymer Electrolytes and Li Metal During Lithium Plating and Stripping via Operando ATR‐FTIR Spectroscopy

Advanced Science, EarlyView.
This study presents a comprehensive interfacial characterization of the biodegradable PCL solid‐polymer electrolytes (SPEs) with Li metal, utilizing an advanced operando ATR‐FTIR spectroscopy. The investigation elucidates the interphase properties during Li plating/stripping in a zero‐excess cell configuration.
Jian‐Fen Wang, Matthias Weiling, Felix Pfeiffer, Marian C. Stan, Martin Winter, Masoud Baghernejad   +5 more
wiley   +1 more source

Insights into the structure and modulation of human TWIK-2

Nature Communications
The Tandem of pore domain in a Weak Inward Rectifying K+ channel 2 (TWIK-2; KCNK6) is a member of the Two-Pore Domain K + (K2P) channel family, which is associated with pulmonary hypertension, lung injury, and inflammation.
Qianqian Ma, Ciria C. Hernandez, Vikas Navratna, Arvind Kumar, Jaimin K. Rana, Jiameng Zong, Abraham Lee, Shyamal Mosalaganti   +7 more
doaj   +1 more source

A Kinetic Map of the Homomeric Voltage-Gated Potassium Channel (Kv) Family

Frontiers in Cellular Neuroscience, 2019
The voltage-gated potassium (Kv) channels, encoded by 40 genes, repolarize all electrically excitable cells, including plant, cardiac, and neuronal cells.
Rajnish Ranjan, Emmanuelle Logette, Emmanuelle Logette, Michela Marani, Mirjia Herzog, Mirjia Herzog, Valérie Tâche, Enrico Scantamburlo, Valérie Buchillier, Henry Markram, Henry Markram   +10 more
doaj   +1 more source

Automated multi-slice extracellular and patch-clamp experiments using the WinLTP data acquisition system with automated perfusion control

, 2012
WinLTP is a data acquisition program for studying long-term potentiation (LTP) and other aspects of synaptic function. Earlier versions of WinLTP (J. Neurosci.
Collingridge, Graham L, Fitzjohn, Stephen M, Anderson, William W   +2 more
core   +1 more source

Astrocytes Coordinate Neurovascular Coupling During Prolonged Sensory Demand via AQP4/TRPA1/BEST1/D‐Serine Signaling

Advanced Science, EarlyView.
Neuronal activation leads to astrocytic transient volume changes, activating transient receptor potential ankyrin 1 (TRPA1) channels, leading to Ca2+ influx. Activation of TRPA1 causes the release of D‐serine through BEST1. Finally, the augmented extracellular levels of D‐serine boost neuronal activity by binding GluN1‐containing NMDARs, leading to CBV
Kayoung Han, Minwoo Wendy Jang, Taeyoung Park, Ki Jung Kim, Victor James Drew, Sunpil Kim, Tai Young Kim, Mingu Gordon Park, Myeongju Kim, Seung Won Chung, Minah Suh, C. Justin Lee   +11 more
wiley   +1 more source

Vine‐Inspired Soft Robotics: Materials, Actuations, and Emerging Applications

Advanced Science, EarlyView.
Vine‐inspired robots grow from the tip, enabling navigation through confined spaces with minimal disturbance. This Review summarizes material and actuation strategies for vine‐inspired growth, key functions including steering, retraction, attachment, branching, and variable stiffness, and emerging applications spanning medical intervention, confined ...
Jiahao Wu, Xingyun Liu, Fangzhou Wang, Huili Ren, Chaojun Zhang, Ziyu Ren, Zunqi Liu, Jing Li   +7 more
wiley   +1 more source

Priming and testing silicon patch-clamp neurochips

, 2014
We report on the systematic and automated priming and testing of silicon planar patch-clamp chips after their assembly in Plexiglas packages and sterilization in an air plasma reactor.
Zhao, Ping, Py, Christophe, Denhoff, Michael W., Shiu, Matthew, Sabourin, Nicaulas, Weber, John   +5 more
core   +1 more source