Results 11 to 20 of about 1,007,449 (349)

Basal ryanodine receptor activity suppresses autophagic flux [PDF]

Biochemical Pharmacology, 2017
The inositol 1,4,5-trisphosphate receptors (IP3Rs) and intracellular Ca2+ signaling are critically involved in regulating different steps of autophagy, a lysosomal degradation pathway.
Bannai, Hiroko, Bootman, Martin D., Bultynck, Geert, Martinet, Wim, Mikoshiba, Katsuhiko, Nadif Kasri, Nael, Parys, Jan B., Pintelon, Isabel, Vervliet, Tim, Welkenhuyzen, Kirsten   +9 more
core   +5 more sources

Interleukin-4 affects microglial autophagic flux

Neural Regeneration Research, 2019
Interleukin-4 plays an important protective role in Alzheimer’s disease by regulating microglial phenotype, phagocytosis of amyloid-β, and secretion of anti-inflammatory and neurotrophic cytokines.
Run-Hong Tang, Rui-Qun Qi, Hua-Yan Liu
doaj   +3 more sources

Atg4b-dependent autophagic flux alleviates Huntington's disease progression. [PDF]

PLoS ONE, 2013
The accumulation of aggregated mutant huntingtin (mHtt) inclusion bodies is involved in Huntigton's disease (HD) progression. Medium sized-spiny neurons (MSNs) in the corpus striatum are highly vulnerable to mHtt aggregate accumulation and degeneration ...
Catia C Proenca, Natacha Stoehr, Mario Bernhard, Shanon Seger, Christel Genoud, Ana Roscic, Paolo Paganetti, Shanming Liu, Leon O Murphy, Rainer Kuhn, Tewis Bouwmeester, Ivan Galimberti   +11 more
doaj   +4 more sources

Eicosapentaenoic acid attenuates renal lipotoxicity by restoring autophagic flux

Autophagy, 2020
Recently, we identified a novel mechanism of lipotoxicity in the kidney proximal tubular cells (PTECs); lipid overload stimulates macroautophagy/autophagy for the renovation of plasma and organelle membranes to maintain the integrity of the PTECs ...
Takeshi Yamamoto, Yoshitsugu Takabatake, S. Minami, Shinsuke Sakai, Ryuta Fujimura, Atsushi Takahashi, Tomoko Namba-Hamano, J. Matsuda, Tomonori Kimura, I. Matsui, J. Kaimori, Hiroaki Takeda, Masatomo Takahashi, Yoshihiro Izumi, T. Bamba, T. Matsusaka, F. Niimura, M. Yanagita, Y. Isaka   +18 more
semanticscholar   +4 more sources

Neutrophil extracellular traps-triggered impaired autophagic flux via METTL3 underlies sepsis-associated acute lung injury

Cell Death Discovery, 2022
Neutrophil extracellular traps (NETs) assist pathogen clearance, while excessive NETs formation is associated with exacerbated inflammatory responses and tissue injury in acute lung injury (ALI)/acute respiratory distress syndrome (ARDS).
Mengdi Qu, Zhaoyuan Chen, Zhiyun Qiu, Ke Nan, Yang Wang, Yuxin Shi, Yuwen Shao, Ziwen Zhong, Shuainan Zhu, K. Guo, Wankun Chen, Xihua Lu, Zhiping Wang, Hao Zhang, C. Miao   +14 more
semanticscholar   +1 more source

Molecular imaging of the kinetics of hyperactivated ERK1/2-mediated autophagy during acquirement of chemoresistance

Cell Death and Disease, 2021
Alterations in key kinases and signaling pathways can fine-tune autophagic flux to promote the development of chemoresistance. Despite empirical evidences of strong association between enhanced autophagic flux with acquired chemoresistance, it is still ...
Aniketh Bishnu, Pratham Phadte, Ajit Dhadve, Asmita Sakpal, Bharat Rekhi, Pritha Ray   +5 more
doaj   +1 more source

PPARα Inhibits Astrocyte Inflammation Activation by Restoring Autophagic Flux after Transient Brain Ischemia

Biomedicines, 2023
Astrocyte inflammation activation is an important cause that hinders the recovery of motor function after cerebral ischemia. However, its molecular mechanism has not yet been clearly clarified.
Doudou Luo, Wenxuan Ye, Ling Chen, Xiaoqian Yuan, Yali Zhang, Caixia Chen, Xin Jin, Yu Zhou   +7 more
doaj   +1 more source

RIPK1-RIPK3 mediates myocardial fibrosis in type 2 diabetes mellitus by impairing autophagic flux of cardiac fibroblasts

Cell Death and Disease, 2022
Receptor-interacting protein kinase 1 (RIPK1) and 3 (RIPK3) are critical regulators of programmed necrosis or necroptosis. However, the role of the RIPK1/RIPK3 signaling pathway in myocardial fibrosis and related diabetic cardiomyopathy is still unclear.
S. Qiao, Lei Hong, Yongming Zhu, J. Zha, An Wang, Jia Qiu, Wei Li, Chen Wang, Jianzhong An, Huiling Zhang   +9 more
semanticscholar   +1 more source

Robust LC3B lipidation analysis by precisely adjusting autophagic flux

Scientific Reports, 2022
Autophagic flux can be quantified based on the accumulation of lipidated LC3B in the presence of late-stage autophagy inhibitors. This method has been widely applied to identify novel compounds that activate autophagy.
Martina P. Liebl, S. Meister, Lisa Frey, Kristina Hendrich, A. Klemmer, Bettina Wohlfart, Christopher Untucht, Judith Nuber, C. Pohl, V. Lakics   +9 more
semanticscholar   +1 more source

Surgical procedures suppress autophagic flux in the kidney [PDF]

Cell Death & Disease, 2021
AbstractMany surgical models are used to study kidney and other diseases in mice, yet the effects of the surgical procedure itself on the kidney and other tissues have not been elucidated. In the present study, we found that both sham surgery and unilateral nephrectomy (UNX), which is used as a model of renal compensatory hypertrophy, in mice resulted ...
Carolyn N. Brown, Daniel Atwood, Deepak Pokhrel, Sara J. Holditch, Christopher Altmann, Nataliya I. Skrypnyk, Jennifer Bourne, Jelena Klawitter, Judith Blaine, Sarah Faubel, Andrew Thorburn, Charles L. Edelstein   +11 more
openaire   +3 more sources