Results 21 to 30 of about 1,007,449 (349)

Conessine Interferes with Oxidative Stress-Induced C2C12 Myoblast Cell Death through Inhibition of Autophagic Flux. [PDF]

PLoS ONE, 2016
Conessine, a steroidal alkaloid isolated from Holarrhena floribunda, has anti-malarial activity and interacts with the histamine H3 receptor. However, the cellular effects of conessine are poorly understood.
Hyunju Kim, Kang Il Lee, Minsu Jang, Sim Namkoong, Rackhyun Park, Hyunwoo Ju, Inho Choi, Won Keun Oh, Junsoo Park   +8 more
doaj   +1 more source

S-Nitrosylation of p62 Inhibits Autophagic Flux to Promote α-Synuclein Secretion and Spread in Parkinson's Disease and Lewy Body Dementia

Journal of Neuroscience, 2022
Dysregulation of autophagic pathways leads to accumulation of abnormal proteins and damaged organelles in many neurodegenerative disorders, including Parkinson's disease (PD) and Lewy body dementia (LBD).
Chang-ki Oh, Nima Dolatabadi, P. Cieplak, Maria T. Diaz-Meco, J. Moscat, J. Nolan, Tomohiro Nakamura, S. Lipton   +7 more
semanticscholar   +1 more source

Regulation of autophagic flux by CHIP [PDF]

Neuroscience Bulletin, 2015
Autophagy is a major degradation system which processes substrates through the steps of autophagosome formation, autophagosome-lysosome fusion, and substrate degradation. Aberrant autophagic flux is present in many pathological conditions including neurodegeneration and tumors. CHIP/STUB1, an E3 ligase, plays an important role in neurodegeneration.
Dongkai, Guo, Zheng, Ying, Hongfeng, Wang, Dong, Chen, Feng, Gao, Haigang, Ren, Guanghui, Wang   +6 more
openaire   +2 more sources

Restoration of Autophagic Flux Improves Endothelial Function in Diabetes Through Lowering Mitochondrial ROS-mediated eNOS Monomerization.

Diabetes, 2022
Endothelial nitric oxide synthase (eNOS) monomerization and uncoupling play crucial roles in mediating vascular dysfunction in diabetes mellitus although the underlying mechanisms are still incompletely understood.
Lei Zhao, Chenglin Zhang, Lei He, Qinghua Chen, Limei Liu, Lijing Kang, Jian Liu, Jiang-Yun Luo, L. Gou, Dan Qu, Wencong Song, C. Lau, Ho Ko, Vincent C. T. Mok, X. Tian, Li Wang, Yu Huang   +16 more
semanticscholar   +1 more source

Naringin protects human nucleus pulposus cells against TNF-α-induced inflammation, oxidative stress, and loss of cellular homeostasis by enhancing autophagic flux via AMPK/SIRT1 activation

Oxidative Medicine and Cellular Longevity, 2022
Activation of the proinflammatory‐associated cytokine, tumor necrosis factor-α (TNF-α), in nucleus pulposus (NP) cells is essential for the pathogenesis of intervertebral disc degeneration (IDD).
Renchang Chen, Shang-pu Gao, Huapeng Guan, Xin Zhang, Yuliang Gao, Youxiang Su, Yun Song, Yuehua Jiang, Nianhu Li   +8 more
semanticscholar   +1 more source

Hippocampal ornithine decarboxylase/spermidine pathway mediates H2S-alleviated cognitive impairment in diabetic rats: Involving enhancment of hippocampal autophagic flux

Journal of Advanced Research, 2021
Introduction: We have previously demonstrated the antagonistic role of hydrogen sulfide (H2S) in the cognitive dysfunction of streptozotocin (STZ)-induced diabetic rats.
Xuan Kang, Cheng Li, Yan Xie, Ling-Li He, Fan Xiao, Ke-Bin Zhan, Yi-Yun Tang, Xiang Li, Xiao-Qing Tang   +8 more
doaj   +1 more source

Endothelial autophagic flux hampers atherosclerotic lesion development [PDF]

Autophagy, 2018
Blood flowing in arteries generates shear forces at the surface of the vascular endothelium that control its anti-atherogenic properties. However, due to the architecture of the vascular tree, these shear forces are heterogeneous and atherosclerotic plaques develop preferentially in areas where shear is low or disturbed. Here we review our recent study
Kheloufi, Marouane, Vion, Anne-Clémence, Hammoutene, Adel, Poisson, Johanne, Lasselin, Juliette, Devue, Cecile, Pic, Isabelle, Dupont, Nicolas, Busse, Johanna, Stark, Konstantin, Lafaurie-Janvore, Julie, Barakat, Abdul, Loyer, Xavier, Souyri, Michele, Viollet, Benoit, Julia, Pierre, Tedgui, Alain, Codogno, Patrice, Boulanger, Chantal, Rautou, Pierre-Emmanuel   +19 more
openaire   +4 more sources

The CAGE–MiR-181b-5p–S1PR1 Axis Regulates Anticancer Drug Resistance and Autophagy in Gastric Cancer Cells

Frontiers in Cell and Developmental Biology, 2021
Cancer-associated gene (CAGE), a cancer/testis antigen, has been known to promote anticancer drug resistance. Since the underlying mechanisms of CAGE-promoted anticancer drug resistance are poorly understood, we established Anticancer drug-resistant ...
Minjeong Yeon, Youngmi Kim, Deepak Pathak, Eunju Kwon, Dong Young Kim, Myeong Seon Jeong, Myeong Seon Jeong, Hyun Suk Jung, Dooil Jeoung   +8 more
doaj   +1 more source

Miz1 is required to maintain autophagic flux [PDF]

Nature Communications, 2013
Miz1 is a zinc finger protein that regulates the expression of cell cycle inhibitors as part of a complex with Myc. Cell cycle-independent functions of Miz1 are poorly understood. Here we use a Nestin-Cre transgene to delete an essential domain of Miz1 in the central nervous system (Miz1(ΔPOZNes)).
Elmar, Wolf, Anneli, Gebhardt, Daisuke, Kawauchi, Susanne, Walz, Björn, von Eyss, Nicole, Wagner, Christoph, Renninger, Georg, Krohne, Esther, Asan, Martine F, Roussel, Martin, Eilers   +10 more
openaire   +2 more sources

Determination of the autophagic flux in murine and human peripheral blood mononuclear cells

Frontiers in Cell and Developmental Biology, 2023
The autophagy lysosomal system (ALS) is crucial for cellular homeostasis, contributing to maintain whole body health and alterations are associated with diseases like cancer or cardiovascular diseases.
Sophia Walter, Sophia Walter, Tobias Jung, Catrin Herpich, Catrin Herpich, Catrin Herpich, Kristina Norman, Kristina Norman, Kristina Norman, Kristina Norman, Olga Pivovarova-Ramich, Olga Pivovarova-Ramich, Olga Pivovarova-Ramich, Christiane Ott, Christiane Ott   +14 more
doaj   +1 more source