Results 31 to 40 of about 1,007,449 (349)

Activation of Autophagic Flux Maintains Mitochondrial Homeostasis during Cardiac Ischemia/Reperfusion Injury

Cells, 2022
Reperfusion injury after extended ischemia accounts for approximately 50% of myocardial infarct size, and there is no standard therapy. HDAC inhibition reduces infarct size and enhances cardiomyocyte autophagy and PGC1α-mediated mitochondrial biogenesis ...
Li-Ying He, Y-W Chu, Jing Yang, Jin He, Y. Hua, Yunxi Chen, G. Benavides, G. Rowe, Lufang Zhou, S. Ballinger, V. Darley-Usmar, M. Young, S. Prabhu, P. Sethu, Yi Zhou, Cheng Zhang, Min Xie   +16 more
semanticscholar   +1 more source

LncRNA MALAT1 promotes gastric cancer progression via inhibiting autophagic flux and inducing fibroblast activation

Cell Death and Disease, 2021
Autophagy defection contributes to inflammation dysregulation, which plays an important role in gastric cancer (GC) progression. Various studies have demonstrated that long noncoding RNA could function as novel regulators of autophagy.
Zhen-qiang Wang, Xinjing Wang, Tianqi Zhang, Liping Su, Bing-ya Liu, Zhenggang Zhu, Chen Li   +6 more
semanticscholar   +1 more source

MTOR regulates autophagic flux in the glomerulus [PDF]

Autophagy, 2012
Sirolimus (rapamycin), an inhibitor of the mechanistic target of rapamycin (MTOR), was originally proposed as an immunosuppressant to prevent rejection of solid organ transplants. There were expectations that MTOR inhibitors would replace nephrotoxic calcineurin inhibitors (CNIs). Despite its potential advantages, evidence that sirolimus causes de novo
Davide P, Cinà, Tuncer, Onay, Aarti, Paltoo, Chengjin, Li, Yoshiro, Maezawa, Javier, De Arteaga, Andrea, Jurisicova, Susan E, Quaggin   +7 more
openaire   +2 more sources

Broad-Spectrum HDAC Inhibitors Promote Autophagy through FOXO Transcription Factors in Neuroblastoma

Cells, 2021
Depending on context and tumor stage, deregulation of autophagy can either suppress tumorigenesis or promote chemoresistance and tumor survival. Histone deacetylases (HDACs) can modulate autophagy; however, the exact mechanisms are not fully understood ...
Katharina Körholz, Johannes Ridinger, Damir Krunic, Sara Najafi, Xenia F. Gerloff, Karen Frese, Benjamin Meder, Heike Peterziel, Silvia Vega-Rubin-de-Celis, Olaf Witt, Ina Oehme   +10 more
doaj   +1 more source

Inhibition of PDE1-B by Vinpocetine Regulates Microglial Exosomes and Polarization Through Enhancing Autophagic Flux for Neuroprotection Against Ischemic Stroke

Frontiers in Cell and Developmental Biology, 2021
Exosomes contribute to cell–cell communications. Emerging evidence has shown that microglial exosomes may play crucial role in regulation of neuronal functions under ischemic conditions.
Jiankun Zang, Yousheng Wu, Xuanlin Su, Tianyuan Zhang, Xionglin Tang, Dan Ma, Yufeng Li, Yanfang Liu, Zean Weng, Xuanzhuo Liu, C. Tsang, Anding Xu, Dan Lu   +12 more
semanticscholar   +1 more source

Small fluorescent molecules for monitoring autophagic flux [PDF]

FEBS Letters, 2018
We have developed two types of fluorescent probes, DALGreen and DAPGreen, for monitoring autophagy, that exhibit fluorescence upon being incorporated into autophagosomes. DALGreen enhances its fluorescence at acidic pH, which is favorable for monitoring late‐phase autophagy, whereas DAPGreen remains fluorescent with almost constant brightness during ...
Iwashita, Hidefumi, Sakurai, Hajime Tajima, Nagahora, Noriyoshi, Ishiyama, Munetaka, Shioji, Kosei, Sasamoto, Kazumi, Okuma, Kentaro, Shimizu, Shigeomi, Ueno, Yuichiro   +8 more
openaire   +2 more sources

Intracellular cholesterol transport inhibition Impairs autophagy flux by decreasing autophagosome–lysosome fusion

Cell Communication and Signaling, 2022
Background Autophagy is an intracellular degradation process crucial for homeostasis. During autophagy, a double-membrane autophagosome fuses with lysosome through SNARE machinery STX17 to form autolysosome for degradation of damaged organelle.
Yunash Maharjan, Raghbendra Kumar Dutta, Jinbae Son, Xiaofan Wei, Channy Park, Hyug Moo Kwon, Raekil Park   +6 more
doaj   +1 more source

Outer membrane vesicles produced by pathogenic strains of Escherichia coli block autophagic flux and exacerbate inflammasome activation

bioRxiv, 2021
Escherichia coli strains are responsible for a majority of human extra-intestinal infections, resulting in huge direct medical and social costs. We had previously shown that HlyF encoded by a large virulence plasmid harbored by pathogenic E.
L. David, F. Taieb, M. Pénary, P. Bordignon, R. Planès, Salimata Bagayoko, Valérie Duplan-Eche, E. Meunier, É. Oswald   +8 more
semanticscholar   +1 more source

Using enhanced-mitophagy to measure autophagic flux [PDF]

Methods, 2015
Macroautophagy (hereafter termed autophagy) is a cellular membrane-trafficking process that functions to deliver cytoplasmic constituents to lysosomes for degradation. Autophagy operates at basal levels to turn over damaged and misfolded proteins and it is the only process for the turnover of organelles.
Baudot, Alice, Haller, Martina, Mrschtik, Michaela, Tait, Stephen, Ryan, Kevin   +4 more
openaire   +2 more sources

Experimental diabetes exacerbates autophagic flux impairment during myocardial I/R injury through calpain‐mediated cleavage of Atg5/LAMP2

Journal of Cellular and Molecular Medicine, 2022
To explore the role of autophagic flux in the increased susceptibility of the experimental diabetic heart to ischaemia‐reperfusion (I/R) injury, we established STZ‐induced diabetic mice and performed I/R.
Lichun Guan, Ziqing Yu, Zhi-Ping Che, Hang Zhang, Yong Yu, Dicheng Yang, Dewei Qian, Ruizhen Chen, Min Yu   +8 more
semanticscholar   +1 more source