Results 161 to 170 of about 77,404 (202)
Dual role of autophagy in gouty arthritis (GA): molecular mechanisms and therapeutic potential. [PDF]
Front ImmunolQadri M.
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Autophagy in Alzheimer's Disease: Mechanisms, Clinical Trials, and Horizons.
Neurodegener DisTshimbombu TN +8 more
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Journal of Molecular Biology, 2020 Macroautophagy is a conserved catabolic process observed in all eukaryotic cells, during which selected cellular components are transported to and broken down within lysosomes. The process starts with the capture of unnecessary material into autophagosomes, which is followed by autophagosome-lysosome fusion to generate autolysosomes that degrade the ...
Péter Lőrincz, Gabor Juhasz
exaly +5 more sources
The Role of Atg Proteins in Autophagosome Formation
Annual Review of Cell and Developmental Biology, 2011 Macroautophagy is mediated by a unique organelle, the autophagosome, which encloses a portion of cytoplasm for delivery to the lysosome. Autophagosome formation is dynamically regulated by starvation and other stresses and involves complicated membrane ...
Tamotsu Yoshimori +2 more
exaly +2 more sources
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2021
Autophagy is a major intracellular degradation/recycling system that ubiquitously exists in eukaryotic cells. Autophagy contributes to the turnover of cellular components through engulfing portions of the cytoplasm or organelles and delivering them to the lysosomes/vacuole to be degraded.
Jingjing, Ye, Ming, Zheng
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Autophagy is a major intracellular degradation/recycling system that ubiquitously exists in eukaryotic cells. Autophagy contributes to the turnover of cellular components through engulfing portions of the cytoplasm or organelles and delivering them to the lysosomes/vacuole to be degraded.
Jingjing, Ye, Ming, Zheng
openaire +2 more sources
Autophagosome Biogenesis Machinery
Journal of Molecular Biology, 2020We review current knowledge of the process of autophagosome formation with special emphasis on the very early steps: turning on the autophagy pathway, assembling the autophagy machinery, and building the autophagosome. The pathway is remarkably well coordinated spatially and temporally, and it shows broad conservation across species and cell types ...
Simon A. Walker, Nicholas T. Ktistakis
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Autophagosomes and human diseases
The International Journal of Biochemistry & Cell Biology, 2011The autophagosome is a double-membrane bound compartment that initiates macroautophagy, a degradative pathway for cytoplasmic material terminating in the lysosomal compartment. The discovery of ATG genes involved in the formation of autophagosomes has greatly increased our understanding of the molecular basis of macroautophagy, and its role in cell ...
Isabelle, Beau +2 more
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Actin shapes the autophagosome
Nature Cell Biology, 2015Compared with most intracellular vesicles, the autophagosome is formed by an unusual event of vesicle budding involving an elusive sequence of membrane expansions that ends with a double membrane vesicle. It is now shown that actin polymerization inside the forming autophagosome is a driving force for the expansion and assembly of a functional ...
Petter, Holland, Anne, Simonsen
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The origin of the autophagosomal membrane
Nature Cell Biology, 2010Macroautophagy is initiated by the formation of the phagophore (also called the isolation membrane). This membrane can both selectively and non-selectively engulf cytosolic components, grow and close around the sequestered components and then deliver them to a degradative organelle, the lysosome.
Sharon A, Tooze, Tamotsu, Yoshimori
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