Results 1 to 10 of about 4,000 (206)

Approaching autozygosity in a small pedigree of Gochu Asturcelta pigs [PDF]

Genetics Selection Evolution, 2023
Background In spite of the availability of single nucleotide polymorphism (SNP) array data, differentiation between observed homozygosity and that caused by mating between relatives (autozygosity) introduces major difficulties.
Katherine D. Arias, Juan Pablo Gutiérrez, Iván Fernández, Isabel Álvarez, Félix Goyache   +4 more
doaj   +6 more sources

Relationships between estimated autozygosity and complex traits in the UK Biobank. [PDF]

PLoS Genetics, 2018
Inbreeding increases the risk of certain Mendelian disorders in humans but may also reduce fitness through its effects on complex traits and diseases. Such inbreeding depression is thought to occur due to increased homozygosity at causal variants that ...
Emma C Johnson, Luke M Evans, Matthew C Keller   +2 more
doaj   +11 more sources

Associations of genome-wide and regional autozygosity with 96 complex traits in old order Amish [PDF]

BMC Genomics, 2023
Background: Autozygosity, the proportion of the genome that is homozygous by descent, has been associated with variation in multiple health-related traits impacting evolutionary fitness. Autozygosity (FROH) is typically measured from runs of homozygosity
Megan T. Lynch, Kristin A. Maloney, Huichun Xu, James A. Perry, Regeneron Genetics Center, Alan R. Shuldiner, Braxton D. Mitchell   +6 more
doaj   +3 more sources

Runs of homozygosity implicate autozygosity as a schizophrenia risk factor. [PDF]

PLoS Genetics, 2012
Autozygosity occurs when two chromosomal segments that are identical from a common ancestor are inherited from each parent. This occurs at high rates in the offspring of mates who are closely related (inbreeding), but also occurs at lower levels among ...
Matthew C Keller, Matthew A Simonson, Stephan Ripke, Ben M Neale, Pablo V Gejman, Daniel P Howrigan, Sang Hong Lee, Todd Lencz, Douglas F Levinson, Patrick F Sullivan, Schizophrenia Psychiatric Genome-Wide Association Study Consortium   +10 more
doaj   +16 more sources

Patterns of reproduction and autozygosity distinguish the breeding from nonbreeding gray wolves of Yellowstone National Park. [PDF]

J Hered, 2023
For species of management concern, accurate estimates of inbreeding and associated consequences on reproduction are crucial for predicting their future viability.
vonHoldt BM, DeCandia AL, Cassidy KA, Stahler EE, Sinsheimer JS, Smith DW, Stahler DR.   +6 more
europepmc   +2 more sources

Widespread recessive effects on common diseases in a cohort of 44,000 British Pakistanis and Bangladeshis with high autozygosity. [PDF]

Am J Hum Genet
Genetic association studies have focused on testing additive models in cohorts with European ancestry. Little is known about recessive effects on common diseases, specifically for non-European ancestry. Genes & Health is a cohort of British Pakistani and
Heng TH, Walter K, Huang QQ, Karjalainen J, Daly MJ, Heyne HO, FinnGen, Malawsky DS, Kalantzis G, Genes & Health Research Team, Finer S, van Heel DA, Martin HC.   +12 more
europepmc   +4 more sources

Regional autozygosity association with albumin-to-creatinine ratio reveals a novel FTO region in an Indigenous Australian population. [PDF]

Eur J Hum Genet
The genetic distinctiveness of Indigenous Australian populations is well established, yet the Tiwi population remains underrepresented in genetic research.
Arunachalam V, Tran KN, Hoy W, Lea RA, Nagaraj SH.   +4 more
europepmc   +2 more sources

Autozygosity Mapping by Genome-wide Single Nucleotide Polymorphism Array Identifies a Novel Homozygous HR Mutation in a Consanguineous Family with Universal Hereditary Hair Loss

International Journal of Dermatology and Venerology, 2021
. Objective:. Isolated hereditary hypotrichosis is caused by mutations in as many as 11 different genes. The conventional mutation detection strategy consists of sequencing of individual candidate genes separately, a time consuming and costly approach ...
Sirous Zeinali, Leila Youssefian, Hassan Vahidnezhad, Amir Hossein Saeidian, Soheila Sotoudeh, Hamideh Bagherian, Jouni Uitto   +6 more
doaj   +2 more sources

Analysis of Autozygosity Using Whole-Genome Sequence Data of Full-Sib Families in Pikeperch (Sander lucioperca)

Frontiers in Genetics, 2022
Pikeperch (Sander lucioperca) has emerged as a high value species to the aquaculture industry. However, its farming techniques are at an early stage and its production is often performed without a selective breeding program, potentially leading to high ...
Lidia De los Ríos-Pérez, Tom Druet, Tom Goldammer, Tom Goldammer, Dörte Wittenburg   +4 more
doaj   +2 more sources

Recent Consanguinity and Outbred Autozygosity Are Associated With Increased Risk of Late-Onset Alzheimer’s Disease

Frontiers in Genetics, 2021
Prior work in late-onset Alzheimer’s disease (LOAD) has resulted in discrepant findings as to whether recent consanguinity and outbred autozygosity are associated with LOAD risk.
Valerio Napolioni, Marzia A. Scelsi, Raiyan R. Khan, Andre Altmann, Michael D. Greicius   +4 more
doaj   +2 more sources