Results 21 to 30 of about 4,000 (206)

Measures of autozygosity in decline: globalization, urbanization, and its implications for medical genetics.

PLoS Genetics, 2009
This research investigates the influence of demographic factors on human genetic sub-structure. In our discovery cohort, we show significant demographic trends for decreasing autozygosity associated with population variation in chronological age ...
Michael A Nalls, Javier Simon-Sanchez, J Raphael Gibbs, Coro Paisan-Ruiz, Jose Tomas Bras, Toshiko Tanaka, Mar Matarin, Sonja Scholz, Charles Weitz, Tamara B Harris, Luigi Ferrucci, John Hardy, Andrew B Singleton   +12 more
doaj   +5 more sources

Autozygosity mapping and time-to-spontaneous delivery in Norwegian parent-offspring trios [PDF]

Human Molecular Genetics, 2020
Parental genetic relatedness may lead to adverse health and fitness outcomes in the offspring. However, the degree to which it affects human delivery timing is unknown.
P. Solé-Navais, J. Bacelis, Ø. Helgeland, D. Modzelewska, M. Vaudel, Christopher Flatley, O. Andreassen, P. Njølstad, Louis J. Muglia, Stefan Johansson, Ge Zhang, B. Jacobsson   +11 more
semanticscholar   +7 more sources

Genomic Diversity as a Key Conservation Criterion: Proof‐of‐Concept From Mammalian Whole‐Genome Resequencing Data

Evolutionary Applications
Many international, national, state, and local organizations prioritize the ranking of threatened and endangered species to help direct conservation efforts. For example, the International Union for Conservation of Nature (IUCN) assesses the Green Status
Jong Yoon Jeon, Andrew N. Black, Erangi J. Heenkenda, Andrew J. Mularo, Gina F. Lamka, Safia Janjua, Anna Brüniche‐Olsen, John W. Bickham, Janna R. Willoughby, J. Andrew DeWoody   +9 more
doaj   +2 more sources

Autozygosity islands and ROH patterns in Nellore lineages: evidence of selection for functionally important traits

BMC Genomics, 2018
Background The aim of this study was to assess genome-wide autozygosity in a Nellore cattle population and to characterize ROH patterns and autozygosity islands that may have occurred due to selection within its lineages.
Elisa Peripolli, Julia Metzger, Marcos Vinícius Antunes de Lemos, Nedenia Bonvino Stafuzza, Sabrina Kluska, Bianca Ferreira Olivieri, Fabieli Louise Braga Feitosa, Mariana Piatto Berton, Fernando Brito Lopes, Danísio Prado Munari, Raysildo Barbosa Lôbo, Cláudio de Ulhoa Magnabosco, Fernando Di Croce, Jason Osterstock, Sue Denise, Angélica Simone Cravo Pereira, Fernando Baldi   +16 more
doaj   +2 more sources

Assessment of Autozygosity Derived From Runs of Homozygosity in Jinhua Pigs Disclosed by Sequencing Data

Frontiers in Genetics, 2019
Jinhua pig, a well-known Chinese indigenous breed, has evolved as a pig breed with excellent meat quality, greater disease resistance, and higher prolificacy.
Zhong Xu, Hao Sun, Zhe Zhang, Qingbo Zhao, Babatunde Shittu Olasege, Qiumeng Li, Yang Yue, Peipei Ma, Xiangzhe Zhang, Qishan Wang, Yuchun Pan, Yuchun Pan   +11 more
doaj   +2 more sources

Weighted likelihood inference of genomic autozygosity patterns in dense genotype data

BMC Genomics, 2017
Background Genomic regions of autozygosity (ROA) arise when an individual is homozygous for haplotypes inherited identical-by-descent from ancestors shared by both parents.
Alexandra Blant, Michelle Kwong, Zachary A. Szpiech, Trevor J. Pemberton   +3 more
doaj   +4 more sources

Global Autozygosity Is Associated with Cancer Risk, Mutational Signature and Prognosis [PDF]

Cancers, 2020
Simple Summary Global autozygosity in the form of runs of homozygosity is associated with various diseases. Heterozygosity ratio, an alternative measure of global autozygosity, is used to assess cancer risk in this study.
Limin Jiang, Fei Guo, Jijun Tang, S. Leng, S. Ness, Fei Ye, Huining Kang, D. Samuels, Yan Guo   +8 more
semanticscholar   +3 more sources

GENOME-WIDE DISTRIBUTION OF AUTOZYGOSITY ISLANDS IN SLOVAK WARMBLOOD HORSE

AGROFOR, 2020
The objective of this study was to estimate the distribution of autozygosity islands represented by homozygous segments (ROHs) in the genome of the Slovak Warmblood horse.
N. Moravčíková, R. Kasarda, M. Halo, A. Trakovická, Kristína Lehocká, Barbora Olšanská, J. Candrák   +6 more
semanticscholar   +3 more sources

Autozygosity in a Turkish family with scoliosis, blindness, and arachnodactyly syndrome [PDF]

Annals of Saudi Medicine, 2015
BACKGROUND AND OBJECTIVES: Blindness-scoliosis-arachnodactyly syndrome has been described in a family with parental consanguinity. We present the strategy employed to determine the gene locus responsible for the syndrome.
Seda Orenay-Boyacioglu, Mustafa Tekin, Munis Dundar   +2 more
doaj   +3 more sources

Exome sequencing and analysis of 44,028 British South Asians enriched for high autozygosity

medRxiv
Kim HI, DeBoever C, Walter K, Kalantzis G, Li C, Mozaffari SV, Kundu K, Jacobs BM, Mohammadi-Shemirani P, Musolf AM, Davitte JM, Aksit MA, Gafton J, Catalano K, Dawed AY, Graham RR, Guo B, Gupta N, Heng TH, Hunt KA, Iyer V, Langenberg C, Lassen FH, MacArthur DG, Maher ER, Maroteau C, Newman W, O’Rahilly S, Palmer DS, Popov I, Siddiqui M, Simpson M, Spreckley M, Wright J, Genes and Health Research Team, del Angel G, Petrovski S, Holzinger ER, Maranville JC, Addis L, Turner RM, Estrada K, Longerich S, Howson JMM, Jamshidi Y, Fauman EB, Miller MR, Diogo D, Trembath RC, Finer S, Martin HC, van Heel DA.   +51 more
europepmc   +2 more sources