Exploring the Relationships Between Autozygosity, Educational Attainment, and Cognitive Ability in a Contemporary, Trans-Ancestral American Sample. [PDF]
Behav Genet, 2022 Colbert SM +3 more
europepmc +2 more sources
EFNB3 Frameshift Variant in Weimaraner Dogs with a Condition Resembling a Congenital Mirror Movement Disorder. [PDF]
Mov DisordABSTRACT Background Congenital mirror movement disorders (CMMs) are clinically and genetically heterogeneous in human patients. CMMs have not been documented to occur spontaneously in animals. Objective The objective of this work was to document the first case of CMMs spontaneously occurring in Weimaraner dogs and to identify the underlying genetic ...
Schwarz C +11 more
europepmc +2 more sources
Human population structure, genome autozygosity and human health [PDF]
Genome Medicine, 2009 A major transition in human population structure is currently under way, moving from a historical metapopulation, comprising small and mainly rural endogamous communities, to large and increasingly panmictic urban populations. This process is predicted to increase outbreeding, and preliminary data from genomic surveys have helped to quantify the ...
Campbell, H. +3 more
openaire +5 more sources
Analysis of Homozygous-by-Descent (HBD) Segments for Purebred and Crossbred Pigs in Russia
Life, 2021 Intensive selection raises the efficiency of pig farming considerably, but it also promotes the accumulation of homozygosity, which can lead to an increase in inbreeding and the accumulation of deleterious variation.
Siroj Bakoev +7 more
doaj +1 more source
Evolutionary Applications, 2021 Knowledge on how adaptive evolution and human socio‐cultural and economic interests shaped livestock genomes particularly in sub‐Saharan Africa remains limited.
Getinet M. Tarekegn +11 more
doaj +1 more source
Genome‐wide autozygosity mapping in human populations [PDF]
Genetic Epidemiology, 2008 AbstractIndividuals are frequently observed to have long segments of uninterrupted sequences of homozygous markers. One of the major mechanisms that gives rise to such long homozygous segments is consanguineous marriages, where parents pass shared chromosomal segments to their child. Such chromosomal segments are also known as autozygous segments.
Shuang, Wang +3 more
openaire +2 more sources
The Relationship between Runs of Homozygosity and Inbreeding in Jersey Cattle under Selection. [PDF]
PLoS ONE, 2015 Inbreeding is often an inevitable outcome of strong directional artificial selection but on average it reduces population fitness with increased frequency of recessive deleterious alleles. Runs of homozygosity (ROH) representing genomic autozygosity that
Eui-Soo Kim +4 more
doaj +1 more source
Effect of artificial selection on runs of homozygosity in u.s. Holstein cattle. [PDF]
PLoS ONE, 2013 The intensive selection programs for milk made possible by mass artificial insemination increased the similarity among the genomes of North American (NA) Holsteins tremendously since the 1960s.
Eui-Soo Kim +8 more
doaj +1 more source
Frontiers in Genetics, 2020 There is a growing interest in standardizing gene-disease associations for the purpose of facilitating the proper classification of variants in the context of Mendelian diseases.
Sateesh Maddirevula +34 more
doaj +1 more source
Genetic Background and Inbreeding Depression in Romosinuano Cattle Breed in Mexico
Animals, 2021 The ultimate goal of genetic selection is to improve genetic progress by increasing favorable alleles in the population. However, with selection, homozygosity, and potentially harmful recessive alleles can accumulate, deteriorating genetic variability ...
Jorge Hidalgo +8 more
doaj +1 more source