Results 1 to 10 of about 6,248 (196)

Avenanthramide A potentiates Bim-mediated antineoplastic properties of 5-fluorouracil via targeting KDM4C/MIR17HG/GSK-3β negative feedback loop in colorectal cancer [PDF]

Acta Pharmaceutica Sinica B
Chemoresistance to 5-fluorouracil (5-FU) is a significant challenge in treating colorectal cancer (CRC). Novel combined regimens to thwart chemoresistance are therefore urgently needed.
Rong Fu, Zhangfeng Dou, Ning Li, Xueyuan Fan, Sajid Amin, Jinqi Zhang, Yuqing Wang, Zongwei Li, Zhuoyu Li, Peng Yang   +9 more
exaly   +4 more sources

Exploring Nutritional Quality and Bioactive Compounds in Oat Mediterranean Landraces and Cultivars [PDF]

Antioxidants
Oat (Avena sativa L.) is increasingly recognized as a functional food due to its unique profile of antioxidant and health-promoting compounds. Beyond its traditional role, our study reveals that Mediterranean landraces and related species harbour ...
Elena Prats, María Jesús Cañuelo, Carmen Tejero-Arroyo, Besma Sghaier-Hammami, Sofiene B. M. Hammami, Gracia Montilla-Bascon   +5 more
doaj   +2 more sources

Avenanthramide C From Oats Possibly Exerts Anti-Inflammatory Effects in Human Umbilical Vein Endothelial Cells. [PDF]

J Food Sci
ABSTRACT Chronic kidney disease (CKD) is associated with inflammation and cardiovascular complications and is partly exacerbated by the uremic toxin indoxyl sulfate (IS). IS is known to activate the aryl hydrocarbon receptor (AhR) to promote vascular inflammation.
Sasaki H, Masutomi H, Nagasawa H, Matsumoto Y, Okuma T, Otsuka T, Ishihara K, Suzuki Y, Ueda S.   +8 more
europepmc   +2 more sources

Avenanthramide C and chondroitin sulphate promote chondrogenic differentiation of adipose-derived mesenchymal stem cells [PDF]

Scientific Reports
Loss of functional chondrocytes contributes to cartilage degeneration. Autologous transplantation of adipose-derived mesenchymal stem cells (ASCs) offers a promising approach for cartilage repair; however, current differentiation protocols remain ...
Priscila Sun, Winston Lim, Shivatra C. Talchai, Veerapol Khemarangsan   +3 more
doaj   +2 more sources

Avenanthramide C mitigates cisplatin-induced hippocampal neurotoxicity and cognitive impairment in rats via suppression of neuroinflammation and neuronal apoptosis [PDF]

Frontiers in Pharmacology
IntroductionCisplatin (CP)-induced cognitive impairment, commonly referred to as chemobrain, affects a substantial proportion of patients with cancer and currently lacks an effective pharmacological treatment.
Maha Abdulrahman Aldubayan
doaj   +2 more sources

Avenanthramide C suppresses hypoxia-induced cyclooxygenase-2 expression through sirtuin1 activation in non-small-cell lung cancer cells

Animal Cells and Systems, 2020
Avenanthramide C (AVC), found mainly in oats, mediates anti-inflammatory activities by reducing the anti-inflammatory cytokine levels. This study investigated the effects of AVC on hypoxia-induced cyclooxygenase-2 (COX-2) expression in A549 cells.
Wonchung Lim
exaly   +2 more sources

Protective effects of avenanthramide-C against cisplatin-induced cardiotoxicity in rats by attenuating oxidative stress, inflammatory cytokines, and modulating p62–Keap1–Nrf2 pathway [PDF]

Frontiers in Pharmacology
IntroductionCisplatin (CIS) is widely recognized as a potent antineoplastic agent, especially effective for treating various solid tumors. Nevertheless, the pathological response it induces, alongside oxidative stress and inflammation from upstream ...
Maha Abdulrahman Aldubayan
doaj   +2 more sources

Oat Extract Avenanthramide-C Reverses Hippocampal Long-Term Potentiation Decline in Tg2576 Mice

Molecules, 2021
Memory deterioration in Alzheimer’s disease (AD) is thought to be underpinned by aberrant amyloid β (Aβ) accumulation, which contributes to synaptic plasticity impairment. Avenanthramide-C (Avn-C), a polyphenol compound found predominantly in oats, has a
Ming Wang
exaly   +3 more sources

Multidrug-Loaded Lipid Nanoemulsions for the Combinatorial Treatment of Cerebral Cavernous Malformation Disease [PDF]

Biomedicines, 2023
Cerebral cavernous malformation (CCM) or cavernoma is a major vascular disease of genetic origin, whose main phenotypes occur in the central nervous system, and is currently devoid of pharmacological therapeutic strategies.
Andrea Perrelli, Annalisa Bozza, Chiara Ferraris, Sara Osella, Andrea Moglia, Silvia Mioletti, Luigi Battaglia, Saverio Francesco Retta   +7 more
doaj   +2 more sources

Avenanthramide-C as Alzheimer’s Disease-Modifying Therapy: Early and Sustained Intervention Prevents Disease Progression in Mouse Models [PDF]

Cells
Most approved drugs for Alzheimer’s disease (AD) are indicated for early to moderate stages and primarily target amyloid-beta or neurotransmitter systems.
Alen Benhur Pravin Nathan, Areeba Aziz, Semyeong Choi, Seunghee Lee, Seyoung Jeon, Hyung-Seok Kim, Jonghyun Cho, Jihoon Jo   +7 more
doaj   +2 more sources