Avenanthramides as lipoxygenase inhibitors [PDF]
Heliyon, 2020 Avenanthramides (AVAs) present in oats are amides of anthranilic and cinnamic acids. AVAs are potent antioxidants and have anti-inflammatory properties.
Rikard Landberg +2 more
doaj +5 more sources
Exploring Nutritional Quality and Bioactive Compounds in Oat Mediterranean Landraces and Cultivars [PDF]
AntioxidantsOat (Avena sativa L.) is increasingly recognized as a functional food due to its unique profile of antioxidant and health-promoting compounds. Beyond its traditional role, our study reveals that Mediterranean landraces and related species harbour ...
Elena Prats +5 more
doaj +2 more sources
Avenanthramide C From Oats Possibly Exerts Anti-Inflammatory Effects in Human Umbilical Vein Endothelial Cells. [PDF]
J Food SciABSTRACT Chronic kidney disease (CKD) is associated with inflammation and cardiovascular complications and is partly exacerbated by the uremic toxin indoxyl sulfate (IS). IS is known to activate the aryl hydrocarbon receptor (AhR) to promote vascular inflammation.
Sasaki H +8 more
europepmc +2 more sources
Avenanthramide C and chondroitin sulphate promote chondrogenic differentiation of adipose-derived mesenchymal stem cells [PDF]
Scientific ReportsLoss of functional chondrocytes contributes to cartilage degeneration. Autologous transplantation of adipose-derived mesenchymal stem cells (ASCs) offers a promising approach for cartilage repair; however, current differentiation protocols remain ...
Priscila Sun +3 more
doaj +2 more sources
Journal of the International Society of Sports Nutrition, 2020 Background Avenanthramides (AVA) are a group of di-phenolic acids found only in oats and have shown antioxidant and anti-inflammatory effects in vitro and in vivo.
Tianou Zhang +8 more
doaj +2 more sources
Animal Cells and Systems, 2020 Avenanthramide C (AVC), found mainly in oats, mediates anti-inflammatory activities by reducing the anti-inflammatory cytokine levels. This study investigated the effects of AVC on hypoxia-induced cyclooxygenase-2 (COX-2) expression in A549 cells.
Wonchung Lim, Chounghun Kang
doaj +2 more sources
Avenanthramide C mitigates cisplatin-induced hippocampal neurotoxicity and cognitive impairment in rats via suppression of neuroinflammation and neuronal apoptosis [PDF]
Frontiers in PharmacologyIntroductionCisplatin (CP)-induced cognitive impairment, commonly referred to as chemobrain, affects a substantial proportion of patients with cancer and currently lacks an effective pharmacological treatment.
Maha Abdulrahman Aldubayan
doaj +2 more sources
Oat Extract Avenanthramide-C Reverses Hippocampal Long-Term Potentiation Decline in Tg2576 Mice
Molecules, 2021 Memory deterioration in Alzheimer’s disease (AD) is thought to be underpinned by aberrant amyloid β (Aβ) accumulation, which contributes to synaptic plasticity impairment. Avenanthramide-C (Avn-C), a polyphenol compound found predominantly in oats, has a
Yu-Young Lee +7 more
doaj +3 more sources
Diversity of avenanthramide content in wild and cultivated oats
Труды по прикладной ботанике, генетике и селекции, 2020 Background. Oat grains accumulate substantial amounts of various phenolic compounds that possess biological activity and have a potential to considerably increase health benefits of oats as a food.
S. Leonova +5 more
doaj +3 more sources
Protective effects of avenanthramide-C against cisplatin-induced cardiotoxicity in rats by attenuating oxidative stress, inflammatory cytokines, and modulating p62–Keap1–Nrf2 pathway [PDF]
Frontiers in PharmacologyIntroductionCisplatin (CIS) is widely recognized as a potent antineoplastic agent, especially effective for treating various solid tumors. Nevertheless, the pathological response it induces, alongside oxidative stress and inflammation from upstream ...
Maha Abdulrahman Aldubayan
doaj +2 more sources