Diversity of avenanthramide content in wild and cultivated oats
Труды по прикладной ботанике, генетике и селекции, 2020 Background. Oat grains accumulate substantial amounts of various phenolic compounds that possess biological activity and have a potential to considerably increase health benefits of oats as a food.
S. Leonova +5 more
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Avenanthramide-C as Alzheimer’s Disease-Modifying Therapy: Early and Sustained Intervention Prevents Disease Progression in Mouse Models [PDF]
CellsMost approved drugs for Alzheimer’s disease (AD) are indicated for early to moderate stages and primarily target amyloid-beta or neurotransmitter systems.
Alen Benhur Pravin Nathan +7 more
doaj +2 more sources
Avena sativa-derived avenanthramides suppress 12-lipoxygenase activity and downstream arachidonic acid metabolites in letrozole-induced PCOS rats [PDF]
Scientific ReportsPolycystic ovary syndrome (PCOS) implicates hormonal imbalance, ovulation disorders, metabolic disturbances, and chronic low-grade inflammation. In this study, we investigated the inflammation driven by 12-lipoxygenase (12-LOX)-mediated conversion of ...
Yara Walid +3 more
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Inhibitory Effects of Fermented Sprouted Oat Extracts on Oxidative Stress and Melanin Overproduction [PDF]
AntioxidantsHyperpigmentation occurs due to irregular secretion of melanin pigment in the skin. This can affect quality of life depending on its severity, so prevention and management are essential.
Hyeijin Cho +3 more
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Dihydroavenanthramide D Enhances Skin Barrier Function through Upregulation of Epidermal Tight Junction Expression [PDF]
Current Issues in Molecular BiologySkin barrier dysfunction and thin epidermis are hallmarks of sensitive skin and contribute to premature aging. Avenanthramides are the primary bioactive components of colloidal oatmeal, a commonly used treatment to enhance skin barrier function.
Jiye Park +5 more
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Avenanthramide-C ameliorate doxorubicin-induced hepatotoxicity via modulating Akt/GSK-3β and Wnt-4/β-Catenin pathways in male rats [PDF]
Frontiers in Molecular BiosciencesBackgroundDoxorubicin (DOX) drugs used in cancer treatment can cause various adverse effects, including hepatotoxicity. Natural-derived constituents have shown promising effects in alleviating chemotherapy-induced toxicities.
Maha Abdullah Alwaili +11 more
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Avenanthramide A potentiates Bim-mediated antineoplastic properties of 5-fluorouracil via targeting KDM4C/MIR17HG/GSK-3β negative feedback loop in colorectal cancer [PDF]
Acta Pharmaceutica Sinica BChemoresistance to 5-fluorouracil (5-FU) is a significant challenge in treating colorectal cancer (CRC). Novel combined regimens to thwart chemoresistance are therefore urgently needed.
Rong Fu +9 more
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Phenolic amides (avenanthramides) in oats - an update review. [PDF]
BioengineeredOats (Avena sativa L.) are one of the worldwide cereal crops. Avenanthramides (AVNs), the unique plant alkaloids of secondary metabolites found in oats, are nutritionally important for humans and animals. Numerous bioactivities of AVNs have been investigated and demonstrated in vivo and in vitro.
Xie X +8 more
europepmc +3 more sources
Synthesis of Avenanthramide C and Its Analogs Utilizing Classical Condensation, Saponification and Acidification [PDF]
ACS OmegaSe Myeong Choi +5 more
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Compared Inhibitory Activities of Tamoxifen and Avenanthramide B on Liver Esterase and Correlation Based on the Superimposed Structure Between Porcine and Human Liver Esterase [PDF]
International Journal of Molecular SciencesSeung-Hak Cho +2 more
exaly +2 more sources