Avenanthramide-C as Alzheimer’s Disease-Modifying Therapy: Early and Sustained Intervention Prevents Disease Progression in Mouse Models [PDF]
CellsMost approved drugs for Alzheimer’s disease (AD) are indicated for early to moderate stages and primarily target amyloid-beta or neurotransmitter systems.
Alen Benhur Pravin Nathan +7 more
doaj +3 more sources
Avenanthramide A potentiates Bim-mediated antineoplastic properties of 5-fluorouracil via targeting KDM4C/MIR17HG/GSK-3β negative feedback loop in colorectal cancer [PDF]
Acta Pharmaceutica Sinica BChemoresistance to 5-fluorouracil (5-FU) is a significant challenge in treating colorectal cancer (CRC). Novel combined regimens to thwart chemoresistance are therefore urgently needed.
Rong Fu +9 more
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Molecules, 2022 In this study, a method, based on an ultraperformance liquid chromatography coupled with high-field quadrupole orbitrap high-resolution mass spectrometry (UHPLC-QE-HF-HRMS) platform, was established for the trace determination of three major ...
Yuchao Feng +7 more
doaj +4 more sources
Compared Inhibitory Activities of Tamoxifen and Avenanthramide B on Liver Esterase and Correlation Based on the Superimposed Structure Between Porcine and Human Liver Esterase [PDF]
International Journal of Molecular SciencesExposure to tamoxifen can exert effects on the human liver, and esterases process prodrugs such as antibiotics and convert them to less toxic metabolites.
Sungbo Hwang +2 more
exaly +3 more sources
Brain Sciences, 2020 Avenanthramides are a group of phenolic alkaloids that have been shown to have anti-inflammatory, anti-oxidant, anti-atherogenic, and vasodilation effects.
Baoyuan Jin +4 more
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Avenanthramide C as a novel candidate to alleviate osteoarthritic pathogenesis [PDF]
BMB Reports, 2021 Osteoarthritis (OA) is a degenerative disorder that can result in the loss of articular cartilage. No effective treatment against OA is currently available. Thus, interest in natural health products to relieve OA symptoms is increasing. However, their qualities such as efficacy, toxicity, and mechanism are poorly understood.
Thanh-Tam Tran +6 more
openaire +4 more sources
Phytochemicals attenuating aberrant activation of β-catenin in cancer cells. [PDF]
PLoS ONE, 2012 Phytochemicals are a rich source of chemoprevention agents but their effects on modulating the Wnt/β-catenin signaling pathway have remained largely uninvestigated. Aberrantly activated Wnt signaling can result in the abnormal stabilization of β-catenin,
Dan Wang +3 more
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Effects of Cultivar on Phenolic Content and Antioxidant Activity of Naked Oat in China
Journal of Integrative Agriculture, 2014 To evaluate the effects of naked oat cultivars on their phenolic contents and antioxidant activities, the oat seeds from 21 different cultivars in China were collected, and their major nutritional components, compositions of polyphenols, and antioxidant ...
Li-tao TONG +5 more
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Avena sativa-derived avenanthramides suppress 12-lipoxygenase activity and downstream arachidonic acid metabolites in letrozole-induced PCOS rats [PDF]
Scientific ReportsPolycystic ovary syndrome (PCOS) implicates hormonal imbalance, ovulation disorders, metabolic disturbances, and chronic low-grade inflammation. In this study, we investigated the inflammation driven by 12-lipoxygenase (12-LOX)-mediated conversion of ...
Yara Walid +3 more
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Inhibitory Effects of Fermented Sprouted Oat Extracts on Oxidative Stress and Melanin Overproduction [PDF]
AntioxidantsHyperpigmentation occurs due to irregular secretion of melanin pigment in the skin. This can affect quality of life depending on its severity, so prevention and management are essential.
Hyeijin Cho +3 more
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