Results 61 to 70 of about 13,248 (184)

Klebsiella pneumoniae Carbapenemase-2 (KPC-2), Substitutions at Ambler Position Asp179, and Resistance to Ceftazidime-Avibactam: Unique Antibiotic-Resistant Phenotypes Emerge from β-Lactamase Protein Engineering

mBio, 2017
The emergence of Klebsiella pneumoniae carbapenemases (KPCs), β-lactamases that inactivate “last-line” antibiotics such as imipenem, represents a major challenge to contemporary antibiotic therapies.
Melissa D. Barnes, Marisa L. Winkler, Magdalena A. Taracila, Malcolm G. Page, Eric Desarbre, Barry N. Kreiswirth, Ryan K. Shields, Minh-Hong Nguyen, Cornelius Clancy, Brad Spellberg, Krisztina M. Papp-Wallace, Robert A. Bonomo   +11 more
doaj   +1 more source

Tissue and Serum Concentrations of Time‐Dependent Antibiotics in Infected Diabetic Foot Ulcers by Bolus or Continuous Administration: The Randomised DFIATIM Trial

Diabetes/Metabolism Research and Reviews, Volume 42, Issue 5, July 2026.
ABSTRACT Aims The clinical effectiveness of antibiotic (ATB) therapy in patients with infected diabetic foot ulcers (iDFUs) depends on achieving sufficient ATB concentrations in both serum and peripheral tissues. This study evaluated the availability and bactericidal activity of the time‐dependent ATBs—ceftazidime (CTZ) and amoxicillin/clavulanate (AMC)
Radka Jarošíková, Dominika Sojáková, Simona Antalová, Petr Tůma, Jan Polák, Michal Dubský, Andrea Němcová, Veronika Wosková, Pavol Beca, Istvan Modos, Jan Mareš, Jakub Mrázek, Chahrazed Mekadim, Markéta Skružná, Vladimíra Fejfarová   +14 more
wiley   +1 more source

Shifting Gears: The Future of Polymyxin Antibiotics

Antibiotics, 2019
The manuscripts contained in this special edition of Antibiotics represent a current review of the polymyxins as well as highlights from the 3rd International Polymyxin Conference, which was held in Madrid, Spain, 25 to 26 April 2018.
Justin R. Lenhard, Zackery P. Bulman, Brian T. Tsuji, Keith S. Kaye   +3 more
doaj   +1 more source

Global Distribution and Comparative Resistance Profiles of Escherichia coli Isolated From Bovine Meat and Meat Products: Evidence From Network Meta‐Analysis

Food Science &Nutrition, Volume 14, Issue 7, July 2026.
Schematic overview of the study and its principal findings. E. coli isolated from bovine meat and meat products was evaluated for antimicrobial resistance using Bayesian network meta‐analysis. The graphical abstract highlights the antimicrobial resistance ranking based on SUCRA, showing high resistance to penicillin, doxycycline, amoxicillin ...
Yaser Khorram Del, Peyman Mahmoudi, Amir Rashidi, Skala Idrees Hama Faraj, Jalal Rostamzadeh, Mohammad Razmkabir   +5 more
wiley   +1 more source

In vivo evolution of resistant subpopulations of KPC-producing Klebsiella pneumoniae during ceftazidime/avibactam treatment [PDF]

, 2018
Objectives: KPC-producing Klebsiella pneumoniae (KPC-Kp) represent a serious problem worldwide. Herein, we describe the evolution of ceftazidime/avibactam resistance by sequencing longitudinal clinical isolates from a patient with KPC-Kp bloodstream ...
Andrea Berlingeri, Sara Tedeschi, Paolo Gaibani, Giannella, Maddalena, Maddalena Giannella, Silvia Lidia Volpe, Tedeschi, Sara, Bartoletti, Michele, Erika Scaltriti, Berlingeri, Andrea, Lewis, Russell E., Michele Bartoletti, Caterina Campoli, Simone Ambretti, Gaibani, Paolo, Scaltriti, Erika, Campoli, Caterina, Francesco Cristini, Pongolini, Stefano, Volpe, Silvia Lidia, Cristini, Francesco, Ambretti, Simone, Stefano Pongolini, Russell E Lewis   +23 more
core   +1 more source

Infections Caused by Carbapenem-Resistant Enterobacteriaceae: An Update on Therapeutic Options

Frontiers in Microbiology, 2019
Carbapenems are considered as last-resort antibiotics for the treatment of infections caused by multidrug-resistant Gram-negative bacteria. With the increasing use of carbapenems in clinical practice, the emergence of carbapenem-resistant pathogens now ...
Chau-Chyun Sheu, Chau-Chyun Sheu, Ya-Ting Chang, Ya-Ting Chang, Shang-Yi Lin, Shang-Yi Lin, Yen-Hsu Chen, Yen-Hsu Chen, Yen-Hsu Chen, Po-Ren Hsueh, Po-Ren Hsueh   +10 more
doaj   +1 more source

Potent monoclonal antibodies against multidrug‐resistant hypervirulent Klebsiella pneumoniae

Interdisciplinary Medicine, Volume 4, Issue 4, July 2026.
A novel immunization strategy using a low‐virulence, multidrug‐resistant strain yields synergistic monoclonal antibodies against hypervirulent Klebsiella pneumoniae. These antibodies provide cross‐serotype protection through a dual‐mechanism of pathogen clearance and immunomodulation, offering a promising non‐antibiotic therapeutic for resistant ...
Yushan Jiang, Zhuolin Li, Yang Yang, Zihan He, Tyuji Hoshino, Vladislav Victorovich Khrustalev, Qing Zhu, Weiling Wu, Wei Zhao, Chenguang Shen, Shi Ouyang   +10 more
wiley   +1 more source

Rapid emergence of resistance to broad-spectrum direct antimicrobial activity of avibactam

Microbiology Spectrum
Avibactam (AVI) is a diazabicyclooctane (DBO) β-lactamase inhibitor used clinically in combination with ceftazidime. At concentrations higher than those typically achieved in vivo, it also has broad-spectrum direct antibacterial activity against ...
Michelle Nägeli, Shade Rodriguez, Aimee Iradukunda, Abigail L. Manson, Ashlee M. Earl, Thea Brennan-Krohn   +5 more
doaj   +1 more source

Identification and Genomic Analysis of the First Salmonella typhimurium Monophasic Variant 1,4,[5],12:i:‐ Isolate Harbouring a Chromosomally Integrated blaNDM‐5

Microbial Biotechnology, Volume 19, Issue 7, July 2026.
This study reports the first clinical isolate of the monophasic variant of Salmonella typhimurium (serotype 1,4,[5],12:i:‐) ST34 harbouring a chromosomally integrated blaNDM‐5. The ~11 kb resistance region is flanked by two directly oriented IS26 elements, forming an IS26‐composite transposon.
Shihan Zeng, Weilong Guo, Chengfeng Lin, Lianghui Peng, Jingjie Song   +4 more
wiley   +1 more source

Comparison of avibactam inhibition kinetics and avibactam active site interaction.

, 2015
athe chirality of avibactam tertiary N1 atombthe direction of N6 inwards towards the carbonyl carbon or away towards the solventcthe number of hydrogen bonds made with the oxygen atoms of the sulfatedhydrogen bonds formed with the nitrogen N6 of ...
Nikhil P. Krishnan (792291), Focco van den Akker (158508), Nhu Q. Nguyen (792292), Robert A. Bonomo (188763), Krisztina M. Papp-Wallace (792293)   +4 more
core   +1 more source