Results 121 to 130 of about 136,222 (342)

Enrichment of Hyaluronic Acid Binding Tumor Cells by Modulation of Selective Adhesion on Microgel Surfaces

open access: yesMacromolecular Rapid Communications, EarlyView.
We have developed a thermoresponsive microgel system for the selective enrichment of hyaluronic acid‐binding tumor cells. By modulating the adhesion on the microgel surface via temperature changes from 37°C to 30°C, we demonstrate a novel proof‐of‐principle for separating these tumor cell from white blood cells, which has potential applications in ...
Melanie Schmidt   +8 more
wiley   +1 more source

Exosome‐Based Cartilage‐Targeted Delivery System: Strategies and Applications

open access: yesSmall Science, EarlyView.
Construction strategies and applications of cartilage‐targeting exosomes. With the ageing of the global population, cartilage‐related diseases, such as osteoarthritis (OA) and intervertebral disc degeneration (IVDD), have increasingly become significant social problems threatening human health. Therefore, targeted therapy for cartilage is becoming more
Yao Wang   +3 more
wiley   +1 more source

Hydrogel Microspheres for Biomedical Applications

open access: yesSmall Science, EarlyView.
Hydrogel microspheres (HMs) play pivotal roles in biomedical applications, such as drug delivery, cell culture, regenerative medicine, wound healing, and tumor immunity. This review focuses on the latest findings to provide a more comprehensive understanding of HMs for biomedical applications.
Yingkang Huang   +11 more
wiley   +1 more source

Controlled method of reducing electrophoretic mobility of macromolecules, particles, or cells [PDF]

open access: yes, 1992
A method of reducing electrophoretic mobility of macromolecules, particles, cells, and other substances is provided which comprises interacting in a conventional electrophoretic separating procedure, the substances with a polymer-linked affinity compound
Vanalstine, James M.
core   +1 more source

Breaking the Low Concentration Barrier of Single‐Molecule Fluorescence Quantification to the Sub‐Picomolar Range

open access: yesSmall Methods, EarlyView.
Single‐molecule fluorescence detection can become highly challenging for diluted concentrations in the picomolar range. This “low concentration barrier” is broken into and achieves quantitative detection down to 0.1 pM. Introducing a diaphragm into a standard confocal microscope and implementing fluorescence lifetime correlation spectroscopy (FLCS ...
Malavika Kayyil Veedu, Jérôme Wenger
wiley   +1 more source

An Integrated Method to Evaluate the Treatment Efficacy and Immunogenicity of B‐Cell Acute Lymphoblastic Leukemia Therapeutic Enzyme Formulations

open access: yesSmall Methods, EarlyView.
This work presents an integrated set of methods to evaluate the efficacy of asparaginase formulations against B‐cell Acute Lymphoblastic Leukemia (ALL) in mice, including the establishment of an ALL murine model, an amino acid depletion study using high‐performance liquid chromatography (HPLC), and comprehensive assessment of antibody production ...
Julien Santelli   +6 more
wiley   +1 more source

Monoclonal antibodies to the cells of a regenerating limb [PDF]

open access: yes, 1985
Monoclonal antibodies were raised against differentiated cells, and blastemal cells from regenerating limbs of adult newts (Notophthalmus viridescens) and screened for specific staining by immunocytochemistry.
Brockes, Jeremy P., Kintner, Chris R.
core  

High‐Yield Assembly of Plasmon‐Coupled Nanodiamonds Using DNA Origami for Tuned Emission

open access: yesSmall Structures, EarlyView.
Engineering assemblies of single‐photon emitters and plasmonic elements with nanometer precision opens pathways for quantum sensing and photonics applications. A surface functionalization strategy is established for grafting DNA onto nanodiamonds, and their placement on DNA origami is optimized to achieve yields above 50%.
Niklas Hansen   +7 more
wiley   +1 more source

Combined Maxacalcitol/Betamethasone Butyrate Propionate Ointment Possesses Long‐Term Sustained Effects of Inducing Regulatory T Cells and Downregulating the Th17 Response, Even After Discontinuation of Its Application in Imiquimod‐Induced Psoriasiform Dermatitis

open access: yesThe Journal of Dermatology, EarlyView.
ABSTRACT We often experience sustained improvement, even after discontinuation of treatment in psoriasis lesions treated with topical vitamin D3 (VD3) or the combination of topical corticosteroids and VD3. However, the underlying mechanisms of these sustained effects remain unclear. We explored mechanisms for the sustained effects of maxacalcitol (MCT)
Teruo Shimizu   +7 more
wiley   +1 more source

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