Results 51 to 60 of about 136,222 (342)

A Peptide Nucleic Acid‐Functionalized Heterojunction Thin Film Transistor as a Scalable and Reusable Platform for Label‐Free Detection of MicroRNA

Advanced Functional Materials, EarlyView.
A miniaturized, label‐free, and enzyme‐free biosensor (miR‐TFT) enables direct electrical detection of microRNA (miRNA) with single‐nucleotide specificity and a detection limit of 0.6 fM. Built on a tri‐channel In2O3/ZnO heterojunction and functionalized with bespoke peptide nucleic acid (PNA) probes, the device is robust, reusable, and compatible with
Wejdan S. Al Ghamdi, Jorge Romero Domínguez, Erol Hasan, Temur Maksudov, Thomas D. Anthopoulos, Dana Alsulaiman   +5 more
wiley   +1 more source

Generating a High Valency Biotin Binder by Selecting Uniform Protein Assemblies via Crystallization

Crystals, 2019
Crystallization is a common practice in the purification process in small molecule synthesis while selecting the wanted product. For proteins it is rarely applied due to the methodological predicaments in obtaining crystals.
Orly Avraham, Yael Levi-Kalisman, Oded Livnah   +2 more
doaj   +1 more source

Aberrant lysosomal carbohydrate storage accompanies endocytic defects and neurodegeneration in Drosophila benchwarmer [PDF]

, 2005
Lysosomal storage is the most common cause of neurodegenerative brain disease in preadulthood. However, the underlying cellular mechanisms that lead to neuronal dysfunction are unknown.
Bellen, Hugo J, Callaerts, Patrick, Dermaut, Bart, Kania, Artur, Norga, Koenraad K, Pan, Hongling, Verstreken, Patrik, Zhou, Yi   +7 more
core   +3 more sources

Impact of Surface Functionalization on NV Quantum Properties: Implications for Biosensing with Fluorescent Nanodiamonds

Advanced Functional Materials, EarlyView.
Fluorescent nanodiamonds (fNDs) have emerged as an invaluable quantum sensing platform for biological and biochemical systems. This paper investigates the influence of common surface functionalization strategies for bioconjugation on the quantum properties of nitrogen vacancy (NV) centers in nanodiamonds.
Anja Sadžak, Iván Pérez, Mateja Guimarães, Lukas Spantzel, Fedor Jelezko, Michael Börsch, Anke Krueger   +6 more
wiley   +1 more source

Biotin-Functionalized Semiconducting Polymer in an Organic Field Effect Transistor and Application as a Biosensor

Sensors, 2012
This report presents biotin-functionalized semiconducting polymers that are based on fluorene and bithiophene co-polymers (F8T2). Also presented is the application of these polymers to an organic thin film transistor used as a biosensor.
Yong Suk Yang, Do-Hoon Hwang, Seong Hyun Kim, Sang Chul Lim, Zin-Sig Kim   +4 more
doaj   +1 more source

Highly sensitive electrochemical detection of biotin-avidin interaction on gold electrode modified with silver nanoparticles through bilayer assembly

Results in Chemistry, 2022
The trifunctional l-cysteine containing carboxylic acid, amine and thiol is chemisorbed on the gold electrode surface via the thiol groups to form the self-assembled monolayer.
Nirgaman Bage, Sadhana Kundu, Arpita Adhikari, Pradip Kar   +3 more
doaj   +1 more source

Detection of chromosome aberrations in metaphase and interphase tumor cells by in situ hybridization using chromosome-specific library probes [PDF]

, 1988
Chromosome aberrations in two glioma cell lines were analyzed using biotinylated DNA library probes that specifically decorate chromosomes 1, 4, 7, 18 and 22 from pter to qter.
A Al-Saadi, AG Knudson, B Trask, CD Bloomfield, D Pinkel, D. C. Ward, F Mitelman, G Rappold, GM Brodeur, GT Merlino, H Harris, H Yamazaki, HE McDermid, J Burns, J. Borden, JA Rey, JE Landegent, JR Shapiro, JS Waye, L Larizza, L Manuelidis, L Manuelidis, L Manuelidis, L. Manuelidis, LC Showe, M Schardin, MF Hansen, NB Atkin, P Lichter, P. Lichter, SH Bigner, SH Bigner, SH Bigner, T Boveri, T Cremer, T Cremer, T. Cremer, TA Libermann, W Henn   +38 more
core   +1 more source

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source

Ruthenium Complexes in Protein Science: Heading a New Generation of Therapeutic and Analytical Tools

Angewandte Chemie, EarlyView.
This review presents the latest advances in the development of ruthenium complexes within the field of protein science, highlighting their potential applications in biomedical and bioanalytical fields. Abstract Ruthenium complexes are distinguished by their versatile coordination chemistry, redox behaviors and photochemical properties. In recent years,
Liyan Zhang, Yun Chen, Sylvestre Bonnet
wiley   +2 more sources

Genetic and Imaging Approaches Reveal Pro-Inflammatory and Immunoregulatory Roles of Mast Cells in Contact Hypersensitivity

Frontiers in Immunology, 2018
Contact hypersensitivity (CHS) is a common T cell-mediated skin disease induced by epicutaneous sensitization to haptens. Mast cells (MCs) are widely deployed in the skin and can be activated during CHS responses to secrete diverse products, including ...
Nicolas Gaudenzio, Thomas Marichal, Thomas Marichal, Thomas Marichal, Stephen J. Galli, Stephen J. Galli, Stephen J. Galli, Laurent L. Reber   +7 more
doaj   +1 more source