Results 61 to 70 of about 12,985 (151)

Patterns of germline and somatic mutations in 16 genes associated with mismatch repair function or containing tandem repeat sequences

Cancer Medicine, 2020
Background We assumed that targeted next‐generation sequencing (NGS) of mismatch repair‐associated genes could improve the detection of driving mutations in colorectal cancers (CRC) with microsatellite instability (MSI) and microsatellite alterations at ...
Shih‐Ching Chang, Yuan‐Tzu Lan, Pei‐Ching Lin, Shung‐Haur Yang, Chien‐Hsing Lin, Wen‐Yi Liang, Wei‐Shone Chen, Jeng‐Kai Jiang, Jen‐Kou Lin   +8 more
doaj   +1 more source

APC and AXIN2 Are Promising Biomarker Candidates for the Early Detection of Adenomas and Hyperplastic Polyps

Cancer Informatics, 2020
Aberrant activation of the WNT/CTNNB1 pathway is notorious in colorectal cancer (CRC). Here, we demonstrate that the expression of specific and crucial WNT signaling pathway genes is linked to disease progression in colonic adenomatous (AP) and ...
Sama Rezasoltani, Mahrooyeh Hadizadeh, Mina Golmohammadi, Ehsan Nazemalhossini-Mojarad, Sina Salari, Hamid Rezvani, Hamid Asadzadeh-Aghdaei, Michael Ladomery, Chris Young, Fakhrosadat Anaraki, Sarah Almond, Maziar Ashrafian Bonab   +11 more
doaj   +1 more source

Genomic and epigenomic basis of breast invasive lobular carcinomas lacking CDH1 genetic alterations

npj Precision Oncology
CDH1 (E-cadherin) bi-allelic inactivation is the hallmark alteration of breast invasive lobular carcinoma (ILC), resulting in its discohesive phenotype. A subset of ILCs, however, lack CDH1 genetic/epigenetic inactivation, and their genetic underpinning ...
Higinio Dopeso, Andrea M. Gazzo, Fatemeh Derakhshan, David N. Brown, Pier Selenica, Sahar Jalali, Arnaud Da Cruz Paula, Antonio Marra, Edaise M. da Silva, Thais Basili, Laxmi Gusain, Lorraine Colon-Cartagena, Shirin Issa Bhaloo, Hunter Green, Chad Vanderbilt, Steffi Oesterreich, Anne Grabenstetter, M. Gabriela Kuba, Dara Ross, Dilip Giri, Hannah Y. Wen, Hong Zhang, Edi Brogi, Britta Weigelt, Fresia Pareja, Jorge S. Reis-Filho   +25 more
doaj   +1 more source

Expression pattern of \(\it Axin2\) during chicken development [PDF]

, 2016
Canonical \(\it Wnt\)-signalling is well understood and has been extensively described in many developmental processes. The regulation of this signaling pathway is of outstanding relevance for proper development of the vertebrate and invertebrate embryo.
Eckei, Gesa, Böing, Marion (Dr. rer. nat.), Brand-Saberi, Beate (Prof. Dr. rer. nat.), Morosan-Puopolo, Gabriela (Dr.)   +3 more
openaire  

miR-1275 Delivered via Mesenchymal Stem Cell-Derived Extracellular Vesicles Regulates ER-Phagy Through AXIN2 in Nucleus Pulposus Cells

Stem Cells International
Intervertebral disc degeneration (IDD) is a major contributor to low back pain, a prevalent and debilitating condition. Nucleus pulposus (NP) cells are essential for maintaining disc homeostasis, and their dysfunction plays a crucial role in IDD ...
Zhiwu Dong, Hailong Zhang, Wenwei Yang, Keliang Huang, Xin Zhang, Lianxiang Xing, Ying Zhang, Kewen Zhao   +7 more
doaj   +1 more source

miR-1246 regulates odontogenic differentiation of human dental pulp stem cells in an inflammatory microenvironment by targeting AXIN2: an in vitro study

Acta Odontologica Scandinavica
Objective: This study aimed to investigate the modulatory function of microRNA-1246 (miR-1246) in the odontogenic differentiation of human dental pulp stem cells (hDPSCs) under inflammatory conditions in vitro and to elucidate its underlying molecular ...
Shunying Wu, Yueyan Wang, Jiayi Yang
doaj   +1 more source

An aggregon in conductin/axin2 regulates Wnt/β-catenin signaling and holds potential for cancer therapy

Nature Communications, 2019
Polymerization of axin proteins is essential to suppress Wnt/β-catenin signaling. Here, the authors identify an aggregation site in the conductin/axin2 RGS domain that prevents its polymerization and show that a short peptide masking this aggregon ...
Dominic B. Bernkopf, Martina Brückner, Michel V. Hadjihannas, Jürgen Behrens   +3 more
doaj   +1 more source

Contrasting expression of canonical Wnt signaling reporters TOPGAL, BATGAL and Axin2(LacZ) during murine lung development and repair.

PLoS ONE, 2011
Canonical WNT signaling plays multiple roles in lung organogenesis and repair by regulating early progenitor cell fates: investigation has been enhanced by canonical Wnt reporter mice, TOPGAL, BATGAL and Axin2(LacZ).
Denise Al Alam, Melissa Green, Reza Tabatabai Irani, Sara Parsa, Soula Danopoulos, Frederic G Sala, Jonathan Branch, Elie El Agha, Caterina Tiozzo, Robert Voswinckel, Edwin C Jesudason, David Warburton, Saverio Bellusci   +12 more
doaj   +1 more source

Sika deer bone peptide attenuates ovariectomy-induced osteoporosis in mice via PPAR-γ/Axin2/Wnt signaling pathway

Journal of Functional Foods
Sika deer bone peptides (DBP-1-3) were extracted and purified from fresh deer bones. In ovariectomized (OVX) osteoporotic mice, DBP-1-3 increased serum calcitonin (CT), estradiol (E2), and 1,25(OH)2D3 while reducing Ca2+ and bone gla protein (BGP). Micro-
Guangchen Liu, Yue Ma, Guangxin Yuan, Hang Zhao, Ruofeng Yin   +4 more
doaj   +1 more source

Genetic Polymorphism of the Axin2 Gene in Wnt Pathway in Patients with Ovarian Cancer

Journal of Ardabil University of Medical Sciences, 2015
Background & objectives : Ovarian cancer is the most common female reproductive cancer which is caused due to the malignant transformation of ovarian cells.
B Davoodi, Kh Onsory, M Heydari Nasrabadi   +2 more
doaj