Results 51 to 60 of about 12,985 (151)

Analysis of AXIN2 gene mutations in a family with isolated oligodontia

口腔疾病防治, 2016
Objective To investigate the mutational characteristics of AXIN2 gene in a family affected by non⁃syn⁃ dromic oligodontia and to provide a molecular basis for studying the pathogenesis of oligodontia.
QIN Han, XU Hong⁃zhi, GONG Yong⁃ qing   +2 more
doaj   +1 more source

Axis inhibition protein 2 (AXIN2) polymorphisms and tooth agenesis [PDF]

Archives of Oral Biology, 2009
Tooth agenesis is a common congenital disorder that affects almost 20% of the world's population. A number of different genes have been shown to be associated with cases of tooth agenesis including AXIN2, IRF6, FGFR1, MSX1, PAX9, and TGFA. Of particular interest is AXIN2, which was linked to two families segregating oligodontia and colorectal cancer ...
N, Callahan, A, Modesto, R, Meira, F, Seymen, A, Patir, A R, Vieira   +5 more
openaire   +2 more sources

Formation of Tankyrase Inhibitor-Induced Degradasomes Requires Proteasome Activity.

PLoS ONE, 2016
In canonical Wnt signaling, the protein levels of the key signaling mediator β-catenin are under tight regulation by the multimeric destruction complex that mediates proteasomal degradation of β-catenin. In colorectal cancer, destruction complex activity
Nina Marie Pedersen, Tor Espen Thorvaldsen, Sebastian Wolfgang Schultz, Eva Maria Wenzel, Harald Stenmark   +4 more
doaj   +1 more source

Strong association between lung cancer and the AXIN2 polymorphism

Molecular Medicine Reports, 2009
Accumulated evidence suggests that alterations due to mutations or genetic polymorphisms in the AXIN2 tumor suppressor gene, a component of the Wnt signaling pathway, contributes to carcinogenesis. The effect of the AXIN2 exon 1 148 C↷T polymorphism was recently investigated in a Japanese population, but has not been investigated in other populations ...
Gunes, Emine Gulsen, Pinarbasi, Ergun, Pinarbasi, Hatice, Silig, Yavuz   +3 more
openaire   +4 more sources

AXIN2-associated autosomal dominant ectodermal dysplasia and neoplastic syndrome [PDF]

American Journal of Medical Genetics Part A, 2011
We describe a family with a novel, inherited AXIN2 mutation (c.1989G>A) segregating in an autosomal dominant pattern with oligodontia and variable other findings including colonic polyposis, gastric polyps, a mild ectodermal dysplasia phenotype with sparse hair and eyebrows, and early onset colorectal and breast cancers.
Marvin, Monica L., Mazzoni, Serina M., Herron, Casey M., Edwards, Sean, Gruber, Stephen B., Petty, Elizabeth M.   +5 more
openaire   +3 more sources

Regulation of epithelial branching morphogenesis and cancer cell growth of the prostate by Wnt signaling. [PDF]

PLoS ONE, 2008
Although Wnt signaling has been shown to be important for embryonic morphogenesis and cancer pathogenesis of several tissues, its role in prostatic development and tumorigenesis is not well understood.
Bu-Er Wang, Xi-De Wang, James A Ernst, Paul Polakis, Wei-Qiang Gao   +4 more
doaj   +1 more source

Mouse Axin and Axin2/Conductin Proteins Are Functionally Equivalent In Vivo [PDF]

Molecular and Cellular Biology, 2005
Axin is a central component of the canonical Wnt signal transduction machinery, serving as a scaffold for the beta-catenin destruction complex. The related protein Axin2/Conductin, although less extensively studied, is thought to perform similar functions.
Ian V, Chia, Frank, Costantini
openaire   +2 more sources

Dickkopf1--a new player in modelling the Wnt pathway.

PLoS ONE, 2011
The Wnt signaling pathway transducing the stabilization of β-catenin is essential for metazoan embryo development and is misregulated in many diseases such as cancers.
Lykke Pedersen, Mogens Høgh Jensen, Sandeep Krishna   +2 more
doaj   +1 more source

Association of AXIN2 gene polymorphisms with nonsyndromic oligodontia in Turkish families

Dentistry 3000, 2016
Tooth agenesis is the most common developmental abnormality of the human dentition characterized by the congenital absence of one or more permanent teeth.
Nuriye Dinckan, Zehra Oya Uyguner, Hulya Kayserili, Ariadne Letra   +3 more
doaj   +1 more source

Nkd1 functions downstream of Axin2 to attenuate Wnt signaling

Molecular Biology of the Cell
Wnt signaling is a crucial developmental pathway involved in early development as well as stem-cell maintenance in adults and its misregulation leads to numerous diseases. Thus, understanding the regulation of this pathway becomes vitally important. Axin2 and Nkd1 are widely utilized negative feedback regulators in Wnt signaling where Axin2 functions ...
Bell, Ian, Khan, Haider, Stutt, Nathan, Horn, Matthew, Hydzik, Teesha, Lum, Whitney, Rea, Victoria, Clapham, Emma, Hoeg, Lisa, Van Raay, Terence J.   +9 more
openaire   +2 more sources