Results 41 to 50 of about 12,985 (151)

Multi-omics analysis revealed TEK and AXIN2 are potential biomarkers in multifocal papillary thyroid cancer

Cancer Cell International, 2022
Background Papillary thyroid carcinoma (PTC), the most common endocrine cancer, accounts for 80–85% of all malignant thyroid tumors. This study focused on identifying targets that affect the multifocality of PTC.
Ga Hyun Kim, Hye Jin Heo, Ji Wan Kang, Eun-Kyung Kim, Seung Eun Baek, Keunyoung Kim, In Joo Kim, Sunghwan Suh, Byung-Joo Lee, Yun Hak Kim, Kyoungjune Pak   +10 more
doaj   +1 more source

Axin2-expressing cells execute regeneration after skeletal injury [PDF]

Scientific Reports, 2016
AbstractThe mammalian skeleton performs a diverse range of vital functions, requiring mechanisms of regeneration that restore functional skeletal cell populations after injury. We hypothesized that the Wnt pathway specifies distinct functional subsets of skeletal cell types, and that lineage tracing of Wnt-responding cells (WRCs) using the Axin2 gene ...
R. C. Ransom, D. J. Hunter, S. Hyman, G. Singh, S. C. Ransom, E. Z. Shen, K. C. Perez, M. Gillette, J. Li, B. Liu, J. B. Brunski, J. A. Helms   +11 more
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Analysis of Axin2 expression and function in murine models for pancreatic cancer [PDF]

Cell & Bioscience, 2016
The involvement of Wnt in carcinogenesis and progression of pancreatic cancer is currently intensely discussed. We evaluated activation of the Wnt signaling pathway by using a Wnt reporter mouse strain expressing β-galactosidase under the control of the Axin2 promotor during pancreatitis induced formation of precancerous lesions.
Dietmar Zechner, Tim Kroemer, Ann-Christin Albert, Maria Schönrogge, Tobias Radecke, Brigitte Vollmar   +5 more
openaire   +2 more sources

Axin2 coupled excessive Wnt‐glycolysis signaling mediates social defect in autism spectrum disorders

EMBO Molecular Medicine, 2023
Social dysfunction is the core syndrome of autism spectrum disorder (ASD) and lacks effective medicine. Although numerous risk genes and relevant environmental factors have been identified, the convergent molecular mechanism underlying ASD‐associated ...
Mengmeng Wang, Panpan Xian, Weian Zheng, Zhenzhen Li, Andi Chen, Haoxiang Xiao, Chao Xu, Fei Wang, Honghui Mao, Han Meng, Youyi Zhao, Ceng Luo, Yazhou Wang, Shengxi Wu   +13 more
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An Axin2 mutation and perinatal risk factors contribute to sagittal craniosynostosis: evidence from a Chinese female monochorionic diamniotic twin family

Hereditas, 2021
Background Craniosynostosis, defined as premature fusion of one or more cranial sutures, affects approximately 1 in every 2000–2500 live births. Sagittal craniosynostosis (CS), the most prevalent form of isolated craniosynostosis, is caused by interplay ...
Jin Xu, Qing Yan, Chengcheng Song, Jingjia Liang, Liang Zhao, Xin Zhang, Zhenkun Weng, Cheng Xu, Qian Liu, Shuqin Xu, Lu Pang, Liye Zhang, Yuan Sun, Gang Wang, Aihua Gu   +14 more
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Exploring the dynamics of adult Axin2 cell lineage integration into dentate gyrus granule neurons

Frontiers in Neuroscience
The Wnt pathway plays critical roles in neurogenesis. The expression of Axin2 is induced by Wnt/β-catenin signaling, making this gene a reliable indicator of canonical Wnt activity.
Khadijeh A. Sharifi, Khadijeh A. Sharifi, Faraz Farzad, Sauson Soldozy, Sauson Soldozy, Matthew R. DeWitt, Richard J. Price, Jason Sheehan, M. Yashar S. Kalani, M. Yashar S. Kalani, M. Yashar S. Kalani, Petr Tvrdik, Petr Tvrdik   +12 more
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Augmenting endogenous Wnt signaling improves skin wound healing. [PDF]

PLoS ONE, 2013
Wnt signaling is required for both the development and homeostasis of the skin, yet its contribution to skin wound repair remains controversial. By employing Axin2(LacZ/+) reporter mice we evaluated the spatial and temporal distribution patterns of Wnt ...
Jemima L Whyte, Andrew A Smith, Bo Liu, Wilfred R Manzano, Nick D Evans, Girija R Dhamdhere, Mark Y Fang, Howard Y Chang, Anthony E Oro, Jill A Helms   +9 more
doaj   +1 more source

AXIN2 polymorphism and its association with astrocytoma in a Turkish population

Molecular Medicine Reports, 2010
The product of AXIN2, a component of Wnt signalling, plays a role in tumorigenesis and is dysregulated in cancer cells. In order to determine whether the AXIN2 polymorphism is a risk factor for astrocytoma, we analysed eight polymorphic regions of this gene in 100 astrocytoma patients compared to 100 healthy controls in a Turkish population using PCR ...
Gunes, Emine Gulsen, Pinarbasi, Ergun, Pinarbasi, Hatice   +2 more
openaire   +4 more sources

Axin2 as regulatory and therapeutic target in newborn brain injury and remyelination [PDF]

Nature Neuroscience, 2011
Permanent damage to white matter tracts, comprising axons and myelinating oligodendrocytes, is an important component of brain injuries of the newborn that cause cerebral palsy and cognitive disabilities, as well as multiple sclerosis in adults. However, regulatory factors relevant in human developmental myelin disorders and in myelin regeneration are ...
Fancy, Stephen PJ, Harrington, Emily P, Yuen, Tracy J, Silbereis, John C, Zhao, Chao, Baranzini, Sergio E, Bruce, Charlotte C, Otero, Jose J, Huang, Eric J, Nusse, Roel, Franklin, Robin JM, Rowitch, David H   +11 more
openaire   +4 more sources

A latent Axin2 +/Scx + progenitor pool is the central organizer of tendon healing

npj Regenerative Medicine
A tendon’s ordered extracellular matrix (ECM) is essential for transmitting force but is also highly prone to injury. How tendon cells embedded within and surrounding this dense ECM orchestrate healing is not well understood.
Mor Grinstein, Stephanie L. Tsai, Daniel Montoro, Benjamin R. Freedman, Heather L. Dingwall, Steffany Villaseñor, Ken Zou, Moshe Sade-Feldman, Miho J. Tanaka, David J. Mooney, Terence D. Capellini, Jayaraj Rajagopal, Jenna L. Galloway   +12 more
doaj   +1 more source