Absence of endochondral ossification and craniosynostosis in posterior frontal cranial sutures of Axin2(-/-) mice. [PDF]
PLoS ONE, 2013 During the first month of life, the murine posterior-frontal suture (PF) of the cranial vault closes through endochondral ossification, while other sutures remain patent. These processes are tightly regulated by canonical Wnt signaling.
Björn Behr +2 more
doaj +1 more source
AXIN1 and AXIN2 variants in gastrointestinal cancers
Cancer Letters, 2014 Mutations in the APC (adenomatous polyposis coli) gene, which encodes a multi-functional protein with a well-defined role in the canonical Wnt pathway, underlie familial adenomatous polypsosis, a rare, inherited form of colorectal cancer (CRC) and contribute to the majority of sporadic CRCs.
Mazzoni, Serina M., Fearon, Eric R.
openaire +2 more sources
Enhanced Activation of Canonical Wnt Signaling Confers Mesoderm-Derived Parietal Bone with Similar Osteogenic and Skeletal Healing Capacity to Neural Crest-Derived Frontal Bone. [PDF]
PLoS ONE, 2015 Bone formation and skeletal repair are dynamic processes involving a fine-tuned balance between osteoblast proliferation and differentiation orchestrated by multiple signaling pathways.
Shuli Li +5 more
doaj +1 more source
Axin2 regulates chondrocyte maturation and axial skeletal development [PDF]
Journal of Orthopaedic Research, 2009 AbstractAxis inhibition proteins 1 and 2 (Axin1 and Axin2) are scaffolding proteins that modulate at least two signaling pathways that are crucial in skeletogenesis: the Wnt/β‐catenin and TGF‐β signaling pathways. To determine whether Axin2 is important in skeletogenesis, we examined the skeletal phenotype of Axin2‐null mice in a wild‐type or Axin1 ...
Debbie Y, Dao +5 more
openaire +2 more sources
Variations in AXIN2 predict risk and prognosis of colorectal cancer [PDF]
BDJ Open, 2019 Abstract Objective Colorectal cancer (CRC) and hypodontia are frequent and different diseases with common genes are involved in their etiology. The objective of this study was to identify the association between AXIN2 rs2240308 with hypodontia and CRC.
Liliana Otero +5 more
openaire +6 more sources
Tumor Biology, 2017 Wnt pathway has been implicated in the process of human carcinogenesis. Axis inhibition protein2 ( Axin2 ), a major scaffold protein is an antagonist of Wnt pathway and is potent to act as a tumor suppressor gene in various human cancers.
Charu Bahl +3 more
doaj +1 more source
Axin1 prevents Salmonella invasiveness and inflammatory response in intestinal epithelial cells. [PDF]
PLoS ONE, 2012 Axin1 and its homolog Axin2 are scaffold proteins essential for regulating Wnt signaling. Axin-dependent regulation of Wnt is important for various developmental processes and human diseases.
Yong-guo Zhang +7 more
doaj +1 more source
Epigenetic silencing of AXIN2 in colorectal carcinoma with microsatellite instability [PDF]
Oncogene, 2005 Mutation or epigenetic silencing of mismatch repair genes, such as MLH1 and MSH2, results in microsatellite instability (MSI) in the genome of a subset of colorectal carcinomas (CRCs). However, little is yet known of genes that directly contribute to tumor formation in such cancers.
K, Koinuma +12 more
openaire +2 more sources
Cancer Cell International, 2019 Background Many epidemiological studies have investigated association of AXIN2 variants on overall cancer risks; however, the available results remain inconsistent.
Bin Xu +6 more
doaj +1 more source
Differential Roles of AXIN1 and AXIN2 in Tankyrase Inhibitor-Induced Formation of Degradasomes and β-Catenin Degradation. [PDF]
PLoS ONE, 2017 Inhibition of the tankyrase enzymes (TNKS1 and TNKS2) has recently been shown to induce highly dynamic assemblies of β-catenin destruction complex components known as degradasomes, which promote degradation of β-catenin and reduced Wnt signaling activity
Tor Espen Thorvaldsen +3 more
doaj +1 more source