Results 11 to 20 of about 12,985 (151)
Neoplasia: An International Journal for Oncology Research, 2015 Heterozygous, germline nonsense mutations in AXIN2 have been reported in two families with oligodontia and colorectal cancer (CRC) predisposition, including an AXIN2 1989G>A mutation. Somatic AXIN2 mutations predicted to generate truncated AXIN2 (trAXIN2)
Serina M. Mazzoni +3 more
doaj +3 more sources
Axin2/Conductin Is Required for Normal Haematopoiesis and T Lymphopoiesis
Cells, 2022 The development of T lymphocytes in the thymus and their stem cell precursors in the bone marrow is controlled by Wnt signaling in strictly regulated, cell-type specific dosages.
Jolanda J. D. de Roo +8 more
doaj +5 more sources
A novel pathogenic frameshift variant in AXIN2 in a man with polyposis and hypodontia
Hereditary Cancer in Clinical Practice, 2023 Background WNT signaling is pivotal in embryogenesis and tissue homeostasis. Aberrant WNT signaling, due to mutations in components of this pathway, contributes to the development and progression of human cancers, including colorectal cancer.
M. F. Broekema +3 more
doaj +5 more sources
Expression Pattern of Axin2 During Chicken Development. [PDF]
PLoS ONE, 2016 Canonical Wnt-signalling is well understood and has been extensively described in many developmental processes. The regulation of this signalling pathway is of outstanding relevance for proper development of the vertebrate and invertebrate embryo.
Gesa Eckei +3 more
doaj +4 more sources
A Novel AXIN2 Missense Mutation Is Associated with Non-Syndromic Oligodontia. [PDF]
PLoS ONE, 2015 Oligodontia is defined as the congenital absence of six or more permanent teeth, excluding the third molars. Oligodontia may contribute to masticatory dysfunction, speech alteration, aesthetic problems and malocclusion.
Haochen Liu +3 more
doaj +4 more sources
AXIN2-Associated Adenomatous Colorectal Polyposis [PDF]
Journal of Coloproctology, 2021 Abstract Introduction Most cases of colorectal cancer (CRC) occur sporadically; however, ∼ 3% to 6% of all CRCs are related to inherited syndromes, such as Lynch syndrome and familial adenomatous polyposis (FAP). The adenomatous polyposis coli (APC) and mutY DNA glycosylase (MUTYH) germline mutations are the main genetic causes related to ...
Bruno Augusto Alves Martins +3 more
openaire +5 more sources
AXIN2 is Associated With Papillary Thyroid Carcinoma [PDF]
Iranian Red Crescent Medical Journal, 2016 Findings of recent studies have demonstrated a rapid increase of the incidence of papillary thyroid carcinoma (PTC), which accounts for nearly 80% of thyroid cancers.The aim of this study was to explore the association between AXIN2 gene polymorphism and papillary thyroid carcinoma (PTC).106 blood samples (56 PTC patients and 50 healthy controls) were ...
Liu, Xin +6 more
openaire +2 more sources
The role of Axin2 in calvarial morphogenesis and craniosynostosis [PDF]
Development, 2005 Axin1 and its homolog Axin2/conductin/Axil are negative regulators of the canonical Wnt pathway that suppress signal transduction by promoting degradation of β-catenin. Mice with deletion of Axin1 exhibit defects in axis determination and brain patterning during early embryonic development.
Hsiao-Man Ivy, Yu +7 more
openaire +2 more sources
Prophylactic subtotal colectomy in a patient with an AXIN2 mutation [PDF]
Journal of Surgical Case Reports, 2021 Abstract A number of genetic syndromes that predispose patients to colon cancer have been well described, allowing for improved surveillance, diagnosis and treatment. However, other syndromes likely exist but have yet to be thoroughly characterized.
openaire +2 more sources
Frontiers in Oncology, 2022 ObjectivesThe concept of adequate surgical margins remains controversial in oral squamous cell carcinoma (OSCC) surgery. This study aimed to identify surgical margin-related indicators that might impact recurrence and survival of OSCC patients.Materials ...
Meiling Pei +12 more
doaj +1 more source